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Q8SVN8

- NTE1_ENCCU

UniProt

Q8SVN8 - NTE1_ENCCU

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei643 – 6431By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 319122cNMP 1Add
    BLAST
    Nucleotide bindingi310 – 428119cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:ECU05_0070
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome V

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU05_0070.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 905905Lysophospholipase NTE1PRO_0000295321Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU05_0070.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SVN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 905884CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini610 – 774165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi641 – 6455GXSXG

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000113869.
    KOiK14676.
    OMAiWNESSIA.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SVN8-1 [UniParc]FASTAAdd to Basket

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    MVSLSLLIAI IVVTGLLAGF RHYGSSRCRT VPFKIKSRSI EKTASTRLLG    50
    MSLEDAMKRY PLFNFYPGQS IREILSSWER VTYGNGETIA APGFILQGLV 100
    EIWYREHLVC VKEKGSFLNG SMELLGYSTR GTKKARGSVE VLLIDASLVR 150
    DNIWYILFSM LRKSCIEIAC RYFELESKLV EKETMKIKDD GQGHLDLFLS 200
    FLNEKLLLNL DDGKEILRRD IEARLIGRGE TIKDSEESMD YIMYVVSGEI 250
    LVLAGESAFV FGKGSVFGYF SLFFDLYSSI KIQAREDSSV LLCSSSVLLK 300
    FGLDEKKFDH SMLLDIDESL HIIDESAEWM RLLPGDMIAQ KGDASKEIFY 350
    IGAGSVKSAS RESSSGTVIG GKECIFGESW NESSIATRIT DVVRIPSLLV 400
    DYFLERDKSF FKKYTKRLFE SGNKANGKIV SIIPVGQYKD IESFSRKLKS 450
    AIGASSLLLS RRDVVEILAR RAFDTTEEVR FMDYLTKMSR RYEIILIYVE 500
    NEYSRLLRYL LNFSDVLLAV GTTFADIPEY NVYCRIEFVK IYEERRASDE 550
    RSVKKSKKIN HGPRYLESRK ESFGQYDRVH HVLFPSKTML FCSKDFQRLA 600
    RSLLGKRIGL VLGGGGARGL AHIGVIQALE EEGIPIDCVG GTSMGAFIGA 650
    LYAKECNNYH VFKQAKRFSR KMSNIWILLL DLTYPICSMF SGHAFNRSLH 700
    SIFGDGLIQD LWLEYFCITT NIVSYEEEVH RNGMVWRYVR ASMGLCGYLP 750
    PICDNKKLLV DGGYLNNVPA DVMMGMQVEK IITVDVGTVL ENDHFDYGDT 800
    LSGFTILFNK FFGNKKFVTM EEIQYRLAYI STERKMKELE ANGNIIMLRP 850
    DLGKYRTMDF KKFDEIVACG YQSTKNAIAK WKQEGTYDVL FFSLKKQTPK 900
    RRYSV 905
    Length:905
    Mass (Da):103,088
    Last modified:June 1, 2002 - v1
    Checksum:i94B9D7775EA8E92C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590445 Genomic DNA. Translation: CAD26524.1.
    RefSeqiNP_597347.1. NM_001041213.1.

    Genome annotation databases

    GeneIDi859011.
    KEGGiecu:ECU05_0070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590445 Genomic DNA. Translation: CAD26524.1 .
    RefSeqi NP_597347.1. NM_001041213.1.

    3D structure databases

    ProteinModelPortali Q8SVN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU05_0070.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859011.
    KEGGi ecu:ECU05_0070.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU05_0070.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000113869.
    KOi K14676.
    OMAi WNESSIA.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.

    Entry informationi

    Entry nameiNTE1_ENCCU
    AccessioniPrimary (citable) accession number: Q8SVN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3