Q8T6H3 (ABCC6_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter C family member 6

Alternative name(s):
ABC transporter ABCC.6

Gene names

Name:	abcC6
ORF Names:	DDB_G0287593

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Coiled coil Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1351	1351	ABC transporter C family member 6		PRO_0000363851
Regions
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	149 – 169	21	Helical; Potential
	Transmembrane	248 – 268	21	Helical; Potential
	Transmembrane	771 – 791	21	Helical; Potential
	Transmembrane	815 – 835	21	Helical; Potential
	Transmembrane	904 – 924	21	Helical; Potential
	Transmembrane	977 – 999	23	Helical; Potential
	Transmembrane	1002 – 1022	21	Helical; Potential
	Transmembrane	1025 – 1045	21	Helical; Potential
	Domain	112 – 397	286	ABC transmembrane type-1 1
	Domain	474 – 700	227	ABC transporter 1
	Domain	777 – 1060	284	ABC transmembrane type-1 2
	Domain	1101 – 1336	236	ABC transporter 2
	Nucleotide binding	510 – 517	8	ATP Potential
	Nucleotide binding	1135 – 1142	8	ATP Potential
	Coiled coil	701 – 734	34	Potential
	Compositional bias	470 – 473	4	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q8T6H3 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: FB3E88A0D05BA25A	FASTA	1,351	154,308
	10 20 30 40 50 60 MFTKILKKFF SSYEKLKDNE DENEPSSNST NNFYKTCPED NSSKWSKISF NWVTKLIMKG 70 80 90 100 110 120 YLKESLEMND IYDLPELNKV QTTSKLLEDI DLSNNSNYTL IKHIYKKFLP KNKYALVSNL 130 140 150 160 170 180 FIIIFTFLSP ICLKFLINYI SIQDENEKSI LKGILLCCLL CLCVLGQSIS QELFYWFGIK 190 200 210 220 230 240 NGFDVRGALA AKIFEKTLKL SNASRKEYKS GKIMNIMSID VANISEYFWT HHINIVSHFI 250 260 270 280 290 300 QILSLVGLLC YVVGPSGLVG FGVMVIALPI NAMLCAKSSN YLEKSLEYSD SRTNLTSELI 310 320 330 340 350 360 TNIRPFKMYA WENFFINKID GQRKQELKNI FLRIFYSILD HMMIETNATL VLVSTFATYS 370 380 390 400 410 420 LNGNTMSLDV TFTAMTIFSK LEVPLIRLPY DIFKAIGLIP SVKRVQNFLK SSESLKYNKN 430 440 450 460 470 480 FKNENQKITT TKENNNQHGQ DNDIIVENCT FQWNEPENNN IFELNYGDNE EEENQDESIN 490 500 510 520 530 540 KKENDNEEFN YKLKDINLIV PKGKLTMICG VVGSGKTSLI FGLIGEIYKL NGSVSGVPNN 550 560 570 580 590 600 ISFTSQQPFL LSASLRENIL FGNEFDIERY KKVIESTALT KDIVNLAGLD LTEIGERGIN 610 620 630 640 650 660 LSGGQKQRIS LARALYANSD CFIFDEPLSA VDPEVASHLF DHCIQGELMR NKTRILVTHQ 670 680 690 700 710 720 LQFIPYADHI IVLNSNGQLI QGTYQELNEK GIDFKSILKT KEIKKNVENE TDSEELIKNE 730 740 750 760 770 780 IEIENEIIDV NNAISDKNDP NLIEKAKLLV KEDKNEGEVE FNVYKKYFSY GSSGVTLFIT 790 800 810 820 830 840 ISLFFVGQAI FKVSDFWLTI WTERSIEGKS DSFYIGYYLL IFGTFVVILM IRILLLCRIT 850 860 870 880 890 900 FNVGKNLHSA LLKSVTYASC RFFDTNPSGR ILNRFSKDTS DIDIHMFDIL TEVSMCFSEL 910 920 930 940 950 960 TIGLISIVFI IPIMVIPLII LSIAYYILQR LYRPSARELN RWESITVSPI FSLLQECYNG 970 980 990 1000 1010 1020 LLTIRTYKQE SRFIKEMFDN ININLGCFFY SFAVHRWVSM RLEVMGWIMV FFTSLIATLF 1030 1040 1050 1060 1070 1080 ISNNGLAALS VTTALSLNGY LSWGIRRIVD LEVKMNSFQR IQSYIEIPKE GNKLVSTNSN 1090 1100 1110 1120 1130 1140 EVDNHTIKDA DLVNWPNKGI IEFKNVEIKY RPNSEPNLKD LSFKVQSSEK IGIVGRTGAG 1150 1160 1170 1180 1190 1200 KTTIASSLFR MVECSKGLIL IDGIDISKVQ LQKLRSSIGI VPQDPFIFTG TIRSNIDPFN 1210 1220 1230 1240 1250 1260 EFTDFEIWES VEKVKLKDAI NSMPLKLETA LQENGDNGFS YGQKQLLCLC RTILKNFKII 1270 1280 1290 1300 1310 1320 LMDEATSSID YHTAQLIKQT IQENFKDCTT LTIAHRLETI IDCNKIAVID SGQLIEFDTP 1330 1340 1350 SNLMNIPNSK FNKLIKSQTD YNNNEKTIIN K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF474338 Genomic DNA. Translation: AAL85709.1. AAFI02000103 Genomic DNA. Translation: EAL63605.1.
RefSeq	XP_637141.1. XM_632049.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ProteinModelPortal	Q8T6H3.
ModBase	Search...
Proteomic databases
PRIDE	Q8T6H3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0219975; DDB0219975; DDB_G0287593.
GeneID	8626236.
GenomeReviews	Gene locus abcC6 in contig CM000154_GR.
KEGG	ddi:DDB_G0287593.
Organism-specific databases
dictyBase	DDB_G0287593. abcC6.
Phylogenomic databases
eggNOG	KOG0054.
GeneTree	EPrGT00050000000398.
HOGENOM	HBG758042.
InParanoid	Q8T6H3.
OMA	RENANIF.
PhylomeDB	Q8T6H3.
ProtClustDB	CLSZ2430599.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCC6_DICDI

Accession

Primary (citable) accession number: Q8T6H3
Secondary accession number(s): Q54K23

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	September 21, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)