Reviewed, UniProtKB/Swiss-Prot Q8ST87 (ABCCA_DICDI)

Names and origin

Protein names

Recommended name:
    ABC transporter C family member 10
Alternative name(s):
    ABC transporter ABCC.10

Gene names

Name:	abcC10
ORF Names:	DDB_G0280977

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	1334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification] Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1334	1334	ABC transporter C family member 10		PRO_0000363855
Regions
	Transmembrane	106 – 126	21	Potential
	Transmembrane	147 – 167	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	247 – 267	21	Potential
	Transmembrane	333 – 353	21	Potential
	Transmembrane	370 – 390	21	Potential
	Transmembrane	718 – 738	21	Potential
	Transmembrane	776 – 796	21	Potential
	Transmembrane	843 – 863	21	Potential
	Transmembrane	865 – 885	21	Potential
	Transmembrane	958 – 978	21	Potential
	Transmembrane	984 – 1004	21	Potential
	Domain	105 – 391	287	ABC transmembrane type-1 1
	Domain	423 – 647	225	ABC transporter 1
	Domain	726 – 1016	291	ABC transmembrane type-1 2
	Domain	1053 – 1287	235	ABC transporter 2
	Nucleotide binding	459 – 466	8	ATP Potential
	Nucleotide binding	1087 – 1094	8	ATP Potential
	Compositional bias	12 – 21	10	Poly-Lys
	Compositional bias	1329 – 1333	5	Poly-Pro

Sequences

	Sequence		Length	Mass (Da)
	Q8ST87-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B29253642F2B32E8	FASTA	1,334	149,289
	10 20 30 40 50 60 MKEIELDRPE EKKKKVKKEK KIGYGGKKSP EENSNFLSNL TFSWADGFVI HCFRNVLQLS 70 80 90 100 110 120 HLWDLASYDK SEYLAKKIAK SWEIEIQKPK PSYLRAGFRA FGKLQLLSIF LYAISVGIQF 130 140 150 160 170 180 VGPEILGRMV TFVVESKLGT STEDPNMGYY YALIMFGTAM IGSFCTYHAN RISFRTGDRL 190 200 210 220 230 240 RSIIVLDVYK KAIKLSNSAR SDTSPGQIVN LMSNDAQRMV EVFGMFNNGA LALPQIIICL 250 260 270 280 290 300 ALLYKKIGWP TFVGLGLMLA AIPFNGMAAK KLTETRKYLV SLSDSRVKAT NEILQAIKII 310 320 330 340 350 360 KLYAWEDSFA KKVIEHRNNE IKLLFSYSRY RTILIVIISA LPTAAAILVI SSYYGHEKSL 370 380 390 400 410 420 DASRIFSALS YLNLLRLPLG FLPIIIALGI QMQIAGKRVT DFLLLPEMKD IQQIDNPSLP 430 440 450 460 470 480 NGVYMKNSTT TWNKLKEDSF GLKNINFEAT GTSLTMVVGS VGSGKSTLVQ AMLGELEIID 490 500 510 520 530 540 GEIGIKGSIA YVPQQAWIIN ATLKENIIFG KELDEERYQK VLEVCALKRD IELFPQGDSV 550 560 570 580 590 600 EIGERGINLS GGQKQRVSIA RAVYSDADVY ILDDPLSAVD SHVGKHLFHK CFKGILSSKT 610 620 630 640 650 660 VILVANQLNY LPFADNTVVL KSGEIVERGT YYELINSKLE FSSILEKYGV DENVISKKDD 670 680 690 700 710 720 IDEDEDEDQD TIEKVEIDLN KDEKSQPKSK SSNTDGTLIS EEESEQGAVA GKVYWKYVTA 730 740 750 760 770 780 GGGLLFLVSM IFFLLETGSK TFSDWWLSHW QTESSERMES ILLGEEPTGL TDDQNLGIYI 790 800 810 820 830 840 GLGMAAVFIS VCKNFIYYEY SVYASRAIHH ELFNALLKKP MYFFDQTPIG RIINRFTRDL 850 860 870 880 890 900 DGIDNLIATS ISTFLTLMLT VIATIILVSI IVPFLLIPLA PISIIFFFLQ YFYRYTSRGL 910 920 930 940 950 960 QRIEAITRSP IFNHFSETLN GVVSIRAYKK QQENILINQK RLDDNNNCYL TLQAMNRWLG 970 980 990 1000 1010 1020 LRLDFLANLI TFFACIFITI DKDTISPANV GLALGYALSL TGNLNYAALQ AADTETKMNS 1030 1040 1050 1060 1070 1080 VERISQYIRG AVEAPQIIDD CRPSPDWPIN GSIKFDNLVM RYREGLDPVL KGITCEIKAK 1090 1100 1110 1120 1130 1140 EKIGIVGRTG AGKSSIVLAL FRLIEASEGS ISIDGENIAK FGLKDLRRNL AIIPQDPVLF 1150 1160 1170 1180 1190 1200 SGTLRENLDP FNERSEEDLF STIEDIQMSA VVKSLEGGLD SKVTENGENF SVGQRQLIVL 1210 1220 1230 1240 1250 1260 ARALLRKPKI LVLDEATASV DGQSDSLIQA TIRNKFSNCT ILTIAHRLNT IMDSDRIMVL 1270 1280 1290 1300 1310 1320 DAGKISEFDE PWTLLQNQNG LLTWLVDETG PQNAIYLRKL AEAKKNGIDI NEIMPIDNET 1330 TPKDNINTPP PPPQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF474342 Genomic DNA. Translation: AAL85713.1. AAFI02000040 Genomic DNA. Translation: EAL66785.1.
RefSeq	XP_640934.1.
3D structure databases
HSSP	HSSP built from PDB template 2CBZ based on UniProtKB P33527.
ModBase	Search...
Genome annotation databases
GeneID	3391870.
GenomeReviews	Gene locus abcC10 in contig CM000152_GR.
KEGG	ddi:DDB_0215367.
Organism-specific databases
dictyBase	DDB_G0280977. abcC10.
Phylogenomic databases
HOGENOM	HBG758042.
InParanoid	Q8ST87.
OMA	NERSEED.
Family and domain databases
InterPro	IPR011527. ABC_TM_1. IPR001140. ABC_TM_transpt. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCCA_DICDI

Accession

Primary (citable) accession number: Q8ST87
Secondary accession number(s): Q54U42

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	June 1, 2002
Last modified:	December 15, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)