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Q8SSM8

- ALF_ENCCU

UniProt

Q8SSM8 - ALF_ENCCU

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Protein

Fructose-bisphosphate aldolase

Gene

ECU01_0240

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501SubstrateBy similarity
Binding sitei138 – 1381SubstrateBy similarity
Active sitei179 – 1791Proton acceptorBy similarity
Active sitei221 – 2211Schiff-base intermediate with dihydroxyacetone-PBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase (EC:4.1.2.13)
Gene namesi
Ordered Locus Names:ECU01_0240
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Fructose-bisphosphate aldolasePRO_0000381751Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU01_0240.

Structurei

Secondary structure

1
338
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1815
Helixi19 – 213
Beta strandi23 – 275
Helixi31 – 4010
Helixi47 – 5812
Helixi63 – 653
Beta strandi67 – 726
Helixi74 – 785
Helixi87 – 937
Beta strandi97 – 1015
Beta strandi106 – 1094
Turni110 – 1123
Beta strandi113 – 1164
Helixi119 – 1213
Helixi122 – 1265
Helixi129 – 1313
Beta strandi136 – 1438
Helixi152 – 17120
Beta strandi175 – 1828
Beta strandi184 – 1863
Helixi190 – 21021
Helixi215 – 2173
Beta strandi219 – 2224
Helixi237 – 25115
Beta strandi258 – 2614
Helixi268 – 28013
Beta strandi286 – 2949
Helixi295 – 30511
Helixi309 – 3113
Helixi312 – 33019

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MBDX-ray2.00A1-338[»]
3MBFX-ray2.37A1-338[»]
3QRHX-ray2.00A1-338[»]
ProteinModelPortaliQ8SSM8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8SSM8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000220876.
InParanoidiQ8SSM8.
KOiK01623.
OMAiDMEHCQY.
OrthoDBiEOG7M0P2G.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SSM8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMDCDHLLRL GMTAKKILEN GKGILAADET PKTLGRRFEK LGITNTEENR
60 70 80 90 100
RKFREILFST KGIERYIGGV ILNQETFEQT SGSGVPLTEL LKKKGIEIGI
110 120 130 140 150
KLDKGLIDYK EKEKISVGLE DLDLRCKSSA FKDATFAKWR SLFYFYDGIP
160 170 180 190 200
SEDCINENCS ILAKYAIICQ KNGLVPIVEP EVFLEGDYSM KRSYEVTRQI
210 220 230 240 250
LSTLMKYLNY ELVYIPGVLI KASYVTSGQL SNEKYTPKKV ATFTLRALLS
260 270 280 290 300
TIPCGIPGIV FLSGGHGSED AIGFLNAINM ERGCRTWSLS FSFARALTDG
310 320 330
VLETWRGDDS NIEEAQKILL ETSFKACRGA EGKLWDQE
Length:338
Mass (Da):37,917
Last modified:June 1, 2002 - v1
Checksum:i2158A1DAE05A7AF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391737 Genomic DNA. Translation: CAD24894.1.
RefSeqiXP_965859.1. XM_960766.1.

Genome annotation databases

GeneIDi860198.
KEGGiecu:ECU01_0240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391737 Genomic DNA. Translation: CAD24894.1 .
RefSeqi XP_965859.1. XM_960766.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3MBD X-ray 2.00 A 1-338 [» ]
3MBF X-ray 2.37 A 1-338 [» ]
3QRH X-ray 2.00 A 1-338 [» ]
ProteinModelPortali Q8SSM8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU01_0240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860198.
KEGGi ecu:ECU01_0240.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU01_0240.

Phylogenomic databases

eggNOGi COG3588.
HOGENOMi HOG000220876.
InParanoidi Q8SSM8.
KOi K01623.
OMAi DMEHCQY.
OrthoDBi EOG7M0P2G.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

EvolutionaryTracei Q8SSM8.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
    Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
    Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  3. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiALF_ENCCU
AccessioniPrimary (citable) accession number: Q8SSM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3