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Q8SVN8 (NTE1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:ECU05_0070
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length905 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 905905Lysophospholipase NTE1
PRO_0000295321

Regions

Transmembrane1 – 2121Helical; Potential
Topological domain22 – 905884Cytoplasmic By similarity
Domain610 – 774165Patatin
Nucleotide binding198 – 319122cNMP 1
Nucleotide binding310 – 428119cNMP 2
Motif641 – 6455GXSXG

Sites

Active site6431 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SVN8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 94B9D7775EA8E92C

FASTA905103,088
        10         20         30         40         50         60 
MVSLSLLIAI IVVTGLLAGF RHYGSSRCRT VPFKIKSRSI EKTASTRLLG MSLEDAMKRY 

        70         80         90        100        110        120 
PLFNFYPGQS IREILSSWER VTYGNGETIA APGFILQGLV EIWYREHLVC VKEKGSFLNG 

       130        140        150        160        170        180 
SMELLGYSTR GTKKARGSVE VLLIDASLVR DNIWYILFSM LRKSCIEIAC RYFELESKLV 

       190        200        210        220        230        240 
EKETMKIKDD GQGHLDLFLS FLNEKLLLNL DDGKEILRRD IEARLIGRGE TIKDSEESMD 

       250        260        270        280        290        300 
YIMYVVSGEI LVLAGESAFV FGKGSVFGYF SLFFDLYSSI KIQAREDSSV LLCSSSVLLK 

       310        320        330        340        350        360 
FGLDEKKFDH SMLLDIDESL HIIDESAEWM RLLPGDMIAQ KGDASKEIFY IGAGSVKSAS 

       370        380        390        400        410        420 
RESSSGTVIG GKECIFGESW NESSIATRIT DVVRIPSLLV DYFLERDKSF FKKYTKRLFE 

       430        440        450        460        470        480 
SGNKANGKIV SIIPVGQYKD IESFSRKLKS AIGASSLLLS RRDVVEILAR RAFDTTEEVR 

       490        500        510        520        530        540 
FMDYLTKMSR RYEIILIYVE NEYSRLLRYL LNFSDVLLAV GTTFADIPEY NVYCRIEFVK 

       550        560        570        580        590        600 
IYEERRASDE RSVKKSKKIN HGPRYLESRK ESFGQYDRVH HVLFPSKTML FCSKDFQRLA 

       610        620        630        640        650        660 
RSLLGKRIGL VLGGGGARGL AHIGVIQALE EEGIPIDCVG GTSMGAFIGA LYAKECNNYH 

       670        680        690        700        710        720 
VFKQAKRFSR KMSNIWILLL DLTYPICSMF SGHAFNRSLH SIFGDGLIQD LWLEYFCITT 

       730        740        750        760        770        780 
NIVSYEEEVH RNGMVWRYVR ASMGLCGYLP PICDNKKLLV DGGYLNNVPA DVMMGMQVEK 

       790        800        810        820        830        840 
IITVDVGTVL ENDHFDYGDT LSGFTILFNK FFGNKKFVTM EEIQYRLAYI STERKMKELE 

       850        860        870        880        890        900 
ANGNIIMLRP DLGKYRTMDF KKFDEIVACG YQSTKNAIAK WKQEGTYDVL FFSLKKQTPK 


RRYSV 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590445 Genomic DNA. Translation: CAD26524.1.
RefSeqNP_597347.1. NM_001041213.1.

3D structure databases

ProteinModelPortalQ8SVN8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU05_0070.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859011.
KEGGecu:ECU05_0070.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU05_0070.

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000113869.
KOK14676.
OMAWNESSIA.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_ENCCU
AccessionPrimary (citable) accession number: Q8SVN8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families