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Q8SVM5

- PMM_ENCCU

UniProt

Q8SVM5 - PMM_ENCCU

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Protein

Phosphomannomutase

Gene

SEC53

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121NucleophileBy similarity
Active sitei14 – 141Proton donor/acceptorSequence Analysis
Binding sitei21 – 211SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei134 – 1341SubstrateBy similarity
Binding sitei141 – 1411SubstrateBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Binding sitei181 – 1811SubstrateBy similarity

GO - Molecular functioni

  1. phosphomannomutase activity Source: UniProtKB-EC

GO - Biological processi

  1. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
  2. mannose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
Name:SEC53
Ordered Locus Names:ECU05_0260
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0260.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256PhosphomannomutasePRO_0000382908Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi6035.ECU05_0260.

Structurei

3D structure databases

ProteinModelPortaliQ8SVM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiCOG0561.
HOGENOMiHOG000181843.
InParanoidiQ8SVM5.
KOiK17497.
OMAiTYCLQHV.
OrthoDBiEOG7X3R31.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SVM5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARDEKTIFL FDVDGTLSES RAKMPEKMGK MLESLRRKVR IGFVGGSDLA
60 70 80 90 100
KQKEQVGDNI LEIFDYGFPE NGVSFYKNGT LESQEKIIDV LGEEFYKEFA
110 120 130 140 150
NFVLRYLSDI DLPIKRGNFI EYRNSMINIS PIGRNCSREE RMKFFELDKK
160 170 180 190 200
EKFREKMVTA MRDRFKDSCL VFSIGGQISI DCFPKGWDKT YCLRHIKKEG
210 220 230 240 250
VENVYFFGDM TMEGGNDYEI YNHKDVHGIS VGNPDDTYRK VDQALKKIGL

GGLEEN
Length:256
Mass (Da):29,616
Last modified:June 1, 2002 - v1
Checksum:iDBDEFE2929D73D10
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590445 Genomic DNA. Translation: CAD26542.1.
RefSeqiNP_597365.1. NM_001041231.1.

Genome annotation databases

GeneIDi859029.
KEGGiecu:ECU05_0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590445 Genomic DNA. Translation: CAD26542.1 .
RefSeqi NP_597365.1. NM_001041231.1.

3D structure databases

ProteinModelPortali Q8SVM5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU05_0260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859029.
KEGGi ecu:ECU05_0260.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU05_0260.

Phylogenomic databases

eggNOGi COG0561.
HOGENOMi HOG000181843.
InParanoidi Q8SVM5.
KOi K17497.
OMAi TYCLQHV.
OrthoDBi EOG7X3R31.

Enzyme and pathway databases

UniPathwayi UPA00126 ; UER00424 .

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view ]
PANTHERi PTHR10466. PTHR10466. 1 hit.
Pfami PF03332. PMM. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPMM_ENCCU
AccessioniPrimary (citable) accession number: Q8SVM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3