Reviewed, UniProtKB/Swiss-Prot Q8T5Z7 (ABCA1_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter A family member 1
Alternative name(s):
    ABC transporter ABCA.1

Gene names

Name:	abcA1
Synonyms:	abcA
ORF Names:	DDB_G0291994

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	877 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 877	877	ABC transporter A family member 1		PRO_0000363833
Regions
	Transmembrane	46 – 66	21	Potential
	Transmembrane	268 – 288	21	Potential
	Transmembrane	324 – 344	21	Potential
	Transmembrane	347 – 367	21	Potential
	Transmembrane	379 – 399	21	Potential
	Transmembrane	420 – 440	21	Potential
	Transmembrane	479 – 499	21	Potential
	Domain	552 – 788	237	ABC transporter
	Nucleotide binding	591 – 598	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8T5Z7-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: DBEC7C7ECCB343D9	FASTA	877	97,375
	10 20 30 40 50 60 MSTYSRYNDE DEIRNNKISF GDNIKREFLH LKLLLKKNLL VSIRSYFSTG IEILSPIAFI 70 80 90 100 110 120 IILFLISHFG SGNENPIVTY NQELPICKSY GENRCFNIMF SPSNSPSAIA IMEMLGEINN 130 140 150 160 170 180 NSIYSYPSDT GYLPDLNNTI GLKGGLIMMN SIEDSFEFVL AHPNVTIAAV DFLSIPLGFQ 190 200 210 220 230 240 INGAPPKNEP LLKMDGNSLE FNVVVNTTCP NILATCPDYS IAITTAIEKA VITYYSQKIR 250 260 270 280 290 300 NEKIPPPTIS YGSNAFPRYP PEQGAARVWG GLFYYCGSMI SFIFLLYKVS FEKENKLKQG 310 320 330 340 350 360 MVMMGLSVNQ YWISWFITSF TIDILISLIT IIVGLACQLP FFLGSNFFVL IITFSLFTIS 370 380 390 400 410 420 MSSVAFFLLT FIQSTKSAIG IGMGIFIVGS IFQLVFSGMG TMIFELIYQT NSNGALAARI 430 440 450 460 470 480 ILFFIPMFHF TKVLTDIGNV TTNYPLLTYK FSDLSTDLNI GGTVLKTVIP TTGQSICYLL 490 500 510 520 530 540 ALIGVYTVLA WYFEHIIPGN DGTSSPPWFF VLPSYWGLSL KKVRHIPTPY FDDEDVRAAI 550 560 570 580 590 600 TKAHDASNRA PLIICGLSKS YTKLFRPKKT VHAVKYLSLS VEKGTILGFL GSNGCGKSTT 610 620 630 640 650 660 IGMLTGLLEP TAGDALVYGH SVISNIAAVR RITSVVPQHD ILWAEMTARE HLQLFSELKG 670 680 690 700 710 720 IPAQERESQI QKVLDQVRLS KISNNLISTY SGGMKRRLSV AIACIGDPKI IFMDEPTTGV 730 740 750 760 770 780 DPSSKRHLID LVKSIKNDKV IILTSHDMHE VEILADKIVI MNEGVMACNG NSLQLKSKYG 790 800 810 820 830 840 EGYSVNIVAK SPESIPAVVE FVTLSIPGCK FMKQSALQLN FGFPVTIDHQ IIANFFKQLE 850 860 870 EITNDPNNQL MRDWSVSHST LDDVFLKVSH LAKLKTQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	Loomis W.F. Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 174-828. Strain: AX4.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF491005 Genomic DNA. Translation: AAL99041.1. AAFI02000187 Genomic DNA. Translation: EAL61353.1. U66526 mRNA. Translation: AAB06789.2.
PIR	T18288.
RefSeq	XP_629792.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3386469.
GenomeReviews	Gene locus abcA1 in contig CM000155_GR.
KEGG	ddi:DDB_0191222.
Organism-specific databases
dictyBase	DDB_G0291994. abcA1.
Phylogenomic databases
HOGENOM	HBG082641.
InParanoid	Q8T5Z7.
OMA	RINNTIT.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA1_DICDI

Accession

Primary (citable) accession number: Q8T5Z7
Secondary accession number(s): Q54DT0, Q94479

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	December 15, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)