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Q8T2I5

- LYSG3_DICDI

UniProt

Q8T2I5 - LYSG3_DICDI

Protein

Probable GH family 25 lysozyme 3

Gene

DDB_G0276439

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei116 – 1161By similarity

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell wall macromolecule catabolic process Source: InterPro
    3. cytolysis Source: UniProtKB-KW
    4. defense response to bacterium Source: UniProtKB-KW
    5. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable GH family 25 lysozyme 3 (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase 3
    Gene namesi
    ORF Names:DDB_G0276439
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0276439.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 480460Probable GH family 25 lysozyme 3PRO_0000330649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi423 – 4231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi446 – 4461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ8T2I5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi219 – 473255Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 25 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    OMAiIDISSGT.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR002053. Glyco_hydro_25.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF01183. Glyco_hydro_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8T2I5-1 [UniParc]FASTAAdd to Basket

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    MNKLILSILS VLLIVSIASA GNGIDISSGT NPSSSDLACL AKQNSKIIVQ    50
    TWSGGYGFNS NVPSIVQAAK SAGLSVDLYA FLCSQCSGIT DPAEAIKTLV 100
    SKLNGVKYGT LWIDVEQCNG CWSSTLSSNA QYVQTAVQTA SQLGVNVGVY 150
    SSEGEWPQTV GSLTSLSSFP LWYAHYDNNP SFSDQGYNFG GWSKAVMKQY 200
    QGTTTQCGVS VDLNWFPGSG SSTTSSSATS SSTTGRPLTS SSGAGTGGHS 250
    SSSGAGTGGH SSTTGGQTSG QTSGQTSGSS NQPLSSGSSQ DSSNSGSSNQ 300
    PLSSGSSQDS SNSGSSNQPL SSGSSQTSGQ TSGSSNQPLS SGSSQDSGSN 350
    SGSQGTTGSQ SGSSSSNPLT SGSQSGSSGS QSTSSGSQSG SSGATGTSST 400
    ASSTSATGSS STGSSTGSSS GSNDSGSNDS GSSSGSNNSG SSSGSNNSGS 450
    SSGSASSSGS SGSSGSGNYT SGSGNGAFLF 480
    Length:480
    Mass (Da):46,450
    Last modified:June 1, 2002 - v1
    Checksum:iDE6A8A54794891E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000015 Genomic DNA. Translation: EAL69173.1.
    RefSeqiXP_643144.1. XM_638052.1.

    Genome annotation databases

    EnsemblProtistsiDDB0252582; DDB0252582; DDB_G0276439.
    GeneIDi8620551.
    KEGGiddi:DDB_G0276439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000015 Genomic DNA. Translation: EAL69173.1 .
    RefSeqi XP_643144.1. XM_638052.1.

    3D structure databases

    ProteinModelPortali Q8T2I5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0252582 ; DDB0252582 ; DDB_G0276439 .
    GeneIDi 8620551.
    KEGGi ddi:DDB_G0276439.

    Organism-specific databases

    dictyBasei DDB_G0276439.

    Phylogenomic databases

    eggNOGi NOG12793.
    OMAi IDISSGT.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR002053. Glyco_hydro_25.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF01183. Glyco_hydro_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiLYSG3_DICDI
    AccessioniPrimary (citable) accession number: Q8T2I5
    Secondary accession number(s): Q551J0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3