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Q8T2I5

- LYSG3_DICDI

UniProt

Q8T2I5 - LYSG3_DICDI

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Protein

Probable GH family 25 lysozyme 3

Gene
DDB_G0276439
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161 By similarity

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cell wall macromolecule catabolic process Source: InterPro
  3. cytolysis Source: UniProtKB-KW
  4. defense response to bacterium Source: UniProtKB-KW
  5. peptidoglycan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable GH family 25 lysozyme 3 (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase 3
Gene namesi
ORF Names:DDB_G0276439
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0276439.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 480460Probable GH family 25 lysozyme 3PRO_0000330649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi423 – 4231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi437 – 4371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi446 – 4461N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ8T2I5.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi219 – 473255Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
OMAiIDISSGT.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR002053. Glyco_hydro_25.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T2I5-1 [UniParc]FASTAAdd to Basket

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MNKLILSILS VLLIVSIASA GNGIDISSGT NPSSSDLACL AKQNSKIIVQ    50
TWSGGYGFNS NVPSIVQAAK SAGLSVDLYA FLCSQCSGIT DPAEAIKTLV 100
SKLNGVKYGT LWIDVEQCNG CWSSTLSSNA QYVQTAVQTA SQLGVNVGVY 150
SSEGEWPQTV GSLTSLSSFP LWYAHYDNNP SFSDQGYNFG GWSKAVMKQY 200
QGTTTQCGVS VDLNWFPGSG SSTTSSSATS SSTTGRPLTS SSGAGTGGHS 250
SSSGAGTGGH SSTTGGQTSG QTSGQTSGSS NQPLSSGSSQ DSSNSGSSNQ 300
PLSSGSSQDS SNSGSSNQPL SSGSSQTSGQ TSGSSNQPLS SGSSQDSGSN 350
SGSQGTTGSQ SGSSSSNPLT SGSQSGSSGS QSTSSGSQSG SSGATGTSST 400
ASSTSATGSS STGSSTGSSS GSNDSGSNDS GSSSGSNNSG SSSGSNNSGS 450
SSGSASSSGS SGSSGSGNYT SGSGNGAFLF 480
Length:480
Mass (Da):46,450
Last modified:June 1, 2002 - v1
Checksum:iDE6A8A54794891E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69173.1.
RefSeqiXP_643144.1. XM_638052.1.

Genome annotation databases

EnsemblProtistsiDDB0252582; DDB0252582; DDB_G0276439.
GeneIDi8620551.
KEGGiddi:DDB_G0276439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000015 Genomic DNA. Translation: EAL69173.1 .
RefSeqi XP_643144.1. XM_638052.1.

3D structure databases

ProteinModelPortali Q8T2I5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0252582 ; DDB0252582 ; DDB_G0276439 .
GeneIDi 8620551.
KEGGi ddi:DDB_G0276439.

Organism-specific databases

dictyBasei DDB_G0276439.

Phylogenomic databases

eggNOGi NOG12793.
OMAi IDISSGT.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR002053. Glyco_hydro_25.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF01183. Glyco_hydro_25. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiLYSG3_DICDI
AccessioniPrimary (citable) accession number: Q8T2I5
Secondary accession number(s): Q551J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3