Q8SSK6 (ALDR_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldose reductase
Short name=AR
EC=1.1.1.21

Alternative name(s):
Aldehyde reductase

Gene names

Ordered Locus Names:

ECU01_0970

Organism

Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]

Taxonomic identifier

284813 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Microsporidia › Apansporoblastina › Unikaryonidae › Encephalitozoon › Encephalitozoon cuniculi

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies By similarity.
Catalytic activity	Alditol + NAD(P)+ = aldose + NAD(P)H.
Subcellular location	Cytoplasm.
Developmental stage	Expressed in late sporogonial stages.
Sequence similarities	Belongs to the aldo/keto reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	alditol:NADP+ 1-oxidoreductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Aldose reductase		PRO_0000381746
Regions
	Nucleotide binding	11 – 20	10	NADP Potential
	Nucleotide binding	209 – 266	58	NADP By similarity
Sites
	Active site	51	1	Proton donor By similarity
	Binding site	111	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8SSK6 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A682F2EF7E4DE836	FASTA	301	33,357
	10 20 30 40 50 60 MICKTQKLNN GKEIPTVGLG TWGMEDEAVL EGAIRNALSL GYRHIDTAFI YGNEKMIGNI 70 80 90 100 110 120 LKKLFDEGVV QRKDLFITSK LWNTFHGCPE DGLRRSLNDL QMDYVDLYLI HWPVTFDPAP 130 140 150 160 170 180 DGTVESCGKK YNVGKFDAVG VWKKMEALVD LGLAKSIGIS NFGKANTEKI LGTCRICPAA 190 200 210 220 230 240 IQIELHPYLN QKELVEFMKS KGIQVISYSS LGSAPGSSAK VRDDKTIKAI AKKYGCAPSQ 250 260 270 280 290 300 IILSYITAQG ICVIPKSRSK EHLRENIDLK ELSREDISAI DALNTGHRYV DPPGFGPEKF K

References

[1]	"Sequence and analysis of chromosome I of the amitochondriate intracellular parasite Encephalitozoon cuniculi (Microspora)." Peyret P., Katinka M.D., Duprat S., Duffieux F., Barbe V., Barbazanges M., Weissenbach J., Saurin W., Vivares C.P. Genome Res. 11:198-207(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[2]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[3]	"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages." Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C. Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL391737 Genomic DNA. Translation: CAD24968.1.
RefSeq	XP_965933.1. XM_960840.1.
3D structure databases
HSSP	HSSP built from PDB template 1HW6 based on UniProtKB P06632.
ProteinModelPortal	Q8SSK6.
ModBase	Search...
Protein-protein interaction databases
STRING	6035.ECU01_0970.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	860274.
KEGG	ecu:ECU01_0970.
Phylogenomic databases
eggNOG	COG0656.
HOGENOM	HOG000250272.
OMA	CATHKEY.
Family and domain databases
Gene3D	3.20.20.100. 1 hit.
InterPro	IPR001395. Aldo/ket_red. IPR018170. Aldo/ket_reductase_CS. IPR020471. Aldo/keto_reductase_subgr. IPR023210. NADP_OxRdtase_dom. [Graphical view]
PANTHER	PTHR11732. PTHR11732. 1 hit.
Pfam	PF00248. Aldo_ket_red. 1 hit. [Graphical view]
PIRSF	PIRSF000097. AKR. 1 hit.
PRINTS	PR00069. ALDKETRDTASE.
SUPFAM	SSF51430. Aldo/ket_red. 1 hit.
PROSITE	PS00798. ALDOKETO_REDUCTASE_1. 1 hit. PS00062. ALDOKETO_REDUCTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDR_ENCCU

Accession

Primary (citable) accession number: Q8SSK6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program