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Protein

Spore wall and anchoring disk complex protein EnP1

Gene

EnP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Spore wall protein involved in the adhesion to host cells surface glycoaminoglycans (GAGs). Microsporidian spore adherence is an integral part of activation and host cell invasion which requires the extrusion at the spore apex of a very long and coiled structure, the polar tube, through which the sporoplasm is pushed to enter into the potential host cell.1 Publication

GO - Biological processi

Keywordsi

Biological processCell adhesion, Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Spore wall and anchoring disk complex protein EnP1
Alternative name(s):
Host cell adhesion protein EnP1
Gene namesi
Name:EnP1
Ordered Locus Names:ECU01_0820
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0820

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000037752317 – 357Spore wall and anchoring disk complex protein EnP1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed during merogony and a large part of sporogony.2 Publications

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi150 – 158HBM19
Motifi329 – 334HBM26

Domaini

Heparin-binding motifs (HBMs) are characterized by an XBBXBX or XBBBXXBX sequence, where X is any neutral amino acid and B is a positively charged basic amino acid, and are defined as the consensus sequence necessary for protein-heparin interactions. HBM1 motif is necessary for spore adherence to host cells.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000112375
InParanoidiQ8SWL3
OrthoDBiEOG092C3XNT

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SWL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLGFLIVG LSAISALKTK ALHLTCEQEL RPYSAVVDAN CMAFALNGSN
60 70 80 90 100
IHEAIKYLQA MNIKKAYVLY WNDHDLRGTP MVLYDNGALA PFDPYTNTAK
110 120 130 140 150
YVLCVEACPC PGSKAASVGG FQAATSSEKI YVEGSARPAQ CSEVCIEPVE
160 170 180 190 200
RRPHYKKIVV NPSPSNCIPC EPECYDSSSS SECNKKRCKT FPRICKEKCG
210 220 230 240 250
SRRRGCPRKV EVLKSQKTYT FDIEKYRRRG EVVVRVCSKD SKEKFERFIL
260 270 280 290 300
SRNGEIRGNN NKNCILEPLP KCLRCPGQLH KLKKHIERKV CQEVCMYINA
310 320 330 340 350
KCDIFVLVGD CDFYRVVVND RRRYRNLHLK KVRGHKLREL IKHGLFGVEF

GPLDLDR
Length:357
Mass (Da):40,584
Last modified:June 1, 2002 - v1
Checksum:iABF93E135E9735B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA Translation: CAD24952.1
RefSeqiXP_965917.1, XM_960824.1

Genome annotation databases

EnsemblFungiiCAD24952; CAD24952; CAD24952
GeneIDi860258
KEGGiecu:ECU01_0820

Similar proteinsi

Entry informationi

Entry nameiENP1_ENCCU
AccessioniPrimary (citable) accession number: Q8SWL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health