Q8T6B3 (MT1_TETTH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Metallothionein-1 Short name=MT-1
Organism	Tetrahymena thermophila
Taxonomic identifier	5911 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Hymenostomatida › Tetrahymenina › Tetrahymenidae › Tetrahymena

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The metallothioneins are involved in the cellular sequestration of toxic metal ions. Binds 12 cadmium ions per molecule By similarity.
Sequence similarities	Belongs to the metallothionein superfamily. Type 7 family.

Ontologies

Keywords
Ligand	Cadmium Metal-binding Metal-thiolate cluster
Gene Ontology (GO)
Molecular_function	cadmium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Metallothionein-1		PRO_0000197360

Sequences

	Sequence		Length	Mass (Da)
	Q8T6B3 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 05C848DF1A8E4647	FASTA	107	11,179
	10 20 30 40 50 60 MDKVNNNCCC GENAKPCCTD PNSGCCCVSE TNNCCKSDKK ECCTGTGEGC KWTGCKCCQP 70 80 90 100 AKSGCCCGDK AKACCTDPNS GCCCSSKTNK CCDSTNKTEC KTCECCK

References

[1]	Piccinni E., Boldrin F., Santovito G., Irato P. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF479587 Genomic DNA. Translation: AAL87688.1.
3D structure databases
ProteinModelPortal	Q8T6B3.
ModBase	Search...
Protein-protein interaction databases
STRING	5911.Q8T6B3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG85154.
Family and domain databases
InterPro	IPR012484. Metalthion_7. [Graphical view]
Pfam	PF07846. Metallothio_7. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MT1_TETTH

Accession

Primary (citable) accession number: Q8T6B3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	June 1, 2002
Last modified:	April 3, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)