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Q8SSL2

- TPS1_ENCCU

UniProt

Q8SSL2 - TPS1_ENCCU

Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

Gene

TPS1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. Can function independently of the complex By similarity.By similarity

    Catalytic activityi

    UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

    GO - Molecular functioni

    1. alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to stress Source: UniProtKB-KW
    2. trehalose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Stress response

    Protein family/group databases

    CAZyiGT20. Glycosyltransferase Family 20.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha,alpha-trehalose-phosphate synthase [UDP-forming] (EC:2.4.1.15)
    Alternative name(s):
    General glucose sensor subunit 1
    Trehalose synthase complex catalytic subunit TPS1
    Trehalose-6-phosphate synthase
    UDP-glucose-glucosephosphate glucosyltransferase
    Gene namesi
    Name:TPS1
    Ordered Locus Names:ECU01_0800
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome I

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU01_0800.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459Alpha,alpha-trehalose-phosphate synthase [UDP-forming]PRO_0000381753Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in late sporogonial stages.1 Publication

    Interactioni

    Subunit structurei

    Component of the trehalose synthase complex.By similarity

    Protein-protein interaction databases

    STRINGi6035.ECU01_0800.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SSL2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 20 family.Curated

    Phylogenomic databases

    eggNOGiCOG0380.
    HOGENOMiHOG000191477.
    KOiK00697.
    OMAiRAFCDYI.
    OrthoDBiEOG76QFS6.

    Family and domain databases

    InterProiIPR001830. Glyco_trans_20.
    [Graphical view]
    PfamiPF00982. Glyco_transf_20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SSL2-1 [UniParc]FASTAAdd to Basket

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    MKLLVVSNRL PLTVKKSKDG FEYTKTSGGL VTGLRGISDK IRFMWLGNIS    50
    GVELDEEEKK VIRKDCWEKF HSIPVFIDPV LNSNSYDGFC NAILWPIIHS 100
    FKDDVAFTIK DYNAYVEYNT IFCEEICKIV EDGDIVWVHD YHLMILPEML 150
    RKKSDKSFKI MFFLHAQFPP AEIMETLACR REIVSGMAHS DLIAFHSFDY 200
    AINFDDTCRA NKVEVRSKLD AIPIGIDPAM FRSALKEEKT VERIKELREM 250
    FRGRKILLGV DRTDYIKGMP HRVKGFQRFL EKHPEFLDNV VFLQVGVPSR 300
    TSVKEYSSYI TKMNELVSET NSKFGSIESV HLYFLNKSVD FNELCALYAV 350
    SDMLLVTSLQ DGMNLVALEY ISCQNENNGV LLLSSNAGAS TTLPAAVEVN 400
    SWNTEEIADG IHRAITMSLE ERTERHEINR KAVDTFTSVE WAEKNLDGLC 450
    DDWRESLML 459
    Length:459
    Mass (Da):52,575
    Last modified:June 1, 2002 - v1
    Checksum:i4691E0E97F948AA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391737 Genomic DNA. Translation: CAD24950.1.
    RefSeqiXP_965915.1. XM_960822.1.

    Genome annotation databases

    GeneIDi860256.
    KEGGiecu:ECU01_0800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391737 Genomic DNA. Translation: CAD24950.1 .
    RefSeqi XP_965915.1. XM_960822.1.

    3D structure databases

    ProteinModelPortali Q8SSL2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU01_0800.

    Protein family/group databases

    CAZyi GT20. Glycosyltransferase Family 20.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 860256.
    KEGGi ecu:ECU01_0800.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU01_0800.

    Phylogenomic databases

    eggNOGi COG0380.
    HOGENOMi HOG000191477.
    KOi K00697.
    OMAi RAFCDYI.
    OrthoDBi EOG76QFS6.

    Family and domain databases

    InterProi IPR001830. Glyco_trans_20.
    [Graphical view ]
    Pfami PF00982. Glyco_transf_20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
      Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
      Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    3. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
      Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
      Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTPS1_ENCCU
    AccessioniPrimary (citable) accession number: Q8SSL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3