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Protein

Endophilin-A

Gene

EndoA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis.2 Publications

GO - Molecular functioni

  • lysophosphatidic acid acyltransferase activity Source: FlyBase
  • phospholipid binding Source: FlyBase

GO - Biological processi

  • autophagosome assembly Source: FlyBase
  • cellular response to starvation Source: FlyBase
  • endocytosis Source: FlyBase
  • membrane bending Source: FlyBase
  • membrane tubulation Source: FlyBase
  • plasma membrane tubulation Source: FlyBase
  • regulation of synapse structure or activity Source: FlyBase
  • synaptic vesicle endocytosis Source: FlyBase

Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

ReactomeiR-DME-177504 Retrograde neurotrophin signalling
R-DME-182971 EGFR downregulation
R-DME-432720 Lysosome Vesicle Biogenesis
R-DME-432722 Golgi Associated Vesicle Biogenesis
R-DME-437239 Recycling pathway of L1
R-DME-8856825 Cargo recognition for clathrin-mediated endocytosis
R-DME-8856828 Clathrin-mediated endocytosis
SignaLinkiQ8T390

Names & Taxonomyi

Protein namesi
Recommended name:
Endophilin-A
Alternative name(s):
SH3 domain-containing GRB2-like protein
Gene namesi
Name:EndoAImported
Synonyms:endo1 Publication
ORF Names:CG14296Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038659 EndoA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

Dramatic impairment of clathrin-mediated endocytosis, severe defects in motility and death at the early L2 larval stage.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002858381 – 369Endophilin-AAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285Phosphoserine1 Publication1
Modified residuei289Phosphoserine1 Publication1
Modified residuei293Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8T390
PRIDEiQ8T390

PTM databases

iPTMnetiQ8T390

Expressioni

Tissue specificityi

Expression is abundant in central nervous system (brain lobes and the ventral nerve cord) starting at embryonic stage 13 through to third instar larvae. Also expressed in photoreceptors in the eye imaginal disks and the Bolwig organs of the peripheral nervous system.2 Publications

Gene expression databases

BgeeiFBgn0038659
ExpressionAtlasiQ8T390 differential
GenevisibleiQ8T390 DM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
l(3)05822Q9VE963EBI-150782,EBI-156726

Protein-protein interaction databases

BioGridi67269, 12 interactors
IntActiQ8T390, 8 interactors
STRINGi7227.FBpp0083112

Structurei

3D structure databases

ProteinModelPortaliQ8T390
SMRiQ8T390
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 248BARPROSITE-ProRule annotationAdd BLAST231
Domaini305 – 364SH3PROSITE-ProRule annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili227 – 247Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the endophilin family.Sequence analysis

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG1118 Eukaryota
ENOG410XNYB LUCA
GeneTreeiENSGT00550000074464
InParanoidiQ8T390
KOiK11247
OMAiIRGQVKN
OrthoDBiEOG091G16FW
PhylomeDBiQ8T390

Family and domain databases

CDDicd11803 SH3_Endophilin_A, 1 hit
Gene3Di1.20.1270.60, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR004148 BAR_dom
IPR028501 Endophilin-A
IPR035824 Endophilin_A_SH3
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR43965 PTHR43965, 1 hit
PfamiView protein in Pfam
PF03114 BAR, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00721 BAR, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51021 BAR, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8T390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFAGLKKQI NKANQYMTEK MGGAEGTKLD MDFMEMERKT DVTVELVEEL
60 70 80 90 100
QLKTKEFLQP NPTARAKMAA VKGISKLSGQ AKSNTYPQPE GLLAECMLTY
110 120 130 140 150
GKKLGEDNSV FAQALVEFGE ALKQMADVKY SLDDNIKQNF LEPLHHMQTK
160 170 180 190 200
DLKEVMHHRK KLQGRRLDFD CKRRRQAKDD EIRGAEDKFG ESLQLAQVGM
210 220 230 240 250
FNLLENDTEH VSQLVTFAEA LYDFHSQCAD VLRGLQETLQ EKRSEAESRP
260 270 280 290 300
RNEFVPKTLL DLNLDGGGGG LNEDGTPSHI SSSASPLPSP MRSPAKSMAV
310 320 330 340 350
TPQRQQQPCC QALYDFEPEN PGELAFKEND IITLLNRVDD NWFEGAVNGR
360
TGYFPQSYVQ VQVPLPNGN
Length:369
Mass (Da):41,409
Last modified:June 1, 2002 - v1
Checksum:iF6B82FAEA6FF31A9
GO

RNA editingi

Edited at positions 129 and 137.3 Publications
Partially edited. Target of Adar.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti129K → R in RNA edited version. 2 Publications1
Natural varianti137K → E in RNA edited version. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426170 mRNA Translation: AAL24818.1
AJ437141 mRNA Translation: CAD24682.1
AE014297 Genomic DNA Translation: AAF55606.2
BT003300 mRNA Translation: AAO25060.1
RefSeqiNP_001262717.1, NM_001275788.1
NP_620122.2, NM_138767.3
NP_732383.1, NM_169838.2
UniGeneiDm.3503

Genome annotation databases

EnsemblMetazoaiFBtr0083698; FBpp0083112; FBgn0038659
FBtr0083699; FBpp0083113; FBgn0038659
FBtr0334522; FBpp0306589; FBgn0038659
GeneIDi42265
KEGGidme:Dmel_CG14296

Keywords - Coding sequence diversityi

RNA editing

Similar proteinsi

Entry informationi

Entry nameiSH3G3_DROME
AccessioniPrimary (citable) accession number: Q8T390
Secondary accession number(s): Q95V65, Q9VE25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health