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Protein

Phospholipid-transporting ATPase

Gene

CG42321

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

  • phospholipid translocation Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
Name:CG42321Imported
ORF Names:Dmel_CG42321Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0259221. CG42321.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei304 – 325HelicalUniRule annotationAdd BLAST22
Transmembranei345 – 365HelicalUniRule annotationAdd BLAST21
Transmembranei881 – 902HelicalUniRule annotationAdd BLAST22
Transmembranei923 – 944HelicalUniRule annotationAdd BLAST22
Transmembranei964 – 984HelicalUniRule annotationAdd BLAST21
Transmembranei996 – 1016HelicalUniRule annotationAdd BLAST21
Transmembranei1036 – 1056HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0259221.
ExpressionAtlasiQ8T0I4. differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 108PhoLip_ATPase_NInterPro annotationAdd BLAST57
Domaini815 – 1065PhoLip_ATPase_CInterPro annotationAdd BLAST251

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
GeneTreeiENSGT00870000136387.
OrthoDBiEOG091G0139.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR036412. HAD-like_sf.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 2 hits.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8T0I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSIFRFRLP FRRSELPETG LLNTYDEDFT SSAGYDADDG ERRIINLNGP
60 70 80 90 100
QPTKYGNNRI TTAKYSFISF LPAFLFEQFR RYSNCFFLLI AILQQIPEVS
110 120 130 140 150
PTGRYTTLVP LMFILSVSAI KEIIEDIKRH RADNEINHRS IERLDSGSWC
160 170 180 190 200
TVRWSELTVG DIIKVGINTF FPADLILLSS SEPQAMCFIE TANLDGETNL
210 220 230 240 250
KIRQALPATA ELLETKDLQR LEGRIECELP NRHLYEFNGV LRETGKPPAA
260 270 280 290 300
LGNDQVLQRG AILRNTAWVF GIVVYSGQET KLMKNSTSAP LKRSTVDKLT
310 320 330 340 350
NTQILMLFMI LISLCIISGL CNLFWTREHS ETDWYLGLTD FKTKSLGYNL
360 370 380 390 400
LTFFILYNNL IPISLQVTLE LVRFLQAIFI NYDIEMYHEE SNTPAMARTS
410 420 430 440 450
NLNEELGMVK YIFSDKTGTL TQNVMEFKKC SIAGYVYTAE RTPEESQLVQ
460 470 480 490 500
NILGRHETSA VIEEFLELLS VCHTVIPERK ENGNMIYHAA SPDERALVEG
510 520 530 540 550
AQKFGYIFDT RTPKYVEINA LGVRKRYEVL NVLEFTSSRK RMSLIVRTPE
560 570 580 590 600
NKIKLFCKGA DTVIYERLAP QGQAFREQTL RHLEEFASDG LRTLCLAVAD
610 620 630 640 650
IRPDVYQEWS QTFDKASVAL QNRESKLEDA ANLIENNLRL LGATAIEDRL
660 670 680 690 700
QDGVPETIAS LLDAGIYIWV LTGDKQETAI NIGYSCRLIS HSMDIIILNE
710 720 730 740 750
ESLDATREVI HRHYGEFKSS SAKDANVALV IDGTTLKYAL SCDLRNDFQD
760 770 780 790 800
LCILCRVVIC CRVSPMQKAE VVEMVTQSTN AVTLAIGDGA NDVAMIQKAN
810 820 830 840 850
VGIGISGVEG LQAACASDYS IAQFRYLQRL LLVHGAWNYA RISKLILYSF
860 870 880 890 900
YKNVCLYVIE LWFAVYSGWS GQILFERWTI GLYNVLFTAM PPFAMGLFEK
910 920 930 940 950
FCTAETMIRY PMLYKTSQNA KLFNVKVFWI WIFNALLHSV FLFWLPLAAY
960 970 980 990 1000
TKEVIWSDGK TSDYLLMGNL VYTYVIVTVC LKAGLITNSW TWLTHLAIWG
1010 1020 1030 1040 1050
SIVLWFGFLL IYSHVWPMFK FASNFRGMDI QLLSTPVFYF CLMLVPITTL
1060 1070 1080 1090 1100
LIDVICKLVH NTVFKTLTEA VRETEIRRSD ISEVMNEPRS SFTETARLLR
1110 1120 1130 1140 1150
NVFTRRANTR VETDLELSHG YAFSQEEGGA VPQSIIIRAY DTNLPKPEGN
Length:1,150
Mass (Da):130,907
Last modified:June 1, 2002 - v1
Checksum:i3A07D6FCCCA54A8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY069236 mRNA. Translation: AAL39381.1.
AE013599 Genomic DNA. Translation: AAM68573.1.
AE013599 Genomic DNA. Translation: ACL83108.1.
RefSeqiNP_001137654.1. NM_001144182.3.
NP_610873.1. NM_137029.4.
UniGeneiDm.7647.

Genome annotation databases

EnsemblMetazoaiFBtr0299754; FBpp0289032; FBgn0259221.
FBtr0299761; FBpp0289039; FBgn0259221.
GeneIDi36488.
UCSCiCG42321-RE. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ8T0I4_DROME
AccessioniPrimary (citable) accession number: Q8T0I4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 25, 2017
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported