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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. Can function independently of the complex (By similarity).By similarity

Catalytic activityi

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processStress response

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
Alternative name(s):
General glucose sensor subunit 1
Trehalose synthase complex catalytic subunit TPS1
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene namesi
Name:TPS1
Ordered Locus Names:ECU01_0800
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0800

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817531 – 459Alpha,alpha-trehalose-phosphate synthase [UDP-forming]Add BLAST459

Proteomic databases

PRIDEiQ8SSL2

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Component of the trehalose synthase complex.By similarity

Protein-protein interaction databases

STRINGi284813.XP_965915.1

Structurei

3D structure databases

ProteinModelPortaliQ8SSL2
SMRiQ8SSL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 20 family.Curated

Phylogenomic databases

eggNOGiKOG1050 Eukaryota
COG0380 LUCA
HOGENOMiHOG000191477
InParanoidiQ8SSL2
KOiK00697
OMAiIEFMPIH
OrthoDBiEOG092C0LDC

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SSL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLVVSNRL PLTVKKSKDG FEYTKTSGGL VTGLRGISDK IRFMWLGNIS
60 70 80 90 100
GVELDEEEKK VIRKDCWEKF HSIPVFIDPV LNSNSYDGFC NAILWPIIHS
110 120 130 140 150
FKDDVAFTIK DYNAYVEYNT IFCEEICKIV EDGDIVWVHD YHLMILPEML
160 170 180 190 200
RKKSDKSFKI MFFLHAQFPP AEIMETLACR REIVSGMAHS DLIAFHSFDY
210 220 230 240 250
AINFDDTCRA NKVEVRSKLD AIPIGIDPAM FRSALKEEKT VERIKELREM
260 270 280 290 300
FRGRKILLGV DRTDYIKGMP HRVKGFQRFL EKHPEFLDNV VFLQVGVPSR
310 320 330 340 350
TSVKEYSSYI TKMNELVSET NSKFGSIESV HLYFLNKSVD FNELCALYAV
360 370 380 390 400
SDMLLVTSLQ DGMNLVALEY ISCQNENNGV LLLSSNAGAS TTLPAAVEVN
410 420 430 440 450
SWNTEEIADG IHRAITMSLE ERTERHEINR KAVDTFTSVE WAEKNLDGLC

DDWRESLML
Length:459
Mass (Da):52,575
Last modified:June 1, 2002 - v1
Checksum:i4691E0E97F948AA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA Translation: CAD24950.1
RefSeqiXP_965915.1, XM_960822.1

Genome annotation databases

EnsemblFungiiCAD24950; CAD24950; CAD24950
GeneIDi860256
KEGGiecu:ECU01_0800

Similar proteinsi

Entry informationi

Entry nameiTPS1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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