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Protein

Lysozyme B

Gene

alyB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  • lysozyme activity Source: UniProtKB

GO - Biological processi

  • cytolysis Source: UniProtKB-KW
  • defense response to Gram-positive bacterium Source: UniProtKB
  • peptidoglycan catabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme B (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase B
Gene namesi
Name:alyB
ORF Names:DDB_G0275119
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275119. alyB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  • cytoplasmic vesicle Source: UniProtKB
  • vesicle lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 138119Lysozyme BPRO_0000315916Add
BLAST
Propeptidei139 – 18143By similarityPRO_0000315917Add
BLAST

Post-translational modificationi

Contains six disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Sequence similaritiesi

Belongs to the dictyostelium lysozyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ8T1G6.
OMAiNICTASK.
PhylomeDBiQ8T1G6.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T1G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRISFFLLIL AVIIGYAYGY SCPKPCYGNM CCSTSPGNKY YLTDFCGSTS
60 70 80 90 100
ACGPVPSCSG ALYFTADSQR FGCGKHLNLC RGSKCVKAQI YDAGPAMWVE
110 120 130 140 150
QDAGMMIIDA SPTICHVLTG GSSCGWSDKF EITATVTSLT DSRPLGPFNV
160 170 180
TEEEKAQLFI DHEIAMAQCE AEKTCNGFDL E
Length:181
Mass (Da):19,535
Last modified:June 1, 2002 - v1
Checksum:iC505C07DBE8E4580
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69840.1.
RefSeqiXP_643741.1. XM_638649.1.

Genome annotation databases

EnsemblProtistsiDDB0231278; DDB0231278; DDB_G0275119.
GeneIDi8619785.
KEGGiddi:DDB_G0275119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69840.1.
RefSeqiXP_643741.1. XM_638649.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231278; DDB0231278; DDB_G0275119.
GeneIDi8619785.
KEGGiddi:DDB_G0275119.

Organism-specific databases

dictyBaseiDDB_G0275119. alyB.

Phylogenomic databases

InParanoidiQ8T1G6.
OMAiNICTASK.
PhylomeDBiQ8T1G6.

Miscellaneous databases

PROiQ8T1G6.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiLYSB_DICDI
AccessioniPrimary (citable) accession number: Q8T1G6
Secondary accession number(s): Q554H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.