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Q8SRZ0 (PP1L_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable serine/threonine-protein phosphatase ECU05_0440

Short name=PP-1G
EC=3.1.3.16
Alternative name(s):
Protein phosphatase 1C catalytic subunit
Gene names
Ordered Locus Names:ECU05_0440
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Developmental stage

Expressed in late sporogonial stages.

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Ontologies

Keywords
   LigandManganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

nucleus

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Probable serine/threonine-protein phosphatase ECU05_0440
PRO_0000381759

Sites

Active site2581Proton donor By similarity
Metal binding1981Manganese 1 By similarity
Metal binding2001Manganese 1 By similarity
Metal binding2251Manganese 1 By similarity
Metal binding2251Manganese 2 By similarity
Metal binding2571Manganese 2 By similarity
Metal binding3091Manganese 2 By similarity
Metal binding3831Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SRZ0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: C9BFA5545B44AE5A

FASTA45751,851
        10         20         30         40         50         60 
MDIREMDLKR QEANALFKKQ MIDEALEIYK TSFLEATKSV VPGTRNDLLE EQLSLLAYNI 

        70         80         90        100        110        120 
SVVYYKRKNF PKSLAFGLES LKHRKSDKVL CKICAIYLRL GMLREYKEMY DQMVTRSSGP 

       130        140        150        160        170        180 
EVAFLLKRMK LSEVIVEKHL EKRVTLESLH ELSKEISGGR SIPADTLESI LEQGESILLG 

       190        200        210        220        230        240 
CENVVHTESS GEVLIFGDTH GQYFDVVSIL NKVFDKDRMV IFNGDYVDRG SHSVENFALL 

       250        260        270        280        290        300 
LSLKILFPGR VHLTRGNHEL SDINRVYGFY DEVKRKYPFS SDSVYRRFQD AFRALPISII 

       310        320        330        340        350        360 
VNEKVFITHG GLPEAPVKVD NLQEIYRMTD THTDELLKGL LWSDPEEILG TEESKRRAGV 

       370        380        390        400        410        420 
VFGADVTARF LERNGLDLLV RSHQAVDDGY RVHHGGKVVT IFSAPEYEGS KGPGSYLVLN 

       430        440        450 
PSAGEADEIV EISPLTRYKA VKFGRSDGKE VLRLLCN 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590445 Genomic DNA. Translation: CAD26562.1.
RefSeqNP_597385.1. NM_001041251.1.

3D structure databases

ProteinModelPortalQ8SRZ0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU05_0440.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859049.
KEGGecu:ECU05_0440.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU05_0440.

Phylogenomic databases

eggNOGCOG0639.
HOGENOMHOG000149451.
KOK04460.
OrthoDBEOG7QNVWD.

Family and domain databases

Gene3D1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR011990. TPR-like_helical.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFPIRSF033096. PPPtase_5. 1 hit.
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry namePP1L_ENCCU
AccessionPrimary (citable) accession number: Q8SRZ0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families