Glyceraldehyde-3-phosphate dehydrogenase

Preferred order of sections

Names and origin

Protein names	Submitted name: Glyceraldehyde-3-phosphate dehydrogenase EMBL AAL87686.1
Organism	Plasmodium falciparum EMBL AAL87686.1
Taxonomic identifier	5833 [NCBI]
Taxonomic lineage	Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. RuleBase RU000397

Ontologies

Keywords
Ligand	NAD PDB 1YWG PDB 2B4R PDB 2B4T Nucleotide-binding PDB 1YWG PDB 2B4R PDB 2B4T
Molecular function	Oxidoreductase RuleBase RU004274
Technical term	3D-structure PDB 1YWG PDB 2B4R PDB 2B4T
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Regions

Nucleotide binding

11 – 14

4

NAD PDB 1YWG PDB 2B4R PDB 2B4T

Sites

Binding site

35

1

NAD PDB 1YWG PDB 2B4R PDB 2B4T

Binding site

80

1

NAD PDB 1YWG PDB 2B4R PDB 2B4T

Binding site

122

1

NAD PDB 1YWG PDB 2B4R PDB 2B4T

Binding site

319

1

NAD PDB 1YWG PDB 2B4R PDB 2B4T

Binding site

323

1

NAD PDB 1YWG PDB 2B4R PDB 2B4T

Sequences

Sequence

Length

Mass (Da)

Tools

Q8T6B1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C678D13F328F2BA9
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FASTA

337

36,635

        10         20         30         40         50         60 
MAVTKLGING FGRIGRLVFR AAFGRKDIEV VAINDPFMDL NHLCYLLKYD SVHGQFPCEV 

        70         80         90        100        110        120 
THADGFLLIG EKKVSVFAEK DPSQIPWGKC QVDVVCESTG VFLTKELASS HLKGGAKKVI 

       130        140        150        160        170        180 
MSAPPKDDTP IYVMGINHHQ YDTKQLIVSN ASCTTNCLAP LAKVINDRFG IVEGLMTTVH 

       190        200        210        220        230        240 
ASTANQLVVD GPSKGGKDWR AGRCALSNII PASTGAAKAV GKVLPELNGK LTGVAFRVPI 

       250        260        270        280        290        300 
GTVSVVDLVC RLQKPAKYEE VALEIKKAAE GPLKGILGYT EDEVVSQDFV HDNRSSIFDM 

       310        320        330 
KAGLALNDNF FKLVSWYDNE WGYSNRVLDL AVHITNN

« Hide

References

[1]	Li G.-D., Ward S.A. Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum." Satchell J.F., Malby R.L., Luo C.S., Adisa A., Alpyurek A.E., Klonis N., Smith B.J., Tilley L., Colman P.M. Acta Crystallogr. D Biol. Crystallogr. 61:1213-1221(2005) [PubMed: 16131754] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH NAD.
[3]	"Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site." Robien M.A., Bosch J., Buckner F.S., Van Voorhis W.C., Worthey E.A., Myler P., Mehlin C., Boni E.E., Kalyuzhniy O., Anderson L., Lauricella A., Gulde S., Luft J.R., DeTitta G., Caruthers J.M., Hodgson K.O., Soltis M., Zucker F. Hol W.G. Proteins 62:570-577(2006) [PubMed: 16345073] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 1-335 IN COMPLEX WITH NAD.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF479765 mRNA. Translation: AAL87686.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YWG	X-ray	2.60	O/P/Q/R	1-337	[»]
2B4R	X-ray	2.25	O/P/Q/R	1-335	[»]
2B4T	X-ray	2.50	O/P/Q/R	1-335	[»]

ProteinModelPortal

Q8T6B1.

SMR

Q8T6B1. Positions 1-337.

ModBase

Search...

Protein-protein interaction databases

STRING

Q8T6B1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblProtists

PF14_0598:mRNA; PF14_0598:pep; PF14_0598.

Phylogenomic databases

PhylomeDB

Q8T6B1.

Family and domain databases

InterPro

IPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

PANTHER

PTHR10836. GAP_DH. 1 hit.

Pfam

PF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]

PIRSF

PIRSF000149. GAP_DH. 1 hit.

PRINTS

PR00078. G3PDHDRGNASE.

SMART

SM00846. Gp_dh_N. 1 hit.
[Graphical view]

TIGRFAMs

TIGR01534. GAPDH-I. 1 hit.

PROSITE

PS00071. GAPDH. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8T6B1_PLAFA

Accession

Primary (citable) accession number: Q8T6B1

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)