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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi124MagnesiumBy similarity1
Binding sitei124UTPBy similarity1
Binding sitei183UTPBy similarity1
Binding sitei210UTP; via amide nitrogenBy similarity1
Binding sitei211SubstrateBy similarity1
Metal bindingi241MagnesiumBy similarity1
Binding sitei241UTPBy similarity1
Active sitei379By similarity1
Binding sitei379UTPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP1
Ordered Locus Names:ECU03_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome III

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU03_0280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817541 – 492UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST492

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi284813.NP_597539.1

Structurei

3D structure databases

ProteinModelPortaliQ8SSC5
SMRiQ8SSC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113UTP bindingBy similarity4
Regioni112 – 113Substrate bindingBy similarity2
Regioni239 – 241Substrate bindingBy similarity3
Regioni441 – 492OligomerizationBy similarityAdd BLAST52

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2638 Eukaryota
COG4284 LUCA
HOGENOMiHOG000113618
InParanoidiQ8SSC5
KOiK00963
OMAiMEIIPNG
OrthoDBiEOG092C1XSD

Family and domain databases

CDDicd00897 UGPase_euk, 1 hit
Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR029044 Nucleotide-diphossugar_trans
IPR002618 UDPGP_fam
IPR016267 UDPGP_trans
PfamiView protein in Pfam
PF01704 UDPGP, 1 hit
PIRSFiPIRSF000806 UDPGP, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SSC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQESRSKEST LSGDEDKDVH RFLDEFDDKC TCKLLKEMKE TLEGLKKSHP
60 70 80 90 100
NPTNLDEFYR LFERYLRTRH EKIVWEKIRS PKDRIVQYNE IPEPTEKSKE
110 120 130 140 150
LLRKLAILKL NGGLGTTMGC VGPKSAITIK DGKNFIDLVV KQIRYLNSKY
160 170 180 190 200
KIDVPLILMN SFNTEGMTDK IIFRYDGIKK FSQSKFPRIS SETLLPVSPS
210 220 230 240 250
HGDKGMYPPG HGDLFYSMKN SGMLEELLEG GYEYLFVSNI DNLASTVDLK
260 270 280 290 300
LLEYFATNEL GFLMEVTDKT RADVKGGTLI EYKGALRLLE IAQVPSNKKS
310 320 330 340 350
EFTSFKKFTI FNTNNLWINL KEMKKKLEEG FFDLDIIENK KALDDETVIQ
360 370 380 390 400
LETAIGSAIK YFPNSCGVVV PRSRFLPVKT CSDLFLVESN LFVEKNGTLQ
410 420 430 440 450
LHPSRVPETC PTVKLIGENF SKIEKYEKCF KGIPDILELE VLTVSGNVLF
460 470 480 490
GKNVVLKGTV IILADEKSKI CVPDGSVLED NIIYGNLPII DH
Length:492
Mass (Da):55,910
Last modified:June 1, 2002 - v1
Checksum:i22754F479329775D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590443 Genomic DNA Translation: CAD26174.1
RefSeqiNP_597539.1, NM_001040903.1

Genome annotation databases

EnsemblFungiiCAD26174; CAD26174; CAD26174
GeneIDi858701
KEGGiecu:ECU03_0280

Similar proteinsi

Entry informationi

Entry nameiUGPA1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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