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Q8T2I5 (LYSG3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable GH family 25 lysozyme 3

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase 3
Gene names
ORF Names:DDB_G0276439
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length480 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 25 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 480460Probable GH family 25 lysozyme 3
PRO_0000330649

Regions

Compositional bias219 – 473255Ser-rich

Sites

Active site1161 By similarity

Amino acid modifications

Glycosylation4231N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4461N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8T2I5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: DE6A8A54794891E3

FASTA48046,450
        10         20         30         40         50         60 
MNKLILSILS VLLIVSIASA GNGIDISSGT NPSSSDLACL AKQNSKIIVQ TWSGGYGFNS 

        70         80         90        100        110        120 
NVPSIVQAAK SAGLSVDLYA FLCSQCSGIT DPAEAIKTLV SKLNGVKYGT LWIDVEQCNG 

       130        140        150        160        170        180 
CWSSTLSSNA QYVQTAVQTA SQLGVNVGVY SSEGEWPQTV GSLTSLSSFP LWYAHYDNNP 

       190        200        210        220        230        240 
SFSDQGYNFG GWSKAVMKQY QGTTTQCGVS VDLNWFPGSG SSTTSSSATS SSTTGRPLTS 

       250        260        270        280        290        300 
SSGAGTGGHS SSSGAGTGGH SSTTGGQTSG QTSGQTSGSS NQPLSSGSSQ DSSNSGSSNQ 

       310        320        330        340        350        360 
PLSSGSSQDS SNSGSSNQPL SSGSSQTSGQ TSGSSNQPLS SGSSQDSGSN SGSQGTTGSQ 

       370        380        390        400        410        420 
SGSSSSNPLT SGSQSGSSGS QSTSSGSQSG SSGATGTSST ASSTSATGSS STGSSTGSSS 

       430        440        450        460        470        480 
GSNDSGSNDS GSSSGSNNSG SSSGSNNSGS SSGSASSSGS SGSSGSGNYT SGSGNGAFLF 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000015 Genomic DNA. Translation: EAL69173.1.

3D structure databases

ProteinModelPortalQ8T2I5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0252582; DDB0252582; DDB_G0276439.
KEGGddi:DDB_G0276439.

Organism-specific databases

dictyBaseDDB_G0276439.

Phylogenomic databases

eggNOGNOG12793.
OMAIDISSGT.
ProtClustDBCLSZ2431205.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR002053. Glyco_hydro_25.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF01183. Glyco_hydro_25. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLYSG3_DICDI
AccessionPrimary (citable) accession number: Q8T2I5
Secondary accession number(s): Q551J0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase