Reviewed, UniProtKB/Swiss-Prot Q8SSL0 (TPP_ENCCU)

Names and origin

Protein names

Recommended name:
    Probable trehalose-phosphatase
    EC=3.1.3.12
Alternative name(s):
    Trehalose-6-phosphate phosphatase
      Short name=TPP

Gene names

Ordered Locus Names:

ECU01_0870

Organism

Encephalitozoon cuniculi [Complete proteome]

Taxonomic identifier

6035 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Microsporidia › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length	718 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Trehalose 6-phosphate + H2O = trehalose + phosphate.
Developmental stage	Expressed in late sporogonial stages.
Sequence similarities	In the N-terminal section; belongs to the glycosyltransferase 20 family. In the C-terminal section; belongs to the trehalose phosphatase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	trehalose biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	trehalose-phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 718	718	Probable trehalose-phosphatase		PRO_0000122507
Experimental info
	Sequence conflict	421	1	R → K in CAA07262. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8SSL0-1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: B82FC7D318854CD5	FASTA	718	82,064
	10 20 30 40 50 60 MKIIVAAEEL PICASRMEPS EAIKNWISTP LKKIPHPDKA SKIQIEFGDR SKESLHLFAK 70 80 90 100 110 120 PHFMVPDMLD DDEMFFVGAP GFYSPEEFSD EDCRRIEESM KAYRCYPIFQ KRVKYSKMIE 130 140 150 160 170 180 EILGKNTYEF VQSNFDHANM FARYKEYNTR WHEKIMEIYE EGDVVWVMDH SLFLLPGMLG 190 200 210 220 230 240 NSIPVGMSAS VPFSSLLKCI PFWEQIFSSI LCCRYIEFNE SSSKESFDLL VSQKTGFCMG 250 260 270 280 290 300 DPGYKDIREP LTCVGKKGID KDVLLKMSSE VHEFEGLGKG KVILLPSDSQ THLLGVEAYL 310 320 330 340 350 360 SRYGKEITVL FLRTRVLNGD SDKQAEVMRL REYLEINYKV LSREFTPASD PEFISMLKRC 370 380 390 400 410 420 DLCHCPEVAD VCSLFGIPVV RNNPYDFFDI ADEINENLMQ RGEGSKEGSS EVIGKMEWKK 430 440 450 460 470 480 RFMTSLLSIS GMEYDVDLEP KEPRIRSSLS MDQTGHKKVD AKKKPGIRKK NREKEEAVEI 490 500 510 520 530 540 ILNNKEDANA ARIVNDFKKS KARTLVMDYD GTLTNIVARP PMAAPTQEIK DLLIRLGKIC 550 560 570 580 590 600 RVVISTGRSV EDCDKFFPKE IEVFAEHGAC HRIDGKWKEG GTFPQKDLAW RIGQFFLART 610 620 630 640 650 660 PGSELERKKT GYAFHFRNVS PLIGVKQARA LFELLMRVCK DYVKKGNHVI EVRSSKKSCA 670 680 690 700 710 MEKIEEGFVL CAGDDVADED MFDVCKGYTI KVGDQSTSAA YRVKDPENFR MLLGRLLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Putative trehalose 6-phosphate phosphatase from the chromosome I of Encephalitozoon cuniculi (Microspora)." Duffieux F., Peyret P., Roe B.A., Vivares C.P. Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)." Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P. Genome Res. 11:198-207(2001) [PubMed: 11157783] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[3]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed: 11719806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[4]	"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages." Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C. Proteomics 6:3625-3635(2006) [PubMed: 16691553] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ006825 Genomic DNA. Translation: CAA07262.1. AL391737 Genomic DNA. Translation: CAD24957.1.
RefSeq	XP_965922.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT20. Glycosyltransferase Family 20.
Genome annotation databases
GeneID	860263.
GenomeReviews	Gene locus ECU01_0870 in contig AL391737_GR.
KEGG	ecu:ECU01_0870.
NMPDR	fig|6035.1.peg.1922.
Phylogenomic databases
HOGENOM	Q8SSL0.
OMA	Q8SSL0. ENIADVM.
Enzyme and pathway databases
BRENDA	3.1.3.12. 276319.
Family and domain databases
InterPro	IPR001830. Glyco_trans_20. IPR006379. HAD-SF_hydro_IIB. IPR003337. Trehalose_PPase. [Graphical view]
Pfam	PF00982. Glyco_transf_20. 1 hit. PF02358. Trehalose_PPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01484. HAD-SF-IIB. 1 hit. TIGR00685. T6PP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TPP_ENCCU

Accession

Primary (citable) accession number: Q8SSL0
Secondary accession number(s): O96721

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	June 1, 2002
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)