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Q8SV03

- FCP1_ENCCU

UniProt

Q8SV03 - FCP1_ENCCU

Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

FCP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium or manganese or cobalt.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661By similarity
    Active sitei68 – 681By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Cobalt, Magnesium, Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase (EC:3.1.3.16)
    Alternative name(s):
    CTD phosphatase FCP1
    Gene namesi
    Name:FCP1
    Ordered Locus Names:ECU07_0890
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome VII

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU07_0890.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411RNA polymerase II subunit A C-terminal domain phosphatasePRO_0000212566Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    STRINGi6035.ECU07_0890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SV03.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 212157FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST
    Domaini309 – 39385BRCTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BRCT domain.PROSITE-ProRule annotation
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5190.
    HOGENOMiHOG000112561.
    KOiK15732.
    OrthoDBiEOG7TXKSN.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR011947. FCP1_euk.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    SM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52113. SSF52113. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02250. FCP1_euk. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS50969. FCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SV03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGCNHPIRL GTLCGVCGME IQEESHLFCA LYNTDNVKIT HEEAVAIHKE    50
    KMEALEMQMK LILVLDLDQT VLHTTYGTSS LEGTVKFVID RCRYCVKLRP 100
    NLDYMLRRIS KLYEIHVYTM GTRAYAERIV EIIDPSGKYF DDRIITRDEN 150
    QGVLVKRLSR LFPHDHRNIV ILDDRPDVWD YCENLVLIRP FWYFNRVDIN 200
    DPLRLKRKIE KEAGENKALE EFVSKRKKIE DIRNPEIASR LDDMVLESSC 250
    GSEGVEDDSR STEEKEVSEV QSVASGDSEL LKVAGFLRKV HRKYFASKQR 300
    NVKRILRKIR RRVFGGDRFF VAEIANRAWL VKTIEMYGGI VGIPESGVDF 350
    VVSSCEREAE YLAQKFECLA VSPKWIADCV YSLKRVEYGK YVVCDHRTKD 400
    EYEEELERLF T 411
    Length:411
    Mass (Da):47,791
    Last modified:June 1, 2002 - v1
    Checksum:i030806FD1C2C6221
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590447 Genomic DNA. Translation: CAD25621.1.
    RefSeqiNP_586017.1. NM_001041639.1.

    Genome annotation databases

    GeneIDi859447.
    KEGGiecu:ECU07_0890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590447 Genomic DNA. Translation: CAD25621.1 .
    RefSeqi NP_586017.1. NM_001041639.1.

    3D structure databases

    ProteinModelPortali Q8SV03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU07_0890.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859447.
    KEGGi ecu:ECU07_0890.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU07_0890.

    Phylogenomic databases

    eggNOGi COG5190.
    HOGENOMi HOG000112561.
    KOi K15732.
    OrthoDBi EOG7TXKSN.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR011947. FCP1_euk.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52113. SSF52113. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02250. FCP1_euk. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "An Encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1."
      Hausmann S., Schwer B., Shuman S.
      Biochemistry 43:7111-7120(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.

    Entry informationi

    Entry nameiFCP1_ENCCU
    AccessioniPrimary (citable) accession number: Q8SV03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3