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Q8T1G5

- LYSC_DICDI

UniProt

Q8T1G5 - LYSC_DICDI

Protein

Lysozyme C

Gene

alyC

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Has antibacterial activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. defense response to Gram-positive bacterium Source: UniProtKB
    3. peptidoglycan catabolic process Source: dictyBase

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme C (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase C
    Gene namesi
    Name:alyC
    ORF Names:DDB_G0275121
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0275121. alyC.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB
    3. vesicle lumen Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 138119Lysozyme CPRO_0000315918Add
    BLAST
    Propeptidei139 – 18143By similarityPRO_0000315919Add
    BLAST

    Post-translational modificationi

    Contains six disulfide bonds.By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ8T1G5.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dictyostelium lysozyme family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OMAiTICHELT.
    PhylomeDBiQ8T1G5.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8T1G5-1 [UniParc]FASTAAdd to Basket

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    MRIAFFLLIL SIIVGLAYGY SCPKPCYGNM CCSTSPDHKY YLTDFCGSTS    50
    ACGPKPSCSG KLYFTADSQR FGCGKHLNLC RGKKCVKAKV YDAGPAEWVE 100
    KDAGKMIIDA SPTICHELTG GSSCGWSDKF EITATVTSLT DSRPLGPFNV 150
    TEEEMDQLFI DHEIAMAQCE AEKTCNGFDL E 181
    Length:181
    Mass (Da):19,752
    Last modified:June 1, 2002 - v1
    Checksum:i6160694D7857939C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69841.1.
    RefSeqiXP_643740.1. XM_638648.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231279; DDB0231279; DDB_G0275121.
    GeneIDi8619784.
    KEGGiddi:DDB_G0275121.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000013 Genomic DNA. Translation: EAL69841.1 .
    RefSeqi XP_643740.1. XM_638648.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8T1G5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231279 ; DDB0231279 ; DDB_G0275121 .
    GeneIDi 8619784.
    KEGGi ddi:DDB_G0275121.

    Organism-specific databases

    dictyBasei DDB_G0275121. alyC.

    Phylogenomic databases

    OMAi TICHELT.
    PhylomeDBi Q8T1G5.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiLYSC_DICDI
    AccessioniPrimary (citable) accession number: Q8T1G5
    Secondary accession number(s): Q554H1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3