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Q8T1G5

- LYSC_DICDI

UniProt

Q8T1G5 - LYSC_DICDI

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Protein
Lysozyme C
Gene
alyC, DDB_G0275121
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has antibacterial activity By similarity.

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to Gram-positive bacterium Source: UniProtKB
  3. peptidoglycan catabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme C (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase C
Gene namesi
Name:alyC
ORF Names:DDB_G0275121
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0275121. alyC.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  2. cytoplasmic vesicle Source: UniProtKB
  3. vesicle lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarity
Add
BLAST
Chaini20 – 138119Lysozyme C
PRO_0000315918Add
BLAST
Propeptidei139 – 18143 By similarity
PRO_0000315919Add
BLAST

Post-translational modificationi

Contains six disulfide bonds By similarity.

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8T1G5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OMAiTICHELT.
PhylomeDBiQ8T1G5.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8T1G5-1 [UniParc]FASTAAdd to Basket

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MRIAFFLLIL SIIVGLAYGY SCPKPCYGNM CCSTSPDHKY YLTDFCGSTS    50
ACGPKPSCSG KLYFTADSQR FGCGKHLNLC RGKKCVKAKV YDAGPAEWVE 100
KDAGKMIIDA SPTICHELTG GSSCGWSDKF EITATVTSLT DSRPLGPFNV 150
TEEEMDQLFI DHEIAMAQCE AEKTCNGFDL E 181
Length:181
Mass (Da):19,752
Last modified:June 1, 2002 - v1
Checksum:i6160694D7857939C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69841.1.
RefSeqiXP_643740.1. XM_638648.1.

Genome annotation databases

EnsemblProtistsiDDB0231279; DDB0231279; DDB_G0275121.
GeneIDi8619784.
KEGGiddi:DDB_G0275121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000013 Genomic DNA. Translation: EAL69841.1 .
RefSeqi XP_643740.1. XM_638648.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q8T1G5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231279 ; DDB0231279 ; DDB_G0275121 .
GeneIDi 8619784.
KEGGi ddi:DDB_G0275121.

Organism-specific databases

dictyBasei DDB_G0275121. alyC.

Phylogenomic databases

OMAi TICHELT.
PhylomeDBi Q8T1G5.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiLYSC_DICDI
AccessioniPrimary (citable) accession number: Q8T1G5
Secondary accession number(s): Q554H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi