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Q8SV03 (FCP1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RNA polymerase II subunit A C-terminal domain phosphatase

EC=3.1.3.16
Alternative name(s):
CTD phosphatase FCP1
Gene names
Name:FCP1
Ordered Locus Names:ECU07_0890
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. Ref.2

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Magnesium or manganese or cobalt By similarity.

Subunit structure

Monomer. Ref.2

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 BRCT domain.

Contains 1 FCP1 homology domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandCobalt
Magnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411RNA polymerase II subunit A C-terminal domain phosphatase
PRO_0000212566

Regions

Domain56 – 212157FCP1 homology
Domain309 – 39385BRCT

Sites

Active site661 By similarity
Active site681 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SV03 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 030806FD1C2C6221

FASTA41147,791
        10         20         30         40         50         60 
MGGCNHPIRL GTLCGVCGME IQEESHLFCA LYNTDNVKIT HEEAVAIHKE KMEALEMQMK 

        70         80         90        100        110        120 
LILVLDLDQT VLHTTYGTSS LEGTVKFVID RCRYCVKLRP NLDYMLRRIS KLYEIHVYTM 

       130        140        150        160        170        180 
GTRAYAERIV EIIDPSGKYF DDRIITRDEN QGVLVKRLSR LFPHDHRNIV ILDDRPDVWD 

       190        200        210        220        230        240 
YCENLVLIRP FWYFNRVDIN DPLRLKRKIE KEAGENKALE EFVSKRKKIE DIRNPEIASR 

       250        260        270        280        290        300 
LDDMVLESSC GSEGVEDDSR STEEKEVSEV QSVASGDSEL LKVAGFLRKV HRKYFASKQR 

       310        320        330        340        350        360 
NVKRILRKIR RRVFGGDRFF VAEIANRAWL VKTIEMYGGI VGIPESGVDF VVSSCEREAE 

       370        380        390        400        410 
YLAQKFECLA VSPKWIADCV YSLKRVEYGK YVVCDHRTKD EYEEELERLF T 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"An Encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1."
Hausmann S., Schwer B., Shuman S.
Biochemistry 43:7111-7120(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590447 Genomic DNA. Translation: CAD25621.1.
RefSeqNP_586017.1. NM_001041639.1.

3D structure databases

ProteinModelPortalQ8SV03.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU07_0890.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859447.
KEGGecu:ECU07_0890.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU07_0890.

Phylogenomic databases

eggNOGCOG5190.
HOGENOMHOG000112561.
KOK15732.
OrthoDBEOG7TXKSN.

Family and domain databases

Gene3D3.40.50.1000. 2 hits.
3.40.50.10190. 1 hit.
InterProIPR001357. BRCT_dom.
IPR011947. FCP1_euk.
IPR023214. HAD-like_dom.
IPR004274. NIF.
[Graphical view]
PfamPF03031. NIF. 1 hit.
[Graphical view]
SMARTSM00292. BRCT. 1 hit.
SM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMSSF52113. SSF52113. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02250. FCP1_euk. 1 hit.
PROSITEPS50172. BRCT. 1 hit.
PS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFCP1_ENCCU
AccessionPrimary (citable) accession number: Q8SV03
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families