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Q8SSC5

- UGPA1_ENCCU

UniProt

Q8SSC5 - UGPA1_ENCCU

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene
UGP1, ECU03_0280
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a central role as a glucosyl donor in cellular metabolic pathways By similarity.

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi124 – 1241Magnesium By similarity
Metal bindingi241 – 2411Magnesium By similarity
Active sitei379 – 3791 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Short name:
UGPase
Gene namesi
Name:UGP1
Ordered Locus Names:ECU03_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome III

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU03_0280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492UTP--glucose-1-phosphate uridylyltransferasePRO_0000381754Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.

Interactioni

Subunit structurei

Homooctamer By similarity.

Protein-protein interaction databases

STRINGi6035.ECU03_0280.

Structurei

3D structure databases

ProteinModelPortaliQ8SSC5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni441 – 49252Oligomerization By similarityAdd
BLAST

Sequence similaritiesi

Belongs to the UDPGP type 1 family.

Phylogenomic databases

eggNOGiCOG4284.
HOGENOMiHOG000113618.
KOiK00963.
OMAiFQIFNTN.
OrthoDBiEOG7KDFKX.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view]
PANTHERiPTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
PfamiPF01704. UDPGP. 1 hit.
[Graphical view]
PIRSFiPIRSF000806. UDPGP. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SSC5-1 [UniParc]FASTAAdd to Basket

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MQESRSKEST LSGDEDKDVH RFLDEFDDKC TCKLLKEMKE TLEGLKKSHP    50
NPTNLDEFYR LFERYLRTRH EKIVWEKIRS PKDRIVQYNE IPEPTEKSKE 100
LLRKLAILKL NGGLGTTMGC VGPKSAITIK DGKNFIDLVV KQIRYLNSKY 150
KIDVPLILMN SFNTEGMTDK IIFRYDGIKK FSQSKFPRIS SETLLPVSPS 200
HGDKGMYPPG HGDLFYSMKN SGMLEELLEG GYEYLFVSNI DNLASTVDLK 250
LLEYFATNEL GFLMEVTDKT RADVKGGTLI EYKGALRLLE IAQVPSNKKS 300
EFTSFKKFTI FNTNNLWINL KEMKKKLEEG FFDLDIIENK KALDDETVIQ 350
LETAIGSAIK YFPNSCGVVV PRSRFLPVKT CSDLFLVESN LFVEKNGTLQ 400
LHPSRVPETC PTVKLIGENF SKIEKYEKCF KGIPDILELE VLTVSGNVLF 450
GKNVVLKGTV IILADEKSKI CVPDGSVLED NIIYGNLPII DH 492
Length:492
Mass (Da):55,910
Last modified:June 1, 2002 - v1
Checksum:i22754F479329775D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590443 Genomic DNA. Translation: CAD26174.1.
RefSeqiNP_597539.1. NM_001040903.1.

Genome annotation databases

GeneIDi858701.
KEGGiecu:ECU03_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590443 Genomic DNA. Translation: CAD26174.1 .
RefSeqi NP_597539.1. NM_001040903.1.

3D structure databases

ProteinModelPortali Q8SSC5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU03_0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 858701.
KEGGi ecu:ECU03_0280.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU03_0280.

Phylogenomic databases

eggNOGi COG4284.
HOGENOMi HOG000113618.
KOi K00963.
OMAi FQIFNTN.
OrthoDBi EOG7KDFKX.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR029044. Nucleotide-diphossugar_trans.
IPR016267. UDPGP_trans.
IPR002618. UDPGP_trans_fam.
[Graphical view ]
PANTHERi PTHR11952. PTHR11952. 1 hit.
PTHR11952:SF1. PTHR11952:SF1. 1 hit.
Pfami PF01704. UDPGP. 1 hit.
[Graphical view ]
PIRSFi PIRSF000806. UDPGP. 1 hit.
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiUGPA1_ENCCU
AccessioniPrimary (citable) accession number: Q8SSC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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