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Q8SSC5

- UGPA1_ENCCU

UniProt

Q8SSC5 - UGPA1_ENCCU

Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

UGP1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Plays a central role as a glucosyl donor in cellular metabolic pathways.By similarity

    Catalytic activityi

    UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi124 – 1241MagnesiumBy similarity
    Metal bindingi241 – 2411MagnesiumBy similarity
    Active sitei379 – 3791By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
    Alternative name(s):
    UDP-glucose pyrophosphorylase
    Short name:
    UDPGP
    Short name:
    UGPase
    Gene namesi
    Name:UGP1
    Ordered Locus Names:ECU03_0280
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome III

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU03_0280.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492UTP--glucose-1-phosphate uridylyltransferasePRO_0000381754Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in late sporogonial stages.1 Publication

    Interactioni

    Subunit structurei

    Homooctamer.By similarity

    Protein-protein interaction databases

    STRINGi6035.ECU03_0280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SSC5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni441 – 49252OligomerizationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UDPGP type 1 family.Curated

    Phylogenomic databases

    eggNOGiCOG4284.
    HOGENOMiHOG000113618.
    KOiK00963.
    OMAiFQIFNTN.
    OrthoDBiEOG7KDFKX.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view]
    PANTHERiPTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    PfamiPF01704. UDPGP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000806. UDPGP. 1 hit.
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8SSC5-1 [UniParc]FASTAAdd to Basket

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    MQESRSKEST LSGDEDKDVH RFLDEFDDKC TCKLLKEMKE TLEGLKKSHP    50
    NPTNLDEFYR LFERYLRTRH EKIVWEKIRS PKDRIVQYNE IPEPTEKSKE 100
    LLRKLAILKL NGGLGTTMGC VGPKSAITIK DGKNFIDLVV KQIRYLNSKY 150
    KIDVPLILMN SFNTEGMTDK IIFRYDGIKK FSQSKFPRIS SETLLPVSPS 200
    HGDKGMYPPG HGDLFYSMKN SGMLEELLEG GYEYLFVSNI DNLASTVDLK 250
    LLEYFATNEL GFLMEVTDKT RADVKGGTLI EYKGALRLLE IAQVPSNKKS 300
    EFTSFKKFTI FNTNNLWINL KEMKKKLEEG FFDLDIIENK KALDDETVIQ 350
    LETAIGSAIK YFPNSCGVVV PRSRFLPVKT CSDLFLVESN LFVEKNGTLQ 400
    LHPSRVPETC PTVKLIGENF SKIEKYEKCF KGIPDILELE VLTVSGNVLF 450
    GKNVVLKGTV IILADEKSKI CVPDGSVLED NIIYGNLPII DH 492
    Length:492
    Mass (Da):55,910
    Last modified:June 1, 2002 - v1
    Checksum:i22754F479329775D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590443 Genomic DNA. Translation: CAD26174.1.
    RefSeqiNP_597539.1. NM_001040903.1.

    Genome annotation databases

    GeneIDi858701.
    KEGGiecu:ECU03_0280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590443 Genomic DNA. Translation: CAD26174.1 .
    RefSeqi NP_597539.1. NM_001040903.1.

    3D structure databases

    ProteinModelPortali Q8SSC5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU03_0280.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 858701.
    KEGGi ecu:ECU03_0280.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU03_0280.

    Phylogenomic databases

    eggNOGi COG4284.
    HOGENOMi HOG000113618.
    KOi K00963.
    OMAi FQIFNTN.
    OrthoDBi EOG7KDFKX.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR029044. Nucleotide-diphossugar_trans.
    IPR016267. UDPGP_trans.
    IPR002618. UDPGP_trans_fam.
    [Graphical view ]
    PANTHERi PTHR11952. PTHR11952. 1 hit.
    PTHR11952:SF1. PTHR11952:SF1. 1 hit.
    Pfami PF01704. UDPGP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000806. UDPGP. 1 hit.
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
      Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
      Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiUGPA1_ENCCU
    AccessioniPrimary (citable) accession number: Q8SSC5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3