Q8T0I4 (Q8T0I4_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CG42321, isoform E EMBL AAM68573.1
EC=3.6.3.1 EMBL AAM68573.1

Submitted name:
CG42321, isoform M EMBL ACL83108.1
EC=3.6.3.1 EMBL ACL83108.1
Submitted name:
GH28327p EMBL AAL39381.1

Gene names

ORF Names:

CG17034 FlyBase FBgn0033837 EMBL AAL39381.1, CG42321 FlyBase FBgn0259221, Dmel_CG42321 EMBL AAM68573.1

Organism

Drosophila melanogaster (Fruit fly) EMBL AAL39381.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	1150 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out). SAAS SAAS023299

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS023306
Ligand	ATP-binding SAAS SAAS023306 Magnesium SAAS SAAS023299 Nucleotide-binding
Molecular function	Hydrolase SAAS SAAS023299 EMBL AAM68573.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cation transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8T0I4 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 3A07D6FCCCA54A8C	FASTA	1,150	130,907
	10 20 30 40 50 60 MPSIFRFRLP FRRSELPETG LLNTYDEDFT SSAGYDADDG ERRIINLNGP QPTKYGNNRI 70 80 90 100 110 120 TTAKYSFISF LPAFLFEQFR RYSNCFFLLI AILQQIPEVS PTGRYTTLVP LMFILSVSAI 130 140 150 160 170 180 KEIIEDIKRH RADNEINHRS IERLDSGSWC TVRWSELTVG DIIKVGINTF FPADLILLSS 190 200 210 220 230 240 SEPQAMCFIE TANLDGETNL KIRQALPATA ELLETKDLQR LEGRIECELP NRHLYEFNGV 250 260 270 280 290 300 LRETGKPPAA LGNDQVLQRG AILRNTAWVF GIVVYSGQET KLMKNSTSAP LKRSTVDKLT 310 320 330 340 350 360 NTQILMLFMI LISLCIISGL CNLFWTREHS ETDWYLGLTD FKTKSLGYNL LTFFILYNNL 370 380 390 400 410 420 IPISLQVTLE LVRFLQAIFI NYDIEMYHEE SNTPAMARTS NLNEELGMVK YIFSDKTGTL 430 440 450 460 470 480 TQNVMEFKKC SIAGYVYTAE RTPEESQLVQ NILGRHETSA VIEEFLELLS VCHTVIPERK 490 500 510 520 530 540 ENGNMIYHAA SPDERALVEG AQKFGYIFDT RTPKYVEINA LGVRKRYEVL NVLEFTSSRK 550 560 570 580 590 600 RMSLIVRTPE NKIKLFCKGA DTVIYERLAP QGQAFREQTL RHLEEFASDG LRTLCLAVAD 610 620 630 640 650 660 IRPDVYQEWS QTFDKASVAL QNRESKLEDA ANLIENNLRL LGATAIEDRL QDGVPETIAS 670 680 690 700 710 720 LLDAGIYIWV LTGDKQETAI NIGYSCRLIS HSMDIIILNE ESLDATREVI HRHYGEFKSS 730 740 750 760 770 780 SAKDANVALV IDGTTLKYAL SCDLRNDFQD LCILCRVVIC CRVSPMQKAE VVEMVTQSTN 790 800 810 820 830 840 AVTLAIGDGA NDVAMIQKAN VGIGISGVEG LQAACASDYS IAQFRYLQRL LLVHGAWNYA 850 860 870 880 890 900 RISKLILYSF YKNVCLYVIE LWFAVYSGWS GQILFERWTI GLYNVLFTAM PPFAMGLFEK 910 920 930 940 950 960 FCTAETMIRY PMLYKTSQNA KLFNVKVFWI WIFNALLHSV FLFWLPLAAY TKEVIWSDGK 970 980 990 1000 1010 1020 TSDYLLMGNL VYTYVIVTVC LKAGLITNSW TWLTHLAIWG SIVLWFGFLL IYSHVWPMFK 1030 1040 1050 1060 1070 1080 FASNFRGMDI QLLSTPVFYF CLMLVPITTL LIDVICKLVH NTVFKTLTEA VRETEIRRSD 1090 1100 1110 1120 1130 1140 ISEVMNEPRS SFTETARLLR NVFTRRANTR VETDLELSHG YAFSQEEGGA VPQSIIIRAY 1150 DTNLPKPEGN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL39381.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY069236 mRNA. Translation: AAL39381.1. AE013599 Genomic DNA. Translation: AAM68573.1. AE013599 Genomic DNA. Translation: ACL83108.1.
RefSeq	NP_001137654.1. NM_001144182.2. NP_610873.1. NM_137029.3.
3D structure databases
ProteinModelPortal	Q8T0I4.
SMR	Q8T0I4. Positions 766-809.
ModBase	Search...
Proteomic databases
PRIDE	Q8T0I4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0299754; FBpp0289032; FBgn0259221. FBtr0299761; FBpp0289039; FBgn0259221.
GeneID	36488.
KEGG	dme:Dmel_CG42321.
UCSC	CG42321-RE. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0259221. CG42321.
Phylogenomic databases
GeneTree	EMGT00050000009037.
InParanoid	Q8T0I4.
PhylomeDB	Q8T0I4.
Gene expression databases
ArrayExpress	Q8T0I4.
Bgee	Q8T0I4.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K14802.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 2 hits. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	798813.

Entry information

Entry name

Q8T0I4_DROME

Accession

Primary (citable) accession number: Q8T0I4

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2002
Last sequence update:	June 1, 2002
Last modified:	January 25, 2012
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)