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Protein

Palmitoyltransferase

Gene

CG5196

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

  • protein-cysteine S-palmitoyltransferase activity Source: FlyBase

GO - Biological processi

  • Golgi organization Source: FlyBase
  • protein palmitoylation Source: FlyBase

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
ORF Names:CG5196Imported, Dmel_CG5196Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0038039. CG5196.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei103 – 127HelicalUniRule annotationAdd BLAST25
Transmembranei148 – 176HelicalUniRule annotationAdd BLAST29

GO - Cellular componenti

  • endomembrane system Source: FlyBase
  • endoplasmic reticulum Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0038039.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 191DHHCInterPro annotationAdd BLAST134

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1314. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00880000137864.
OrthoDBiEOG091G0HOK.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SWX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSMWWPPNK SFAGFAHQAL FLLLSTLATF NYVMATLTGP GLMPKQWHPK
60 70 80 90 100
DPKDAQFLQY CKKCEGYKAP RSHHCRKCDR CVKKMDHHCP WINHCVGWAN
110 120 130 140 150
HAYFTYFLLF SILGSLQGTV VLCCSFWRGI YRYYYLTHGL AHLASVQFTL
160 170 180 190 200
LSIIMCILGM GLAIGVVIGL SMLLFIQLKT IVNNQTGIEI WIVEKAIYRR
210 220 230 240 250
YRNADCDDEF LYPYDLGWRA NLRLVFNDEC QKRGDGIEWP VVEGCDQYTL
260 270 280 290 300
TREQLAQKEE KRARTRTFKC TRPVTGRWLP IFSQGWRVCV AAPCSDEPRI
310 320 330 340 350
SLRPNDMIKV TRFRNHWLFG ERVLSEQELA GVKKRQRKGP IRGWFPRRSA
360 370 380 390
VEVIEAVHEG SGDGNSETPA PAAQNGNAHS HLKQQQRNGH AKKYM
Length:395
Mass (Da):45,552
Last modified:June 1, 2002 - v1
Checksum:i22FB4AF3FE10C3C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY095004 mRNA. Translation: AAM11332.1.
AE014297 Genomic DNA. Translation: AAS65144.1.
RefSeqiNP_996201.1. NM_206479.2.
UniGeneiDm.7090.

Genome annotation databases

EnsemblMetazoaiFBtr0082584; FBpp0082056; FBgn0038039.
FBtr0082585; FBpp0082057; FBgn0038039.
GeneIDi41522.
UCSCiCG5196-RB. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ8SWX8_DROME
AccessioniPrimary (citable) accession number: Q8SWX8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 5, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported