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Q8T3L6

- FABD_DROME

UniProt

Q8T3L6 - FABD_DROME

Protein

Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial

Gene

beg

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the ACP protein. This suggests the existence of the biosynthesis of fatty acids in mitochondrias By similarity.By similarity

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei158 – 1581By similarity
    Active sitei275 – 2751By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB
    2. transferase activity Source: UniProtKB

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB
    2. metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial (EC:2.3.1.39)
    Short name:
    MCT
    Alternative name(s):
    Bad egg
    [Acyl-carrier-protein] malonyltransferase
    Gene namesi
    Name:beg
    ORF Names:CG7842
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0036691. beg.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Disruption phenotypei

    Eggs have a thin shell.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2323MitochondrionSequence AnalysisAdd
    BLAST
    Chaini24 – 379356Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrialPRO_0000000590Add
    BLAST

    Proteomic databases

    PaxDbiQ8T3L6.

    Expressioni

    Gene expression databases

    BgeeiQ8T3L6.

    Interactioni

    Protein-protein interaction databases

    STRINGi7227.FBpp0075038.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8T3L6.
    SMRiQ8T3L6. Positions 16-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the type II malonyltransferase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0331.
    GeneTreeiENSGT00390000013715.
    InParanoidiQ8T3L6.
    KOiK00645.
    OMAiAMTLYGP.
    OrthoDBiEOG7D85X6.
    PhylomeDBiQ8T3L6.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8T3L6-1 [UniParc]FASTAAdd to Basket

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    MLAARRLLRS PRITGALSWS RWSSDAAKAT TETSALLQNA EKRQQLLNEL    50
    SEPLEQKGRP AIDPKETSVM LFPGQGTQYV GMAKDLLRFP GARRIFELAN 100
    EVLKYDLLKI CLEGPREKLN RTEHAQLAVM VSSLAALEQL REERPKAIET 150
    CVAAAGFSLG EITALVYADA LPFDKALRLV QVRATAMQAA CDQAAGAMAM 200
    TLYGPDTNLG EACARAQQWC LDKGVESPYC GIANYMYPHC KVVAGNVEAL 250
    EFLEQNAKSF KIRRMKRLAV SGAFHTPLMQ SAVEPFTKAL KTVRLQDPVI 300
    RVYSNVDGKP YRHAKHILTQ LPKQIVRPVK WEQTLHEMYE RKQGVDFPRT 350
    FECGPGKGLV QVLEKVNAKA AQSSFNVIA 379
    Length:379
    Mass (Da):42,086
    Last modified:June 7, 2004 - v2
    Checksum:iDC9BCD8624C7B623
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611A → T in AAM11123. (PubMed:12537569)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49377.1.
    AY094770 mRNA. Translation: AAM11123.1.
    BT050494 mRNA. Translation: ACJ13201.1.
    RefSeqiNP_648950.1. NM_140693.3.
    UniGeneiDm.12916.

    Genome annotation databases

    EnsemblMetazoaiFBtr0075278; FBpp0075038; FBgn0036691.
    GeneIDi39910.
    KEGGidme:Dmel_CG7842.
    UCSCiCG7842-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49377.1 .
    AY094770 mRNA. Translation: AAM11123.1 .
    BT050494 mRNA. Translation: ACJ13201.1 .
    RefSeqi NP_648950.1. NM_140693.3.
    UniGenei Dm.12916.

    3D structure databases

    ProteinModelPortali Q8T3L6.
    SMRi Q8T3L6. Positions 16-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7227.FBpp0075038.

    Proteomic databases

    PaxDbi Q8T3L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0075278 ; FBpp0075038 ; FBgn0036691 .
    GeneIDi 39910.
    KEGGi dme:Dmel_CG7842.
    UCSCi CG7842-RA. d. melanogaster.

    Organism-specific databases

    CTDi 39910.
    FlyBasei FBgn0036691. beg.

    Phylogenomic databases

    eggNOGi COG0331.
    GeneTreei ENSGT00390000013715.
    InParanoidi Q8T3L6.
    KOi K00645.
    OMAi AMTLYGP.
    OrthoDBi EOG7D85X6.
    PhylomeDBi Q8T3L6.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    GenomeRNAii 39910.
    NextBioi 816051.
    PROi Q8T3L6.

    Gene expression databases

    Bgeei Q8T3L6.

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Ovary.
    4. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
    5. "Conditional switches for extracellular matrix patterning in Drosophila melanogaster."
      Khokhar A., Chen N., Yuan J.-P., Li Y., Landis G.N., Beaulieu G., Kaur H., Tower J.
      Genetics 178:1283-1293(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiFABD_DROME
    AccessioniPrimary (citable) accession number: Q8T3L6
    Secondary accession number(s): B6IDQ4, Q9VVD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3