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Q8T3L6

- FABD_DROME

UniProt

Q8T3L6 - FABD_DROME

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Protein
Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial
Gene
beg, CG7842
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondrias By similarity.

Catalytic activityi

Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581 By similarity
Active sitei275 – 2751 By similarity

GO - Molecular functioni

  1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB
  2. transferase activity Source: UniProtKB

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB
  2. metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
Short name:
MCT
Alternative name(s):
Bad egg
[Acyl-carrier-protein] malonyltransferase
Gene namesi
Name:beg
ORF Names:CG7842
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036691. beg.

Subcellular locationi

Mitochondrion Inferred

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Eggs have a thin shell.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323Mitochondrion Reviewed prediction
Add
BLAST
Chaini24 – 379356Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial
PRO_0000000590Add
BLAST

Proteomic databases

PaxDbiQ8T3L6.

Expressioni

Gene expression databases

BgeeiQ8T3L6.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0075038.

Structurei

3D structure databases

ProteinModelPortaliQ8T3L6.
SMRiQ8T3L6. Positions 16-373.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0331.
GeneTreeiENSGT00390000013715.
InParanoidiQ8T3L6.
KOiK00645.
OMAiAMTLYGP.
OrthoDBiEOG7D85X6.
PhylomeDBiQ8T3L6.

Family and domain databases

Gene3Di3.40.366.10. 2 hits.
InterProiIPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T3L6-1 [UniParc]FASTAAdd to Basket

« Hide

MLAARRLLRS PRITGALSWS RWSSDAAKAT TETSALLQNA EKRQQLLNEL    50
SEPLEQKGRP AIDPKETSVM LFPGQGTQYV GMAKDLLRFP GARRIFELAN 100
EVLKYDLLKI CLEGPREKLN RTEHAQLAVM VSSLAALEQL REERPKAIET 150
CVAAAGFSLG EITALVYADA LPFDKALRLV QVRATAMQAA CDQAAGAMAM 200
TLYGPDTNLG EACARAQQWC LDKGVESPYC GIANYMYPHC KVVAGNVEAL 250
EFLEQNAKSF KIRRMKRLAV SGAFHTPLMQ SAVEPFTKAL KTVRLQDPVI 300
RVYSNVDGKP YRHAKHILTQ LPKQIVRPVK WEQTLHEMYE RKQGVDFPRT 350
FECGPGKGLV QVLEKVNAKA AQSSFNVIA 379
Length:379
Mass (Da):42,086
Last modified:June 7, 2004 - v2
Checksum:iDC9BCD8624C7B623
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti61 – 611A → T in AAM11123. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF49377.1.
AY094770 mRNA. Translation: AAM11123.1.
BT050494 mRNA. Translation: ACJ13201.1.
RefSeqiNP_648950.1. NM_140693.3.
UniGeneiDm.12916.

Genome annotation databases

EnsemblMetazoaiFBtr0075278; FBpp0075038; FBgn0036691.
GeneIDi39910.
KEGGidme:Dmel_CG7842.
UCSCiCG7842-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF49377.1 .
AY094770 mRNA. Translation: AAM11123.1 .
BT050494 mRNA. Translation: ACJ13201.1 .
RefSeqi NP_648950.1. NM_140693.3.
UniGenei Dm.12916.

3D structure databases

ProteinModelPortali Q8T3L6.
SMRi Q8T3L6. Positions 16-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7227.FBpp0075038.

Proteomic databases

PaxDbi Q8T3L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0075278 ; FBpp0075038 ; FBgn0036691 .
GeneIDi 39910.
KEGGi dme:Dmel_CG7842.
UCSCi CG7842-RA. d. melanogaster.

Organism-specific databases

CTDi 39910.
FlyBasei FBgn0036691. beg.

Phylogenomic databases

eggNOGi COG0331.
GeneTreei ENSGT00390000013715.
InParanoidi Q8T3L6.
KOi K00645.
OMAi AMTLYGP.
OrthoDBi EOG7D85X6.
PhylomeDBi Q8T3L6.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Miscellaneous databases

GenomeRNAii 39910.
NextBioi 816051.
PROi Q8T3L6.

Gene expression databases

Bgeei Q8T3L6.

Family and domain databases

Gene3Di 3.40.366.10. 2 hits.
InterProi IPR001227. Ac_transferase_dom.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR016036. Malonyl_transacylase_ACP-bd.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 2 hits.
SSF55048. SSF55048. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Ovary.
  4. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
  5. "Conditional switches for extracellular matrix patterning in Drosophila melanogaster."
    Khokhar A., Chen N., Yuan J.-P., Li Y., Landis G.N., Beaulieu G., Kaur H., Tower J.
    Genetics 178:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiFABD_DROME
AccessioniPrimary (citable) accession number: Q8T3L6
Secondary accession number(s): B6IDQ4, Q9VVD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 3, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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