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Protein

Aldose reductase

Gene

ECU01_0970

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.By similarity

Catalytic activityi

Alditol + NAD(P)+ = aldose + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei51Proton donorBy similarity1
Binding sitei111SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 20NADPSequence analysis10
Nucleotide bindingi209 – 266NADPBy similarityAdd BLAST58

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Names & Taxonomyi

Protein namesi
Recommended name:
Aldose reductase (EC:1.1.1.21)
Short name:
AR
Alternative name(s):
Aldehyde reductase
Gene namesi
Ordered Locus Names:ECU01_0970
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome I

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU01_0970

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817461 – 301Aldose reductaseAdd BLAST301

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi284813.XP_965933.1

Structurei

3D structure databases

ProteinModelPortaliQ8SSK6
SMRiQ8SSK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577 Eukaryota
COG0656 LUCA
HOGENOMiHOG000250272
InParanoidiQ8SSK6
KOiK00011
OMAiERITQNF
OrthoDBiEOG092C324N

Family and domain databases

CDDicd06660 Aldo_ket_red, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR018170 Aldo/ket_reductase_CS
IPR020471 Aldo/keto_reductase
IPR023210 NADP_OxRdtase_dom
IPR036812 NADP_OxRdtase_dom_sf
PANTHERiPTHR11732 PTHR11732, 1 hit
PfamiView protein in Pfam
PF00248 Aldo_ket_red, 1 hit
PIRSFiPIRSF000097 AKR, 1 hit
PRINTSiPR00069 ALDKETRDTASE
SUPFAMiSSF51430 SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798 ALDOKETO_REDUCTASE_1, 1 hit
PS00062 ALDOKETO_REDUCTASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SSK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MICKTQKLNN GKEIPTVGLG TWGMEDEAVL EGAIRNALSL GYRHIDTAFI
60 70 80 90 100
YGNEKMIGNI LKKLFDEGVV QRKDLFITSK LWNTFHGCPE DGLRRSLNDL
110 120 130 140 150
QMDYVDLYLI HWPVTFDPAP DGTVESCGKK YNVGKFDAVG VWKKMEALVD
160 170 180 190 200
LGLAKSIGIS NFGKANTEKI LGTCRICPAA IQIELHPYLN QKELVEFMKS
210 220 230 240 250
KGIQVISYSS LGSAPGSSAK VRDDKTIKAI AKKYGCAPSQ IILSYITAQG
260 270 280 290 300
ICVIPKSRSK EHLRENIDLK ELSREDISAI DALNTGHRYV DPPGFGPEKF

K
Length:301
Mass (Da):33,357
Last modified:June 1, 2002 - v1
Checksum:iA682F2EF7E4DE836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391737 Genomic DNA Translation: CAD24968.1
RefSeqiXP_965933.1, XM_960840.1

Genome annotation databases

EnsemblFungiiCAD24968; CAD24968; CAD24968
GeneIDi860274
KEGGiecu:ECU01_0970

Similar proteinsi

Entry informationi

Entry nameiALDR_ENCCU
AccessioniPrimary (citable) accession number: Q8SSK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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