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Q8SSL2 (TPS1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]

EC=2.4.1.15
Alternative name(s):
General glucose sensor subunit 1
Trehalose synthase complex catalytic subunit TPS1
Trehalose-6-phosphate synthase
UDP-glucose-glucosephosphate glucosyltransferase
Gene names
Name:TPS1
Ordered Locus Names:ECU01_0800
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-glucose in a two step process. Can function independently of the complex By similarity.

Catalytic activity

UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

Subunit structure

Component of the trehalose synthase complex By similarity.

Subcellular location

Cytoplasm By similarity.

Developmental stage

Expressed in late sporogonial stages.

Sequence similarities

Belongs to the glycosyltransferase 20 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

trehalose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalpha,alpha-trehalose-phosphate synthase (UDP-forming) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
PRO_0000381753

Sequences

Sequence LengthMass (Da)Tools
Q8SSL2 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 4691E0E97F948AA3

FASTA45952,575
        10         20         30         40         50         60 
MKLLVVSNRL PLTVKKSKDG FEYTKTSGGL VTGLRGISDK IRFMWLGNIS GVELDEEEKK 

        70         80         90        100        110        120 
VIRKDCWEKF HSIPVFIDPV LNSNSYDGFC NAILWPIIHS FKDDVAFTIK DYNAYVEYNT 

       130        140        150        160        170        180 
IFCEEICKIV EDGDIVWVHD YHLMILPEML RKKSDKSFKI MFFLHAQFPP AEIMETLACR 

       190        200        210        220        230        240 
REIVSGMAHS DLIAFHSFDY AINFDDTCRA NKVEVRSKLD AIPIGIDPAM FRSALKEEKT 

       250        260        270        280        290        300 
VERIKELREM FRGRKILLGV DRTDYIKGMP HRVKGFQRFL EKHPEFLDNV VFLQVGVPSR 

       310        320        330        340        350        360 
TSVKEYSSYI TKMNELVSET NSKFGSIESV HLYFLNKSVD FNELCALYAV SDMLLVTSLQ 

       370        380        390        400        410        420 
DGMNLVALEY ISCQNENNGV LLLSSNAGAS TTLPAAVEVN SWNTEEIADG IHRAITMSLE 

       430        440        450 
ERTERHEINR KAVDTFTSVE WAEKNLDGLC DDWRESLML 

« Hide

References

[1]"Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[3]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL391737 Genomic DNA. Translation: CAD24950.1.
RefSeqXP_965915.1. XM_960822.1.

3D structure databases

ProteinModelPortalQ8SSL2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU01_0800.

Protein family/group databases

CAZyGT20. Glycosyltransferase Family 20.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID860256.
KEGGecu:ECU01_0800.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU01_0800.

Phylogenomic databases

eggNOGCOG0380.
HOGENOMHOG000191477.
KOK00697.
OMARAFCDYI.
OrthoDBEOG76QFS6.

Family and domain databases

InterProIPR001830. Glyco_trans_20.
[Graphical view]
PfamPF00982. Glyco_transf_20. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPS1_ENCCU
AccessionPrimary (citable) accession number: Q8SSL2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: November 13, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families