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Q8SSL7

- AGM1_ENCCU

UniProt

Q8SSL7 - AGM1_ENCCU

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Protein

Probable phosphoacetylglucosamine mutase

Gene

PCM1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Interconverts GlcNAc-6-P and GlcNAc-1-P.By similarity

Catalytic activityi

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.

Cofactori

Binds 1 magnesium ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei62 – 621Phosphoserine intermediateBy similarity
Metal bindingi62 – 621Magnesium; via phosphate groupBy similarity
Metal bindingi278 – 2781MagnesiumBy similarity
Metal bindingi280 – 2801MagnesiumBy similarity
Metal bindingi282 – 2821MagnesiumBy similarity

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphoacetylglucosamine mutase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00113; UER00530.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphoacetylglucosamine mutase (EC:5.4.2.3)
Short name:
PAGM
Alternative name(s):
Acetylglucosamine phosphomutase
N-acetylglucosamine-phosphate mutase
Gene namesi
Name:PCM1
Ordered Locus Names:ECU01_0650
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0650.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 530530Probable phosphoacetylglucosamine mutasePRO_0000381747Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU01_0650.

Structurei

3D structure databases

ProteinModelPortaliQ8SSL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphohexose mutase family.Curated

Phylogenomic databases

eggNOGiCOG1109.
HOGENOMiHOG000210027.
InParanoidiQ8SSL7.
KOiK01836.
OMAiDIVRVYA.
OrthoDBiEOG7V1G0D.

Family and domain databases

Gene3Di3.30.310.50. 1 hit.
3.40.120.10. 2 hits.
InterProiIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR016657. PAGM.
[Graphical view]
PfamiPF02878. PGM_PMM_I. 2 hits.
PF02879. PGM_PMM_II. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PIRSFiPIRSF016408. PAGM. 1 hit.
SUPFAMiSSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.
PROSITEiPS00710. PGM_PMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SSL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNALIADEN LKKPSKPAYY GTAGYRSKTS DLNNILCRAS LIAYLRSTTF
60 70 80 90 100
AGKIIGVMIT ASHNPVEYNG IKIIDHNGDM LDEVWEEYSD RIVNCDDEKL
110 120 130 140 150
AREMKKILRS CSNQSELGEG VRGHVVLGRD TRDSGERLCN NIRSVLGKLN
160 170 180 190 200
CTVDDYGVVT TPELHFLVRK CNTENRVVDK AEYMKNIAHN FNSLSSITKG
210 220 230 240 250
NLRMMIDTAN GVADMKLKEL DGMLDGKLNY EVLNDPKGIL NLDCGADFVK
260 270 280 290 300
TKKRAPRLEA LSSSGFSQAA NRICASFDGD VDRLIFFTGP KDTEIFDGDS
310 320 330 340 350
QAVFLALYIR SLLDRIESRL SIGVVLSYYS NNAAVDVLPP ESFKVVMAQT
360 370 380 390 400
GVKNFVSAAR EFDVGIYFEP NGHGSVCFSQ ACIDEIEKGS TKSHAILKIL
410 420 430 440 450
ANLFDPCIGD ALANFVIFKA LMGSADDLRK FRENPSRLLT VKIVDKNSIK
460 470 480 490 500
VDQKNQVIEP KELQDKIDVE ALSLGGRSFV RPSGTEDVVR VYAECPSEAD
510 520 530
ADLLCLKVAQ HVYDMCNGIG DHPEIDYTSK
Length:530
Mass (Da):58,611
Last modified:June 1, 2002 - v1
Checksum:iE74F296E1F93C1B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391737 Genomic DNA. Translation: CAD24935.1.
RefSeqiXP_965900.1. XM_960807.1.

Genome annotation databases

GeneIDi860240.
KEGGiecu:ECU01_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391737 Genomic DNA. Translation: CAD24935.1 .
RefSeqi XP_965900.1. XM_960807.1.

3D structure databases

ProteinModelPortali Q8SSL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU01_0650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860240.
KEGGi ecu:ECU01_0650.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU01_0650.

Phylogenomic databases

eggNOGi COG1109.
HOGENOMi HOG000210027.
InParanoidi Q8SSL7.
KOi K01836.
OMAi DIVRVYA.
OrthoDBi EOG7V1G0D.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00530 .

Family and domain databases

Gene3Di 3.30.310.50. 1 hit.
3.40.120.10. 2 hits.
InterProi IPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR016657. PAGM.
[Graphical view ]
Pfami PF02878. PGM_PMM_I. 2 hits.
PF02879. PGM_PMM_II. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view ]
PIRSFi PIRSF016408. PAGM. 1 hit.
SUPFAMi SSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.
PROSITEi PS00710. PGM_PMM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
    Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
    Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  3. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiAGM1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3