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Protein

Glyceraldehyde-3-phosphate dehydrogenase

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei35NADCombined sources1
Binding sitei80NADCombined sources1
Binding sitei122NADCombined sources1
Active sitei153NucleophileUniRule annotation1
Sitei180Activates thiol group during catalysisUniRule annotation1
Binding sitei183Glyceraldehyde 3-phosphateUniRule annotation1
Binding sitei237Glyceraldehyde 3-phosphateUniRule annotation1
Binding sitei319NADCombined sources1
Binding sitei323NADCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADCombined sources4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processGlycolysisUniRule annotation
LigandNADUniRule annotationCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

UniPathwayiUPA00109; UER00184

Names & Taxonomyi

Protein namesi
Recommended name:
Glyceraldehyde-3-phosphate dehydrogenaseUniRule annotation (EC:1.2.1.12UniRule annotation)
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3559677

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YWGX-ray2.60O/P/Q/R1-337[»]
2B4RX-ray2.25O/P/Q/R1-337[»]
2B4TX-ray2.50O/P/Q/R1-337[»]
ProteinModelPortaliQ8T6B1
SMRiQ8T6B1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8T6B1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 153Gp_dh_NInterPro annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 154Glyceraldehyde 3-phosphate bindingUniRule annotation3
Regioni214 – 215Glyceraldehyde 3-phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0657 Eukaryota
COG0057 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR020831 GlycerAld/Erythrose_P_DH
IPR020830 GlycerAld_3-P_DH_AS
IPR020829 GlycerAld_3-P_DH_cat
IPR020828 GlycerAld_3-P_DH_NAD(P)-bd
IPR006424 Glyceraldehyde-3-P_DH_1
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR10836 PTHR10836, 1 hit
PfamiView protein in Pfam
PF02800 Gp_dh_C, 1 hit
PF00044 Gp_dh_N, 1 hit
PIRSFiPIRSF000149 GAP_DH, 1 hit
PRINTSiPR00078 G3PDHDRGNASE
SMARTiView protein in SMART
SM00846 Gp_dh_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01534 GAPDH-I, 1 hit
PROSITEiView protein in PROSITE
PS00071 GAPDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8T6B1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKLGING FGRIGRLVFR AAFGRKDIEV VAINDPFMDL NHLCYLLKYD
60 70 80 90 100
SVHGQFPCEV THADGFLLIG EKKVSVFAEK DPSQIPWGKC QVDVVCESTG
110 120 130 140 150
VFLTKELASS HLKGGAKKVI MSAPPKDDTP IYVMGINHHQ YDTKQLIVSN
160 170 180 190 200
ASCTTNCLAP LAKVINDRFG IVEGLMTTVH ASTANQLVVD GPSKGGKDWR
210 220 230 240 250
AGRCALSNII PASTGAAKAV GKVLPELNGK LTGVAFRVPI GTVSVVDLVC
260 270 280 290 300
RLQKPAKYEE VALEIKKAAE GPLKGILGYT EDEVVSQDFV HDNRSSIFDM
310 320 330
KAGLALNDNF FKLVSWYDNE WGYSNRVLDL AVHITNN
Length:337
Mass (Da):36,635
Last modified:June 1, 2002 - v1
Checksum:iC678D13F328F2BA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF479765 mRNA Translation: AAL87686.1

Similar proteinsi

Entry informationi

Entry nameiQ8T6B1_PLAFA
AccessioniPrimary (citable) accession number: Q8T6B1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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