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Q8SSK6 (ALDR_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldose reductase

Short name=AR
EC=1.1.1.21
Alternative name(s):
Aldehyde reductase
Gene names
Ordered Locus Names:ECU01_0970
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity.

Catalytic activity

Alditol + NAD(P)+ = aldose + NAD(P)H.

Subcellular location

Cytoplasm.

Developmental stage

Expressed in late sporogonial stages.

Sequence similarities

Belongs to the aldo/keto reductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalditol:NADP+ 1-oxidoreductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Aldose reductase
PRO_0000381746

Regions

Nucleotide binding11 – 2010NADP Potential
Nucleotide binding209 – 26658NADP By similarity

Sites

Active site511Proton donor By similarity
Binding site1111Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SSK6 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: A682F2EF7E4DE836

FASTA30133,357
        10         20         30         40         50         60 
MICKTQKLNN GKEIPTVGLG TWGMEDEAVL EGAIRNALSL GYRHIDTAFI YGNEKMIGNI 

        70         80         90        100        110        120 
LKKLFDEGVV QRKDLFITSK LWNTFHGCPE DGLRRSLNDL QMDYVDLYLI HWPVTFDPAP 

       130        140        150        160        170        180 
DGTVESCGKK YNVGKFDAVG VWKKMEALVD LGLAKSIGIS NFGKANTEKI LGTCRICPAA 

       190        200        210        220        230        240 
IQIELHPYLN QKELVEFMKS KGIQVISYSS LGSAPGSSAK VRDDKTIKAI AKKYGCAPSQ 

       250        260        270        280        290        300 
IILSYITAQG ICVIPKSRSK EHLRENIDLK ELSREDISAI DALNTGHRYV DPPGFGPEKF 


K 

« Hide

References

[1]"Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)."
Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P.
Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[3]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL391737 Genomic DNA. Translation: CAD24968.1.
RefSeqXP_965933.1. XM_960840.1.

3D structure databases

ProteinModelPortalQ8SSK6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU01_0970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID860274.
KEGGecu:ECU01_0970.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU01_0970.

Phylogenomic databases

eggNOGCOG0656.
HOGENOMHOG000250272.
OrthoDBEOG7WQ83S.

Family and domain databases

Gene3D3.20.20.100. 1 hit.
InterProIPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERPTHR11732. PTHR11732. 1 hit.
PfamPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFPIRSF000097. AKR. 1 hit.
PRINTSPR00069. ALDKETRDTASE.
SUPFAMSSF51430. SSF51430. 1 hit.
PROSITEPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDR_ENCCU
AccessionPrimary (citable) accession number: Q8SSK6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: November 13, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families