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Protein

DNA ligase

Gene

ECU02_1220

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processDNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:ECU02_1220Imported
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)Imported
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome II

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU02_1220

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_584647.1

Structurei

3D structure databases

ProteinModelPortaliQ8SSE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini331 – 467DNA_LIGASE_A3InterPro annotationAdd BLAST137

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967 Eukaryota
COG1793 LUCA
InParanoidiQ8SSE3
KOiK10747
OMAiRHAERNT
OrthoDBiEOG092C0FHN

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
InterProiView protein in InterPro
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SSE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKILFADFC TVLEKISMTS KRLEIQSIFT DYLRNIRETH PPSMAPALYL
60 70 80 90 100
SIATVYPEYF NKELGVGENA LVGIVAEVTG KSSKGVRNEY SKEGDLGTIA
110 120 130 140 150
MRCRVSQLLI PKTQLEVMDV FLGMRRVANE EGPRSSSSKK RIILGMMVKC
160 170 180 190 200
SPLESKYLIR LIEGRLKIGL ALKTVLISLA NVFSDDKIDE IKAAFNRQPD
210 220 230 240 250
IGRLADCLLE HGVEGLSTKF QVTPGIPLKP MLSNPSKDLT SAFKRVENKS
260 270 280 290 300
FTCEYKYDGE RVQIHRFDSS VETFSRNSEK TTEKYPDLMG LYDVSDRDFI
310 320 330 340 350
VDGEIVAYNQ KERRILPFQV LTTRKRKRVE SNKIEVHVCV FVFDLIYFDG
360 370 380 390 400
RSWIDEPLEE RRRVLHSSFK EIDGKFHFAE FKDCETPEEA ETFFNKSVEN
410 420 430 440 450
NFEGMMIKTL GSDATYLPSQ RSNKWIKIKK DYLESMSDSL DLVVMGAYYG
460 470 480 490 500
KGRRAGFYGG FLLGVYNDEE EKFEALCKIG TGFDDSILSK LHEQLSSSLC
510 520 530 540 550
SAPKNYSYKE SVKPDVWVEA KYVWEVRAAG ISLSPIYSAA WSKGEKGISL
560 570 580
RFPRFIRERD DKDVREATTS SQAYQMYLDS KVEHSEEFY
Length:589
Mass (Da):67,303
Last modified:June 1, 2002 - v1
Checksum:i4B8FEEDF085B41ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590442 Genomic DNA Translation: CAD25151.1
RefSeqiNP_584647.1, NM_001040836.1

Genome annotation databases

EnsemblFungiiCAD25151; CAD25151; CAD25151
GeneIDi858637
KEGGiecu:ECU02_1220

Similar proteinsi

Entry informationi

Entry nameiQ8SSE3_ENCCU
AccessioniPrimary (citable) accession number: Q8SSE3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health