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Protein

DNA ligase

Gene

ECU02_1220

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:ECU02_1220Imported
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)Imported
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome II

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU02_1220.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU02_1220.

Structurei

3D structure databases

ProteinModelPortaliQ8SSE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiQ8SSE3.
KOiK10747.
OMAiNPVESRY.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SSE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKILFADFC TVLEKISMTS KRLEIQSIFT DYLRNIRETH PPSMAPALYL
60 70 80 90 100
SIATVYPEYF NKELGVGENA LVGIVAEVTG KSSKGVRNEY SKEGDLGTIA
110 120 130 140 150
MRCRVSQLLI PKTQLEVMDV FLGMRRVANE EGPRSSSSKK RIILGMMVKC
160 170 180 190 200
SPLESKYLIR LIEGRLKIGL ALKTVLISLA NVFSDDKIDE IKAAFNRQPD
210 220 230 240 250
IGRLADCLLE HGVEGLSTKF QVTPGIPLKP MLSNPSKDLT SAFKRVENKS
260 270 280 290 300
FTCEYKYDGE RVQIHRFDSS VETFSRNSEK TTEKYPDLMG LYDVSDRDFI
310 320 330 340 350
VDGEIVAYNQ KERRILPFQV LTTRKRKRVE SNKIEVHVCV FVFDLIYFDG
360 370 380 390 400
RSWIDEPLEE RRRVLHSSFK EIDGKFHFAE FKDCETPEEA ETFFNKSVEN
410 420 430 440 450
NFEGMMIKTL GSDATYLPSQ RSNKWIKIKK DYLESMSDSL DLVVMGAYYG
460 470 480 490 500
KGRRAGFYGG FLLGVYNDEE EKFEALCKIG TGFDDSILSK LHEQLSSSLC
510 520 530 540 550
SAPKNYSYKE SVKPDVWVEA KYVWEVRAAG ISLSPIYSAA WSKGEKGISL
560 570 580
RFPRFIRERD DKDVREATTS SQAYQMYLDS KVEHSEEFY
Length:589
Mass (Da):67,303
Last modified:June 1, 2002 - v1
Checksum:i4B8FEEDF085B41ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590442 Genomic DNA. Translation: CAD25151.1.
RefSeqiNP_584647.1. NM_001040836.1.

Genome annotation databases

GeneIDi858637.
KEGGiecu:ECU02_1220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590442 Genomic DNA. Translation: CAD25151.1.
RefSeqiNP_584647.1. NM_001040836.1.

3D structure databases

ProteinModelPortaliQ8SSE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6035.ECU02_1220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi858637.
KEGGiecu:ECU02_1220.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU02_1220.

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiQ8SSE3.
KOiK10747.
OMAiNPVESRY.
OrthoDBiEOG7TXKRG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1Imported.

Entry informationi

Entry nameiQ8SSE3_ENCCU
AccessioniPrimary (citable) accession number: Q8SSE3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.