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Q8SS24

- ITPA_ENCCU

UniProt

Q8SS24 - ITPA_ENCCU

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Protein

Inosine triphosphate pyrophosphatase

Gene
ECU04_1180
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions By similarity.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi34 – 341Magnesium or manganese By similarity
Binding sitei46 – 461Substrate By similarity
Metal bindingi64 – 641Magnesium or manganese By similarity
Binding sitei164 – 1641Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. deoxyribonucleoside triphosphate catabolic process Source: UniProtKB-HAMAP
  2. nucleotide metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine triphosphate pyrophosphatase (EC:3.6.1.19)
Short name:
ITPase
Short name:
Inosine triphosphatase
Alternative name(s):
Non-canonical purine NTP pyrophosphatase
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:ECU04_1180
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome IV

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU04_1180.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192Inosine triphosphate pyrophosphataseUniRule annotationPRO_0000413139Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi6035.ECU04_1180.

Structurei

3D structure databases

ProteinModelPortaliQ8SS24.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Substrate binding By similarity
Regioni64 – 652Substrate binding By similarity
Regioni169 – 1702Substrate binding By similarity

Sequence similaritiesi

Belongs to the HAM1 NTPase family.

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293320.
KOiK01519.
OMAiVCRGALP.
OrthoDBiEOG74R22R.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_03148. HAM1_NTPase.
InterProiIPR002637. Ham1p-like.
IPR027502. ITPase.
IPR029001. ITPase-like_fam.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SS24-1 [UniParc]FASTAAdd to Basket

« Hide

MGRIYFATTN LKKLKEIRSL FEADIVHMNI PMVEIQASLE RIVDHKLNQV    50
VPCIGEGDAV IVDDTAVAFE GLYGFPGVYI KDFLRIGSRK ISEIVGKIGN 100
SNATAFCCLG IAHYRDGRVV KKVFFGELEG SIVESKEDGL EGFDYIFLPS 150
GSSMCLGDMP VDEKNRISHR RIASKKLADY MASVGIIKAH GS 192
Length:192
Mass (Da):21,149
Last modified:June 1, 2002 - v1
Checksum:iF6BA42A8B3B40F82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590444 Genomic DNA. Translation: CAD25306.1.
RefSeqiNP_584802.1. NM_001041152.1.

Genome annotation databases

GeneIDi858950.
KEGGiecu:ECU04_1180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590444 Genomic DNA. Translation: CAD25306.1 .
RefSeqi NP_584802.1. NM_001041152.1.

3D structure databases

ProteinModelPortali Q8SS24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU04_1180.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 858950.
KEGGi ecu:ECU04_1180.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU04_1180.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293320.
KOi K01519.
OMAi VCRGALP.
OrthoDBi EOG74R22R.

Family and domain databases

Gene3Di 3.90.950.10. 1 hit.
HAMAPi MF_03148. HAM1_NTPase.
InterProi IPR002637. Ham1p-like.
IPR027502. ITPase.
IPR029001. ITPase-like_fam.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiITPA_ENCCU
AccessioniPrimary (citable) accession number: Q8SS24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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