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Q8SSL7 (AGM1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable phosphoacetylglucosamine mutase

Short name=PAGM
EC=5.4.2.3
Alternative name(s):
Acetylglucosamine phosphomutase
N-acetylglucosamine-phosphate mutase
Gene names
Name:PCM1
Ordered Locus Names:ECU01_0650
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length530 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Interconverts GlcNAc-6-P and GlcNAc-1-P By similarity.

Catalytic activity

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate.

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.

Developmental stage

Expressed in late sporogonial stages.

Sequence similarities

Belongs to the phosphohexose mutase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 530530Probable phosphoacetylglucosamine mutase
PRO_0000381747

Sites

Active site621Phosphoserine intermediate By similarity
Metal binding621Magnesium; via phosphate group By similarity
Metal binding2781Magnesium By similarity
Metal binding2801Magnesium By similarity
Metal binding2821Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SSL7 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: E74F296E1F93C1B6

FASTA53058,611
        10         20         30         40         50         60 
MDNALIADEN LKKPSKPAYY GTAGYRSKTS DLNNILCRAS LIAYLRSTTF AGKIIGVMIT 

        70         80         90        100        110        120 
ASHNPVEYNG IKIIDHNGDM LDEVWEEYSD RIVNCDDEKL AREMKKILRS CSNQSELGEG 

       130        140        150        160        170        180 
VRGHVVLGRD TRDSGERLCN NIRSVLGKLN CTVDDYGVVT TPELHFLVRK CNTENRVVDK 

       190        200        210        220        230        240 
AEYMKNIAHN FNSLSSITKG NLRMMIDTAN GVADMKLKEL DGMLDGKLNY EVLNDPKGIL 

       250        260        270        280        290        300 
NLDCGADFVK TKKRAPRLEA LSSSGFSQAA NRICASFDGD VDRLIFFTGP KDTEIFDGDS 

       310        320        330        340        350        360 
QAVFLALYIR SLLDRIESRL SIGVVLSYYS NNAAVDVLPP ESFKVVMAQT GVKNFVSAAR 

       370        380        390        400        410        420 
EFDVGIYFEP NGHGSVCFSQ ACIDEIEKGS TKSHAILKIL ANLFDPCIGD ALANFVIFKA 

       430        440        450        460        470        480 
LMGSADDLRK FRENPSRLLT VKIVDKNSIK VDQKNQVIEP KELQDKIDVE ALSLGGRSFV 

       490        500        510        520        530 
RPSGTEDVVR VYAECPSEAD ADLLCLKVAQ HVYDMCNGIG DHPEIDYTSK 

« Hide

References

[1]"Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[3]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL391737 Genomic DNA. Translation: CAD24935.1.
RefSeqXP_965900.1. XM_960807.1.

3D structure databases

ProteinModelPortalQ8SSL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU01_0650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID860240.
KEGGecu:ECU01_0650.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU01_0650.

Phylogenomic databases

eggNOGCOG1109.
HOGENOMHOG000210027.
KOK01836.
OMADIVRVYA.
OrthoDBEOG7V1G0D.

Enzyme and pathway databases

UniPathwayUPA00113; UER00530.

Family and domain databases

Gene3D3.30.310.50. 1 hit.
3.40.120.10. 2 hits.
InterProIPR005844. A-D-PHexomutase_a/b/a-I.
IPR016055. A-D-PHexomutase_a/b/a-I/II/III.
IPR005845. A-D-PHexomutase_a/b/a-II.
IPR005843. A-D-PHexomutase_C.
IPR016066. A-D-PHexomutase_CS.
IPR016657. PAGM.
[Graphical view]
PANTHERPTHR22573:SF3. PTHR22573:SF3. 1 hit.
PfamPF02878. PGM_PMM_I. 2 hits.
PF02879. PGM_PMM_II. 1 hit.
PF00408. PGM_PMM_IV. 1 hit.
[Graphical view]
PIRSFPIRSF016408. PAGM. 1 hit.
SUPFAMSSF53738. SSF53738. 4 hits.
SSF55957. SSF55957. 1 hit.
PROSITEPS00710. PGM_PMM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAGM1_ENCCU
AccessionPrimary (citable) accession number: Q8SSL7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways