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Protein

Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Gene

beg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondrias (By similarity).By similarity

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158By similarity1
Active sitei275By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DME-77289. Mitochondrial Fatty Acid Beta-Oxidation.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Bad egg
[Acyl-carrier-protein] malonyltransferase
Gene namesi
Name:beg
ORF Names:CG7842
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036691. beg.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Eggs have a thin shell.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 23MitochondrionSequence analysisAdd BLAST23
ChainiPRO_000000059024 – 379Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrialAdd BLAST356

Proteomic databases

PaxDbiQ8T3L6.
PRIDEiQ8T3L6.

Expressioni

Gene expression databases

BgeeiFBgn0036691.
GenevisibleiQ8T3L6. DM.

Interactioni

Protein-protein interaction databases

IntActiQ8T3L6. 5 interactors.
STRINGi7227.FBpp0075038.

Structurei

3D structure databases

ProteinModelPortaliQ8T3L6.
SMRiQ8T3L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II malonyltransferase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2926. Eukaryota.
COG0331. LUCA.
GeneTreeiENSGT00390000013715.
InParanoidiQ8T3L6.
KOiK00645.
OMAiAANYNCP.
OrthoDBiEOG091G09QO.
PhylomeDBiQ8T3L6.

Family and domain databases

InterProiView protein in InterPro
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR020801. PKS_acyl_transferase.
PfamiView protein in Pfam
PF00698. Acyl_transf_1. 1 hit.
SMARTiView protein in SMART
SM00827. PKS_AT. 1 hit.
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T3L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAARRLLRS PRITGALSWS RWSSDAAKAT TETSALLQNA EKRQQLLNEL
60 70 80 90 100
SEPLEQKGRP AIDPKETSVM LFPGQGTQYV GMAKDLLRFP GARRIFELAN
110 120 130 140 150
EVLKYDLLKI CLEGPREKLN RTEHAQLAVM VSSLAALEQL REERPKAIET
160 170 180 190 200
CVAAAGFSLG EITALVYADA LPFDKALRLV QVRATAMQAA CDQAAGAMAM
210 220 230 240 250
TLYGPDTNLG EACARAQQWC LDKGVESPYC GIANYMYPHC KVVAGNVEAL
260 270 280 290 300
EFLEQNAKSF KIRRMKRLAV SGAFHTPLMQ SAVEPFTKAL KTVRLQDPVI
310 320 330 340 350
RVYSNVDGKP YRHAKHILTQ LPKQIVRPVK WEQTLHEMYE RKQGVDFPRT
360 370
FECGPGKGLV QVLEKVNAKA AQSSFNVIA
Length:379
Mass (Da):42,086
Last modified:June 7, 2004 - v2
Checksum:iDC9BCD8624C7B623
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61A → T in AAM11123 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49377.1.
AY094770 mRNA. Translation: AAM11123.1.
BT050494 mRNA. Translation: ACJ13201.1.
RefSeqiNP_648950.1. NM_140693.3.
UniGeneiDm.12916.

Genome annotation databases

EnsemblMetazoaiFBtr0075278; FBpp0075038; FBgn0036691.
GeneIDi39910.
KEGGidme:Dmel_CG7842.
UCSCiCG7842-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiFABD_DROME
AccessioniPrimary (citable) accession number: Q8T3L6
Secondary accession number(s): B6IDQ4, Q9VVD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: August 30, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families