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Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

FCP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity, Co2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66By similarity1
Active sitei68By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandCobalt, Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II subunit A C-terminal domain phosphatase (EC:3.1.3.16)
Alternative name(s):
CTD phosphatase FCP1
Gene namesi
Name:FCP1
Ordered Locus Names:ECU07_0890
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU07_0890

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125661 – 411RNA polymerase II subunit A C-terminal domain phosphataseAdd BLAST411

Proteomic databases

PRIDEiQ8SV03

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

STRINGi284813.NP_586017.1

Structurei

3D structure databases

ProteinModelPortaliQ8SV03
SMRiQ8SV03
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 212FCP1 homologyPROSITE-ProRule annotationAdd BLAST157
Domaini309 – 393BRCTPROSITE-ProRule annotationAdd BLAST85

Phylogenomic databases

eggNOGiKOG0323 Eukaryota
COG5190 LUCA
HOGENOMiHOG000112561
InParanoidiQ8SV03
KOiK15732
OrthoDBiEOG092C3D5H

Family and domain databases

Gene3Di3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR004274 FCP1_dom
IPR011947 FCP1_euk
IPR036412 HAD-like_sf
PfamiView protein in Pfam
PF16589 BRCT_2, 1 hit
PF03031 NIF, 1 hit
SMARTiView protein in SMART
SM00577 CPDc, 1 hit
SUPFAMiSSF52113 SSF52113, 1 hit
SSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02250 FCP1_euk, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit
PS50969 FCP1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SV03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCNHPIRL GTLCGVCGME IQEESHLFCA LYNTDNVKIT HEEAVAIHKE
60 70 80 90 100
KMEALEMQMK LILVLDLDQT VLHTTYGTSS LEGTVKFVID RCRYCVKLRP
110 120 130 140 150
NLDYMLRRIS KLYEIHVYTM GTRAYAERIV EIIDPSGKYF DDRIITRDEN
160 170 180 190 200
QGVLVKRLSR LFPHDHRNIV ILDDRPDVWD YCENLVLIRP FWYFNRVDIN
210 220 230 240 250
DPLRLKRKIE KEAGENKALE EFVSKRKKIE DIRNPEIASR LDDMVLESSC
260 270 280 290 300
GSEGVEDDSR STEEKEVSEV QSVASGDSEL LKVAGFLRKV HRKYFASKQR
310 320 330 340 350
NVKRILRKIR RRVFGGDRFF VAEIANRAWL VKTIEMYGGI VGIPESGVDF
360 370 380 390 400
VVSSCEREAE YLAQKFECLA VSPKWIADCV YSLKRVEYGK YVVCDHRTKD
410
EYEEELERLF T
Length:411
Mass (Da):47,791
Last modified:June 1, 2002 - v1
Checksum:i030806FD1C2C6221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590447 Genomic DNA Translation: CAD25621.1
RefSeqiNP_586017.1, NM_001041639.1

Genome annotation databases

EnsemblFungiiCAD25621; CAD25621; CAD25621
GeneIDi859447
KEGGiecu:ECU07_0890

Similar proteinsi

Entry informationi

Entry nameiFCP1_ENCCU
AccessioniPrimary (citable) accession number: Q8SV03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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