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Q8SSC5 (UGPA1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UTP--glucose-1-phosphate uridylyltransferase

EC=2.7.7.9
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name=UDPGP
Short name=UGPase
Gene names
Name:UGP1
Ordered Locus Names:ECU03_0280
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a central role as a glucosyl donor in cellular metabolic pathways By similarity.

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Subunit structure

Homooctamer By similarity.

Developmental stage

Expressed in late sporogonial stages.

Sequence similarities

Belongs to the UDPGP type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492UTP--glucose-1-phosphate uridylyltransferase
PRO_0000381754

Regions

Region441 – 49252Oligomerization By similarity

Sites

Active site3791 By similarity
Metal binding1241Magnesium By similarity
Metal binding2411Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SSC5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 22754F479329775D

FASTA49255,910
        10         20         30         40         50         60 
MQESRSKEST LSGDEDKDVH RFLDEFDDKC TCKLLKEMKE TLEGLKKSHP NPTNLDEFYR 

        70         80         90        100        110        120 
LFERYLRTRH EKIVWEKIRS PKDRIVQYNE IPEPTEKSKE LLRKLAILKL NGGLGTTMGC 

       130        140        150        160        170        180 
VGPKSAITIK DGKNFIDLVV KQIRYLNSKY KIDVPLILMN SFNTEGMTDK IIFRYDGIKK 

       190        200        210        220        230        240 
FSQSKFPRIS SETLLPVSPS HGDKGMYPPG HGDLFYSMKN SGMLEELLEG GYEYLFVSNI 

       250        260        270        280        290        300 
DNLASTVDLK LLEYFATNEL GFLMEVTDKT RADVKGGTLI EYKGALRLLE IAQVPSNKKS 

       310        320        330        340        350        360 
EFTSFKKFTI FNTNNLWINL KEMKKKLEEG FFDLDIIENK KALDDETVIQ LETAIGSAIK 

       370        380        390        400        410        420 
YFPNSCGVVV PRSRFLPVKT CSDLFLVESN LFVEKNGTLQ LHPSRVPETC PTVKLIGENF 

       430        440        450        460        470        480 
SKIEKYEKCF KGIPDILELE VLTVSGNVLF GKNVVLKGTV IILADEKSKI CVPDGSVLED 

       490 
NIIYGNLPII DH 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590443 Genomic DNA. Translation: CAD26174.1.
RefSeqNP_597539.1. NM_001040903.1.

3D structure databases

ProteinModelPortalQ8SSC5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU03_0280.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID858701.
KEGGecu:ECU03_0280.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU03_0280.

Phylogenomic databases

eggNOGCOG4284.
HOGENOMHOG000113618.
KOK00963.
OMAFQIFNTN.
OrthoDBEOG7KDFKX.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_trans.
IPR016267. UDPGP_trans_subgr.
[Graphical view]
PANTHERPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFPIRSF000806. UDPGP. 1 hit.
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUGPA1_ENCCU
AccessionPrimary (citable) accession number: Q8SSC5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families