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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi124MagnesiumBy similarity1
Binding sitei124UTPBy similarity1
Binding sitei183UTPBy similarity1
Binding sitei210UTP; via amide nitrogenBy similarity1
Binding sitei211SubstrateBy similarity1
Metal bindingi241MagnesiumBy similarity1
Binding sitei241UTPBy similarity1
Active sitei379By similarity1
Binding sitei379UTPBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP1
Ordered Locus Names:ECU03_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome III

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU03_0280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817541 – 492UTP--glucose-1-phosphate uridylyltransferaseAdd BLAST492

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Homooctamer.By similarity

Protein-protein interaction databases

STRINGi284813.NP_597539.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SSC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113UTP bindingBy similarity4
Regioni112 – 113Substrate bindingBy similarity2
Regioni239 – 241Substrate bindingBy similarity3
Regioni441 – 492OligomerizationBy similarityAdd BLAST52

Sequence similaritiesi

Belongs to the UDPGP type 1 family.Curated

Phylogenomic databases

eggNOGiKOG2638. Eukaryota.
COG4284. LUCA.
HOGENOMiHOG000113618.
InParanoidiQ8SSC5.
KOiK00963.
OMAiKEGRTYC.
OrthoDBiEOG092C1XSD.

Family and domain databases

CDDicd00897. UGPase_euk. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
IPR016267. UDPGP_trans.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SSC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQESRSKEST LSGDEDKDVH RFLDEFDDKC TCKLLKEMKE TLEGLKKSHP
60 70 80 90 100
NPTNLDEFYR LFERYLRTRH EKIVWEKIRS PKDRIVQYNE IPEPTEKSKE
110 120 130 140 150
LLRKLAILKL NGGLGTTMGC VGPKSAITIK DGKNFIDLVV KQIRYLNSKY
160 170 180 190 200
KIDVPLILMN SFNTEGMTDK IIFRYDGIKK FSQSKFPRIS SETLLPVSPS
210 220 230 240 250
HGDKGMYPPG HGDLFYSMKN SGMLEELLEG GYEYLFVSNI DNLASTVDLK
260 270 280 290 300
LLEYFATNEL GFLMEVTDKT RADVKGGTLI EYKGALRLLE IAQVPSNKKS
310 320 330 340 350
EFTSFKKFTI FNTNNLWINL KEMKKKLEEG FFDLDIIENK KALDDETVIQ
360 370 380 390 400
LETAIGSAIK YFPNSCGVVV PRSRFLPVKT CSDLFLVESN LFVEKNGTLQ
410 420 430 440 450
LHPSRVPETC PTVKLIGENF SKIEKYEKCF KGIPDILELE VLTVSGNVLF
460 470 480 490
GKNVVLKGTV IILADEKSKI CVPDGSVLED NIIYGNLPII DH
Length:492
Mass (Da):55,910
Last modified:June 1, 2002 - v1
Checksum:i22754F479329775D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590443 Genomic DNA. Translation: CAD26174.1.
RefSeqiNP_597539.1. NM_001040903.1.

Genome annotation databases

EnsemblFungiiCAD26174; CAD26174; CAD26174.
GeneIDi858701.
KEGGiecu:ECU03_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590443 Genomic DNA. Translation: CAD26174.1.
RefSeqiNP_597539.1. NM_001040903.1.

3D structure databases

ProteinModelPortaliQ8SSC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284813.NP_597539.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAD26174; CAD26174; CAD26174.
GeneIDi858701.
KEGGiecu:ECU03_0280.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU03_0280.

Phylogenomic databases

eggNOGiKOG2638. Eukaryota.
COG4284. LUCA.
HOGENOMiHOG000113618.
InParanoidiQ8SSC5.
KOiK00963.
OMAiKEGRTYC.
OrthoDBiEOG092C1XSD.

Family and domain databases

CDDicd00897. UGPase_euk. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR002618. UDPGP_fam.
IPR016267. UDPGP_trans.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUGPA1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.