Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8SS24

- ITPA_ENCCU

UniProt

Q8SS24 - ITPA_ENCCU

Protein

Inosine triphosphate pyrophosphatase

Gene

ECU04_1180

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi34 – 341Magnesium or manganeseUniRule annotation
    Binding sitei46 – 461SubstrateUniRule annotation
    Metal bindingi64 – 641Magnesium or manganeseUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. deoxyribonucleoside triphosphate catabolic process Source: UniProtKB-HAMAP
    2. nucleotide metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inosine triphosphate pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Short name:
    ITPaseUniRule annotation
    Short name:
    Inosine triphosphataseUniRule annotation
    Alternative name(s):
    Non-canonical purine NTP pyrophosphataseUniRule annotation
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Short name:
    NTPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:ECU04_1180
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome IV

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU04_1180.

    Subcellular locationi

    Cytoplasm UniRule annotation. Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Inosine triphosphate pyrophosphatasePRO_0000413139Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi6035.ECU04_1180.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SS24.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 136Substrate bindingUniRule annotation
    Regioni64 – 652Substrate bindingUniRule annotation
    Regioni169 – 1702Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293320.
    KOiK01519.
    OMAiVCRGALP.
    OrthoDBiEOG74R22R.

    Family and domain databases

    Gene3Di3.90.950.10. 1 hit.
    HAMAPiMF_03148. HAM1_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR027502. ITPase.
    IPR029001. ITPase-like_fam.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8SS24-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRIYFATTN LKKLKEIRSL FEADIVHMNI PMVEIQASLE RIVDHKLNQV    50
    VPCIGEGDAV IVDDTAVAFE GLYGFPGVYI KDFLRIGSRK ISEIVGKIGN 100
    SNATAFCCLG IAHYRDGRVV KKVFFGELEG SIVESKEDGL EGFDYIFLPS 150
    GSSMCLGDMP VDEKNRISHR RIASKKLADY MASVGIIKAH GS 192
    Length:192
    Mass (Da):21,149
    Last modified:June 1, 2002 - v1
    Checksum:iF6BA42A8B3B40F82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590444 Genomic DNA. Translation: CAD25306.1.
    RefSeqiNP_584802.1. NM_001041152.1.

    Genome annotation databases

    GeneIDi858950.
    KEGGiecu:ECU04_1180.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590444 Genomic DNA. Translation: CAD25306.1 .
    RefSeqi NP_584802.1. NM_001041152.1.

    3D structure databases

    ProteinModelPortali Q8SS24.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU04_1180.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 858950.
    KEGGi ecu:ECU04_1180.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU04_1180.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293320.
    KOi K01519.
    OMAi VCRGALP.
    OrthoDBi EOG74R22R.

    Family and domain databases

    Gene3Di 3.90.950.10. 1 hit.
    HAMAPi MF_03148. HAM1_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR027502. ITPase.
    IPR029001. ITPase-like_fam.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.

    Entry informationi

    Entry nameiITPA_ENCCU
    AccessioniPrimary (citable) accession number: Q8SS24
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3