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Q8SV03

- FCP1_ENCCU

UniProt

Q8SV03 - FCP1_ENCCU

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Protein
RNA polymerase II subunit A C-terminal domain phosphatase
Gene
FCP1, ECU07_0890
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Magnesium or manganese or cobalt By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661 By similarity
Active sitei68 – 681 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Cobalt, Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase (EC:3.1.3.16)
Alternative name(s):
CTD phosphatase FCP1
Gene namesi
Name:FCP1
Ordered Locus Names:ECU07_0890
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU07_0890.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411RNA polymerase II subunit A C-terminal domain phosphatase
PRO_0000212566Add
BLAST

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi6035.ECU07_0890.

Structurei

3D structure databases

ProteinModelPortaliQ8SV03.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 212157FCP1 homology
Add
BLAST
Domaini309 – 39385BRCT
Add
BLAST

Sequence similaritiesi

Contains 1 BRCT domain.

Phylogenomic databases

eggNOGiCOG5190.
HOGENOMiHOG000112561.
KOiK15732.
OrthoDBiEOG7TXKSN.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
3.40.50.10190. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR011947. FCP1_euk.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 1 hit.
SM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02250. FCP1_euk. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS50969. FCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SV03-1 [UniParc]FASTAAdd to Basket

« Hide

MGGCNHPIRL GTLCGVCGME IQEESHLFCA LYNTDNVKIT HEEAVAIHKE    50
KMEALEMQMK LILVLDLDQT VLHTTYGTSS LEGTVKFVID RCRYCVKLRP 100
NLDYMLRRIS KLYEIHVYTM GTRAYAERIV EIIDPSGKYF DDRIITRDEN 150
QGVLVKRLSR LFPHDHRNIV ILDDRPDVWD YCENLVLIRP FWYFNRVDIN 200
DPLRLKRKIE KEAGENKALE EFVSKRKKIE DIRNPEIASR LDDMVLESSC 250
GSEGVEDDSR STEEKEVSEV QSVASGDSEL LKVAGFLRKV HRKYFASKQR 300
NVKRILRKIR RRVFGGDRFF VAEIANRAWL VKTIEMYGGI VGIPESGVDF 350
VVSSCEREAE YLAQKFECLA VSPKWIADCV YSLKRVEYGK YVVCDHRTKD 400
EYEEELERLF T 411
Length:411
Mass (Da):47,791
Last modified:June 1, 2002 - v1
Checksum:i030806FD1C2C6221
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590447 Genomic DNA. Translation: CAD25621.1.
RefSeqiNP_586017.1. NM_001041639.1.

Genome annotation databases

GeneIDi859447.
KEGGiecu:ECU07_0890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590447 Genomic DNA. Translation: CAD25621.1 .
RefSeqi NP_586017.1. NM_001041639.1.

3D structure databases

ProteinModelPortali Q8SV03.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU07_0890.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859447.
KEGGi ecu:ECU07_0890.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU07_0890.

Phylogenomic databases

eggNOGi COG5190.
HOGENOMi HOG000112561.
KOi K15732.
OrthoDBi EOG7TXKSN.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
3.40.50.10190. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR011947. FCP1_euk.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
[Graphical view ]
SMARTi SM00292. BRCT. 1 hit.
SM00577. CPDc. 1 hit.
[Graphical view ]
SUPFAMi SSF52113. SSF52113. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02250. FCP1_euk. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS50969. FCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "An Encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1."
    Hausmann S., Schwer B., Shuman S.
    Biochemistry 43:7111-7120(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.

Entry informationi

Entry nameiFCP1_ENCCU
AccessioniPrimary (citable) accession number: Q8SV03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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