Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glutamate--tRNA ligase, cytoplasmic

Gene

ECU02_1210

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei162ATPBy similarity1
Binding sitei188GlutamateBy similarity1
Binding sitei344GlutamateBy similarity1
Binding sitei347ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi382 – 386ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate--tRNA ligase, cytoplasmic (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Ordered Locus Names:ECU02_1210
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU02_1210

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003883911 – 642Probable glutamate--tRNA ligase, cytoplasmicAdd BLAST642

Proteomic databases

PRIDEiQ8SSE4

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_584646.1

Structurei

3D structure databases

ProteinModelPortaliQ8SSE4
SMRiQ8SSE4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 154Glutamate bindingBy similarity3
Regioni326 – 330Glutamate bindingBy similarity5

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi157 – 166"HIGH" regionBy similarity10
Motifi382 – 386"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1147 Eukaryota
COG0008 LUCA
InParanoidiQ8SSE4
KOiK01885
OMAiFARMNFI
OrthoDBiEOG092C0OTH

Family and domain databases

Gene3Di2.40.240.10, 3 hits
3.40.50.620, 1 hit
HAMAPiMF_02076 Glu_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR004526 Glu-tRNA-synth_arc/euk
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd
IPR020056 Rbsml_L25/Gln-tRNA_synth_N
IPR011035 Ribosomal_L25/Gln-tRNA_synth
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PF03950 tRNA-synt_1c_C, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF50715 SSF50715, 1 hit
TIGRFAMsiTIGR00463 gltX_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SSE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGKSEFKEE LINYILLKKY GKGAQDPPVY SNALKKAPQE MFPPGLVDAL
60 70 80 90 100
DSYSINLSRS EGVEFLVLLN SLVNDIRSEE VKDIIFGMIN TNQMLTKLMK
110 120 130 140 150
DKKEVERFPD TCKMYSEQFK ANKPLLKEFN AGSRKEQGNL EIGEPSENVV
160 170 180 190 200
TRFPPEPNGR LHIGHARAAL LNWYFASKGN GRLLVRFDDT NPEKEEERFE
210 220 230 240 250
RGILSDLSLL GINEYTLSHT SDYFDKIIDL GVFLIGEGKA YADNTPQEVM
260 270 280 290 300
RDERGRGVES RCRSMDVEES KRIFKEMARG NASGYCLRAK IDMSSSNKAM
310 320 330 340 350
RDPVIFRVNE SPHHRTGDKY KVYPTYDFAC PIVDSLEGIT LSLRANEYRD
360 370 380 390 400
RNQQYYWFID NLRLRNRPKI HDFSRLNFEN TVLSKRKLKY YVDNGFVSGW
410 420 430 440 450
DDPRLATIAG IKRLGMNMEA LREYILMQGV SQKTCTISWD KVWAINRKKI
460 470 480 490 500
DPVSARYFCV QQRDAVEVSI DNTSEYTMDV PKHKKNGDLG TKEVFYSSQI
510 520 530 540 550
LLSQEDGRVL QDNEEFTLMN WGNAIVKSKT VENGTVTKME VSLNPDGDFK
560 570 580 590 600
LTKNKMSWVS KRGSVTVELA EYGNLMNDED TEDLALRFNR NSVKKEYWYA
610 620 630 640
ESAIINVREG EVIQFERNGF YYCDGFLVFN LLPFTKQKRT GN
Length:642
Mass (Da):73,964
Last modified:June 1, 2002 - v1
Checksum:iB2BC6D4B2C329BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590442 Genomic DNA Translation: CAD25150.1
RefSeqiNP_584646.1, NM_001040835.1

Genome annotation databases

EnsemblFungiiCAD25150; CAD25150; CAD25150
GeneIDi858636
KEGGiecu:ECU02_1210

Similar proteinsi

Entry informationi

Entry nameiSYEC_ENCCU
AccessioniPrimary (citable) accession number: Q8SSE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health