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Q8T2K9

- MASY_DICDI

UniProt

Q8T2K9 - MASY_DICDI

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Protein

Malate synthase

Gene

masA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621Proton acceptorBy similarity
Active sitei449 – 4491Proton donorBy similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase (EC:2.3.3.9)
Gene namesi
Name:masA
ORF Names:DDB_G0275887
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275887. masA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 543543Malate synthasePRO_0000365606Add
BLAST

Proteomic databases

PRIDEiQ8T2K9.

Expressioni

Developmental stagei

Late prestalk cell-specific expression.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0230181.

Structurei

3D structure databases

ProteinModelPortaliQ8T2K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.Curated

Phylogenomic databases

eggNOGiCOG2225.
InParanoidiQ8T2K9.
KOiK01638.
OMAiSIWQWIR.
PhylomeDBiQ8T2K9.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8T2K9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRGIEIRGK VDKNVKSILT EECLTFLGEL ERRFGGIRKN LLQKRLDRQI
60 70 80 90 100
DINNGILPSF LKDSDCKRAT DKNWKCSSVP LEIQDRRVEI TGPTDRKMVI
110 120 130 140 150
NALNSGAKVF MADFEDANCP NWENSIHGQQ NMIDANNRTI SFTSAEGRKY
160 170 180 190 200
ELNKQVAVLF VRPRGWHLNE DHLAIDGLSM SGSLFDFGCY IFHNHQILKN
210 220 230 240 250
RNSNPYFYLP KMESHLEARL WNDVFVFSQN YLGMPIGTIK ATVLIETILA
260 270 280 290 300
SFEMDEILYE LRDHSAGLNC GRWDYIFSFI KKFQSYPDKM LPDRAKVTMT
310 320 330 340 350
SPFMDSYVKL LIYTCHKRGV HAMGGMAAQI PIKNNEQANN AAMEKVRLDK
360 370 380 390 400
QREVRAGHDG TWVAHPALIP IAMEQFNTHM KSQNQISYIP SSTAPNFEEI
410 420 430 440 450
AKSLLSVDPV KPGDITEDGF RSNIVVGILY LEAWLNGNGC VPIHNLMEDA
460 470 480 490 500
ATAEISRSQI WQWIKHKAPL PDGKSFVTLQ YYNRIFKEES DKLEKAHPNS
510 520 530 540
KTLTDAIQIF NNLIVSPNFI DFLTPSCYKF VVDSERKTFS PKL
Length:543
Mass (Da):62,030
Last modified:June 1, 2003 - v2
Checksum:i6F8E37DCCC9904B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69694.2.
RefSeqiXP_643552.2. XM_638460.2.

Genome annotation databases

EnsemblProtistsiDDB0230181; DDB0230181; DDB_G0275887.
GeneIDi8620134.
KEGGiddi:DDB_G0275887.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69694.2 .
RefSeqi XP_643552.2. XM_638460.2.

3D structure databases

ProteinModelPortali Q8T2K9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0230181.

Proteomic databases

PRIDEi Q8T2K9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0230181 ; DDB0230181 ; DDB_G0275887 .
GeneIDi 8620134.
KEGGi ddi:DDB_G0275887.

Organism-specific databases

dictyBasei DDB_G0275887. masA.

Phylogenomic databases

eggNOGi COG2225.
InParanoidi Q8T2K9.
KOi K01638.
OMAi SIWQWIR.
PhylomeDBi Q8T2K9.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .

Miscellaneous databases

PROi Q8T2K9.

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Changing patterns of gene expression in Dictyostelium prestalk cell subtypes recognized by in situ hybridization with genes from microarray analyses."
    Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S., Morio T., Urushihara H., Tanaka Y., Loomis W.F.
    Eukaryot. Cell 2:627-637(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiMASY_DICDI
AccessioniPrimary (citable) accession number: Q8T2K9
Secondary accession number(s): Q552X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 1, 2003
Last modified: October 1, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3