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Q8SSL2

- TPS1_ENCCU

UniProt

Q8SSL2 - TPS1_ENCCU

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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. Can function independently of the complex (By similarity).By similarity

Catalytic activityi

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

  1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
  2. trehalose biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Stress response

Protein family/group databases

CAZyiGT20. Glycosyltransferase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
General glucose sensor subunit 1
Trehalose synthase complex catalytic subunit TPS1
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
Ordered Locus Names:ECU01_0800
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0800.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000381753Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Component of the trehalose synthase complex.By similarity

Protein-protein interaction databases

STRINGi6035.ECU01_0800.

Structurei

3D structure databases

ProteinModelPortaliQ8SSL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

eggNOGiCOG0380.
HOGENOMiHOG000191477.
InParanoidiQ8SSL2.
KOiK00697.
OMAiRAFCDYI.
OrthoDBiEOG76QFS6.

Family and domain databases

InterProiIPR001830. Glyco_trans_20.
[Graphical view]
PfamiPF00982. Glyco_transf_20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SSL2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLVVSNRL PLTVKKSKDG FEYTKTSGGL VTGLRGISDK IRFMWLGNIS
60 70 80 90 100
GVELDEEEKK VIRKDCWEKF HSIPVFIDPV LNSNSYDGFC NAILWPIIHS
110 120 130 140 150
FKDDVAFTIK DYNAYVEYNT IFCEEICKIV EDGDIVWVHD YHLMILPEML
160 170 180 190 200
RKKSDKSFKI MFFLHAQFPP AEIMETLACR REIVSGMAHS DLIAFHSFDY
210 220 230 240 250
AINFDDTCRA NKVEVRSKLD AIPIGIDPAM FRSALKEEKT VERIKELREM
260 270 280 290 300
FRGRKILLGV DRTDYIKGMP HRVKGFQRFL EKHPEFLDNV VFLQVGVPSR
310 320 330 340 350
TSVKEYSSYI TKMNELVSET NSKFGSIESV HLYFLNKSVD FNELCALYAV
360 370 380 390 400
SDMLLVTSLQ DGMNLVALEY ISCQNENNGV LLLSSNAGAS TTLPAAVEVN
410 420 430 440 450
SWNTEEIADG IHRAITMSLE ERTERHEINR KAVDTFTSVE WAEKNLDGLC

DDWRESLML
Length:459
Mass (Da):52,575
Last modified:June 1, 2002 - v1
Checksum:i4691E0E97F948AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA. Translation: CAD24950.1.
RefSeqiXP_965915.1. XM_960822.1.

Genome annotation databases

GeneIDi860256.
KEGGiecu:ECU01_0800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA. Translation: CAD24950.1 .
RefSeqi XP_965915.1. XM_960822.1.

3D structure databases

ProteinModelPortali Q8SSL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU01_0800.

Protein family/group databases

CAZyi GT20. Glycosyltransferase Family 20.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860256.
KEGGi ecu:ECU01_0800.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU01_0800.

Phylogenomic databases

eggNOGi COG0380.
HOGENOMi HOG000191477.
InParanoidi Q8SSL2.
KOi K00697.
OMAi RAFCDYI.
OrthoDBi EOG76QFS6.

Family and domain databases

InterProi IPR001830. Glyco_trans_20.
[Graphical view ]
Pfami PF00982. Glyco_transf_20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
    Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
    Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  3. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTPS1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3