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Protein

Polycomb protein PHO

Gene

pho

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Polycomb group (PcG) protein that binds to the 5'-CNGCCATNNNNG-3' sequence found in the regulatory regions of many genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Probably targets the Esc/E(z) complex to DNA. Necessary but not sufficient to recruit a functional PcG repressive complex that represses target genes, suggesting that the recruitment of the distinct PRC1 complex is also required to allow a subsequent repression.2 Publications
Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri357 – 38125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43825C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46825C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: FlyBase
  • chromatin DNA binding Source: FlyBase
  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II distal enhancer sequence-specific DNA binding Source: FlyBase
  • sequence-specific DNA binding Source: FlyBase
  • transcription factor activity, sequence-specific DNA binding Source: FlyBase

GO - Biological processi

  • chromatin-mediated maintenance of transcription Source: UniProtKB
  • chromatin remodeling Source: FlyBase
  • chromatin silencing Source: UniProtKB
  • dendrite morphogenesis Source: FlyBase
  • DNA recombination Source: UniProtKB-KW
  • DNA repair Source: UniProtKB-KW
  • DNA topological change Source: FlyBase
  • gene silencing Source: FlyBase
  • negative regulation of gene expression Source: FlyBase
  • negative regulation of transcription, DNA-templated Source: FlyBase
  • regulation of transcription, DNA-templated Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ8ST83.

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb protein PHO
Alternative name(s):
Protein pleiohomeotic
Transcription factor YY1 homolog
Gene namesi
Name:pho
ORF Names:CG17743
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 4

Organism-specific databases

FlyBaseiFBgn0002521. pho.

Subcellular locationi

GO - Cellular componenti

  • Ino80 complex Source: FlyBase
  • nuclear chromatin Source: UniProtKB
  • nucleus Source: FlyBase
  • PcG protein complex Source: FlyBase
  • polytene chromosome Source: FlyBase
  • polytene chromosome band Source: FlyBase
  • polytene chromosome puff Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Polycomb protein PHOPRO_0000047017Add
BLAST

Proteomic databases

PaxDbiQ8ST83.
PRIDEiQ8ST83.

Expressioni

Developmental stagei

Maternally and zygotically expressed.

Gene expression databases

BgeeiQ8ST83.
GenevisibleiQ8ST83. DM.

Interactioni

Subunit structurei

Component of the Esc/E(z) complex, composed of Esc, E(z), Su(z)12, Rpd3 and Caf1. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Component of the chromatin remodeling Ino80 complex. Interacts with Sfmbt to form a pho-repressive complex (PhoRC).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ino80Q9VDY14EBI-125201,EBI-3414232
SfmbtQ9VK336EBI-125201,EBI-117801

Protein-protein interaction databases

BioGridi68646. 18 interactions.
DIPiDIP-20923N.
IntActiQ8ST83. 9 interactions.
MINTiMINT-1630194.
STRINGi7227.FBpp0088268.

Structurei

Secondary structure

1
520
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi147 – 15711Combined sources
Beta strandi160 – 16910Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5EX-ray1.95E/F/G/H145-172[»]
4C5GX-ray2.10B145-172[»]
4C5HX-ray3.20B116-246[»]
ProteinModelPortaliQ8ST83.
SMRiQ8ST83. Positions 145-170, 357-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri357 – 38125C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43825C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri444 – 46825C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
InParanoidiQ8ST83.
KOiK09201.
OMAiWASGISD.
OrthoDBiEOG769ZJD.
PhylomeDBiQ8ST83.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ST83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYERFGIIL QSEQYDEDIG NTKVNQKMNE GNHYDLHRKN AFDRIIHSES
60 70 80 90 100
KKGDNVINYN IHENDKIKAA DNIFSSKLKM NPNMSYEMNI NCFKNIGYGE
110 120 130 140 150
NQETSKVLTN SLSNNDINTE ESGVVDKNSP FLTLGTTILN SNGKSRRWEQ
160 170 180 190 200
KLVHIKTMEG EFSVTMWASG ISDDEYSGSD QIVGASDLLK GKEEFGIDGF
210 220 230 240 250
TSQQNKEYQK MESKFTNAQT LEMPHPISSV QIMDHLIKER GNLSQENNIS
260 270 280 290 300
ERILSKTTLS FEEPILLPDS SSIELVNETA AMTINNHRTL SNHTGNTGDL
310 320 330 340 350
HALPSSVPFR IGLHEGQVND CLSTISQSTH QDNTDSTGCG EMNLSEVTVS
360 370 380 390 400
YTNDKKIACP HKGCNKHFRD SSAMRKHLHT HGPRVHVCAE CGKAFVESSK
410 420 430 440 450
LKRHQLVHTG EKPFQCTFEG CGKRFSLDFN LRTHVRIHTG DRPFVCPFDA
460 470 480 490 500
CNKKFAQSTN LKSHILTHAK AKRNTSISGK SGCSNAESNS QSEDTSANYV
510 520
KVELQDSVTE NHVPFVVYAD
Length:520
Mass (Da):58,224
Last modified:March 28, 2003 - v2
Checksum:i95E729571C5194E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034212 mRNA. Translation: AAC39123.1.
AE014135 Genomic DNA. Translation: AAF59378.2.
AE014135 Genomic DNA. Translation: AAN06584.1.
AY071143 mRNA. Translation: AAL48765.1.
AF433865 Genomic DNA. Translation: AAM18016.1.
AF433866 Genomic DNA. Translation: AAM18017.1.
AF433867 Genomic DNA. Translation: AAM18018.1.
AF433868 Genomic DNA. Translation: AAM18019.1.
AF433869 Genomic DNA. Translation: AAM18020.1.
AF433870 Genomic DNA. Translation: AAM18021.1.
AF433871 Genomic DNA. Translation: AAM18022.1.
AF433872 Genomic DNA. Translation: AAM18023.1.
AF433873 Genomic DNA. Translation: AAM18024.1.
AF433874 Genomic DNA. Translation: AAM18025.1.
AY312758 Genomic DNA. Translation: AAQ67572.1.
AY312759 Genomic DNA. Translation: AAQ67573.1.
AY312760 Genomic DNA. Translation: AAQ67574.1.
AY312761 Genomic DNA. Translation: AAQ67575.1.
AY312762 Genomic DNA. Translation: AAQ67576.1.
AY312763 Genomic DNA. Translation: AAQ67577.1.
AY312764 Genomic DNA. Translation: AAQ67578.1.
AY312765 Genomic DNA. Translation: AAQ67579.1.
AY312766 Genomic DNA. Translation: AAQ67580.1.
AY312767 Genomic DNA. Translation: AAQ67581.1.
AY312768 Genomic DNA. Translation: AAQ67582.1.
AY312769 Genomic DNA. Translation: AAQ67583.1.
AY312770 Genomic DNA. Translation: AAQ67584.1.
AY312771 Genomic DNA. Translation: AAQ67585.1.
AY312772 Genomic DNA. Translation: AAQ67586.1.
AY312773 Genomic DNA. Translation: AAQ67587.1.
AY312774 Genomic DNA. Translation: AAQ67588.1.
AY312775 Genomic DNA. Translation: AAQ67589.1.
AY312776 Genomic DNA. Translation: AAQ67590.1.
AY312777 Genomic DNA. Translation: AAQ67591.1.
AY312778 Genomic DNA. Translation: AAQ67592.1.
AY312779 Genomic DNA. Translation: AAQ67593.1.
AY312780 Genomic DNA. Translation: AAQ67594.1.
AY312781 Genomic DNA. Translation: AAQ67595.1.
RefSeqiNP_524630.1. NM_079891.3.
NP_726651.1. NM_166827.2.
UniGeneiDm.1406.

Genome annotation databases

EnsemblMetazoaiFBtr0089204; FBpp0088268; FBgn0002521.
FBtr0089205; FBpp0088269; FBgn0002521.
GeneIDi43819.
KEGGidme:Dmel_CG17743.
UCSCiCG17743-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF034212 mRNA. Translation: AAC39123.1.
AE014135 Genomic DNA. Translation: AAF59378.2.
AE014135 Genomic DNA. Translation: AAN06584.1.
AY071143 mRNA. Translation: AAL48765.1.
AF433865 Genomic DNA. Translation: AAM18016.1.
AF433866 Genomic DNA. Translation: AAM18017.1.
AF433867 Genomic DNA. Translation: AAM18018.1.
AF433868 Genomic DNA. Translation: AAM18019.1.
AF433869 Genomic DNA. Translation: AAM18020.1.
AF433870 Genomic DNA. Translation: AAM18021.1.
AF433871 Genomic DNA. Translation: AAM18022.1.
AF433872 Genomic DNA. Translation: AAM18023.1.
AF433873 Genomic DNA. Translation: AAM18024.1.
AF433874 Genomic DNA. Translation: AAM18025.1.
AY312758 Genomic DNA. Translation: AAQ67572.1.
AY312759 Genomic DNA. Translation: AAQ67573.1.
AY312760 Genomic DNA. Translation: AAQ67574.1.
AY312761 Genomic DNA. Translation: AAQ67575.1.
AY312762 Genomic DNA. Translation: AAQ67576.1.
AY312763 Genomic DNA. Translation: AAQ67577.1.
AY312764 Genomic DNA. Translation: AAQ67578.1.
AY312765 Genomic DNA. Translation: AAQ67579.1.
AY312766 Genomic DNA. Translation: AAQ67580.1.
AY312767 Genomic DNA. Translation: AAQ67581.1.
AY312768 Genomic DNA. Translation: AAQ67582.1.
AY312769 Genomic DNA. Translation: AAQ67583.1.
AY312770 Genomic DNA. Translation: AAQ67584.1.
AY312771 Genomic DNA. Translation: AAQ67585.1.
AY312772 Genomic DNA. Translation: AAQ67586.1.
AY312773 Genomic DNA. Translation: AAQ67587.1.
AY312774 Genomic DNA. Translation: AAQ67588.1.
AY312775 Genomic DNA. Translation: AAQ67589.1.
AY312776 Genomic DNA. Translation: AAQ67590.1.
AY312777 Genomic DNA. Translation: AAQ67591.1.
AY312778 Genomic DNA. Translation: AAQ67592.1.
AY312779 Genomic DNA. Translation: AAQ67593.1.
AY312780 Genomic DNA. Translation: AAQ67594.1.
AY312781 Genomic DNA. Translation: AAQ67595.1.
RefSeqiNP_524630.1. NM_079891.3.
NP_726651.1. NM_166827.2.
UniGeneiDm.1406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C5EX-ray1.95E/F/G/H145-172[»]
4C5GX-ray2.10B145-172[»]
4C5HX-ray3.20B116-246[»]
ProteinModelPortaliQ8ST83.
SMRiQ8ST83. Positions 145-170, 357-469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68646. 18 interactions.
DIPiDIP-20923N.
IntActiQ8ST83. 9 interactions.
MINTiMINT-1630194.
STRINGi7227.FBpp0088268.

Proteomic databases

PaxDbiQ8ST83.
PRIDEiQ8ST83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0089204; FBpp0088268; FBgn0002521.
FBtr0089205; FBpp0088269; FBgn0002521.
GeneIDi43819.
KEGGidme:Dmel_CG17743.
UCSCiCG17743-RA. d. melanogaster.

Organism-specific databases

CTDi334003.
FlyBaseiFBgn0002521. pho.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
InParanoidiQ8ST83.
KOiK09201.
OMAiWASGISD.
OrthoDBiEOG769ZJD.
PhylomeDBiQ8ST83.

Enzyme and pathway databases

SignaLinkiQ8ST83.

Miscellaneous databases

GenomeRNAii43819.
NextBioi836040.
PROiQ8ST83.

Gene expression databases

BgeeiQ8ST83.
GenevisibleiQ8ST83. DM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1."
    Brown J.L., Mucci D., Whiteley M., Dirksen M.-L., Kassis J.A.
    Mol. Cell 1:1057-1064(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING ACTIVITY.
    Tissue: Embryo.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "Nucleotide variation along the Drosophila melanogaster fourth chromosome."
    Wang W., Thornton K., Berry A., Long M.
    Science 295:134-137(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-373.
    Strain: 253.27, 253.30, Closs10, Closs19, North7.13, Rio, South1.10, Y10, ZH56 and ZW30.
  6. "Recombination, dominance and selection on amino acid polymorphism in the Drosophila genome: contrasting patterns on the X and fourth chromosomes."
    Sheldahl L.A., Weinreich D.M., Rand D.M.
    Genetics 165:1195-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-334.
    Strain: Crete24, Crete26, Crete30, Crete31, Crete35, Crete40, Crete42, Crete43, Crete44, Crete8, FTF1, FTF105, FTF14, FTF2, FTF20, FTF23, FTF26, FTF28, FTF5, FTF6, Zim11, Zim2, Zim30 and Zim53.
  7. "The DNA-binding Polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene."
    Fritsch C., Brown J.L., Kassis J.A., Mueller J.
    Development 126:3905-3913(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Recruitment of components of Polycomb group chromatin complexes in Drosophila."
    Poux S., McCabe D., Pirrotta V.
    Development 128:75-85(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF INTERACTION WITH THE PRC1 POLYCOMB COMPLEX.
  9. "Establishment of Polycomb silencing requires a transient interaction between PC and ESC."
    Poux S., Melfi R., Pirrotta V.
    Genes Dev. 15:2509-2514(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH RPD3; ESC AND E(Z), TRANSIENT INTERACTION WITH THE PRC1 COMPLEX.
  10. "A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities."
    Klymenko T., Papp B., Fischle W., Koecher T., Schelder M., Fritsch C., Wild B., Wilm M., Mueller J.
    Genes Dev. 20:1110-1122(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE INO80 COMPLEX, INTERACTION WITH SFMBT.
    Tissue: Embryo.

Entry informationi

Entry nameiPHO_DROME
AccessioniPrimary (citable) accession number: Q8ST83
Secondary accession number(s): A4V138
, O76247, Q6W466, Q6W467, Q6W470, Q6W480, Q6W485, Q9V4A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: March 28, 2003
Last modified: May 11, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.