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Q8SSC5

- UGPA1_ENCCU

UniProt

Q8SSC5 - UGPA1_ENCCU

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi124 – 1241MagnesiumBy similarity
Metal bindingi241 – 2411MagnesiumBy similarity
Active sitei379 – 3791By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP1
Ordered Locus Names:ECU03_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome III

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU03_0280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492UTP--glucose-1-phosphate uridylyltransferasePRO_0000381754Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi6035.ECU03_0280.

Structurei

3D structure databases

ProteinModelPortaliQ8SSC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni441 – 49252OligomerizationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
InParanoidiQ8SSC5.
KOiK00963.
OMAiFQIFNTN.
OrthoDBiEOG7KDFKX.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SSC5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQESRSKEST LSGDEDKDVH RFLDEFDDKC TCKLLKEMKE TLEGLKKSHP
60 70 80 90 100
NPTNLDEFYR LFERYLRTRH EKIVWEKIRS PKDRIVQYNE IPEPTEKSKE
110 120 130 140 150
LLRKLAILKL NGGLGTTMGC VGPKSAITIK DGKNFIDLVV KQIRYLNSKY
160 170 180 190 200
KIDVPLILMN SFNTEGMTDK IIFRYDGIKK FSQSKFPRIS SETLLPVSPS
210 220 230 240 250
HGDKGMYPPG HGDLFYSMKN SGMLEELLEG GYEYLFVSNI DNLASTVDLK
260 270 280 290 300
LLEYFATNEL GFLMEVTDKT RADVKGGTLI EYKGALRLLE IAQVPSNKKS
310 320 330 340 350
EFTSFKKFTI FNTNNLWINL KEMKKKLEEG FFDLDIIENK KALDDETVIQ
360 370 380 390 400
LETAIGSAIK YFPNSCGVVV PRSRFLPVKT CSDLFLVESN LFVEKNGTLQ
410 420 430 440 450
LHPSRVPETC PTVKLIGENF SKIEKYEKCF KGIPDILELE VLTVSGNVLF
460 470 480 490
GKNVVLKGTV IILADEKSKI CVPDGSVLED NIIYGNLPII DH
Length:492
Mass (Da):55,910
Last modified:June 1, 2002 - v1
Checksum:i22754F479329775D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590443 Genomic DNA. Translation: CAD26174.1.
RefSeqiNP_597539.1. NM_001040903.1.

Genome annotation databases

GeneIDi858701.
KEGGiecu:ECU03_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590443 Genomic DNA. Translation: CAD26174.1 .
RefSeqi NP_597539.1. NM_001040903.1.

3D structure databases

ProteinModelPortali Q8SSC5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU03_0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 858701.
KEGGi ecu:ECU03_0280.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU03_0280.

Phylogenomic databases

eggNOGi COG4284.
HOGENOMi HOG000113618.
InParanoidi Q8SSC5.
KOi K00963.
OMAi FQIFNTN.
OrthoDBi EOG7KDFKX.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
PIRSFi PIRSF000806. UDPGP. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiUGPA1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3