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Protein

Probable serine/threonine-protein phosphatase ECU05_0440

Gene

ECU05_0440

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi198Manganese 1By similarity1
Metal bindingi200Manganese 1By similarity1
Metal bindingi225Manganese 1By similarity1
Metal bindingi225Manganese 2By similarity1
Metal bindingi257Manganese 2By similarity1
Active sitei258Proton donorBy similarity1
Metal bindingi309Manganese 2By similarity1
Metal bindingi383Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein phosphatase ECU05_0440 (EC:3.1.3.16)
Short name:
PP-1G
Alternative name(s):
Protein phosphatase 1C catalytic subunit
Gene namesi
Ordered Locus Names:ECU05_0440
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0440

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817591 – 457Probable serine/threonine-protein phosphatase ECU05_0440Add BLAST457

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_597385.1

Structurei

3D structure databases

ProteinModelPortaliQ8SRZ0
SMRiQ8SRZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0374 Eukaryota
COG0639 LUCA
HOGENOMiHOG000149451
InParanoidiQ8SRZ0
KOiK04460
OrthoDBiEOG092C2ILY

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SRZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIREMDLKR QEANALFKKQ MIDEALEIYK TSFLEATKSV VPGTRNDLLE
60 70 80 90 100
EQLSLLAYNI SVVYYKRKNF PKSLAFGLES LKHRKSDKVL CKICAIYLRL
110 120 130 140 150
GMLREYKEMY DQMVTRSSGP EVAFLLKRMK LSEVIVEKHL EKRVTLESLH
160 170 180 190 200
ELSKEISGGR SIPADTLESI LEQGESILLG CENVVHTESS GEVLIFGDTH
210 220 230 240 250
GQYFDVVSIL NKVFDKDRMV IFNGDYVDRG SHSVENFALL LSLKILFPGR
260 270 280 290 300
VHLTRGNHEL SDINRVYGFY DEVKRKYPFS SDSVYRRFQD AFRALPISII
310 320 330 340 350
VNEKVFITHG GLPEAPVKVD NLQEIYRMTD THTDELLKGL LWSDPEEILG
360 370 380 390 400
TEESKRRAGV VFGADVTARF LERNGLDLLV RSHQAVDDGY RVHHGGKVVT
410 420 430 440 450
IFSAPEYEGS KGPGSYLVLN PSAGEADEIV EISPLTRYKA VKFGRSDGKE

VLRLLCN
Length:457
Mass (Da):51,851
Last modified:June 1, 2002 - v1
Checksum:iC9BFA5545B44AE5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA Translation: CAD26562.1
RefSeqiNP_597385.1, NM_001041251.1

Genome annotation databases

EnsemblFungiiCAD26562; CAD26562; CAD26562
GeneIDi859049
KEGGiecu:ECU05_0440

Similar proteinsi

Entry informationi

Entry nameiPP1L_ENCCU
AccessioniPrimary (citable) accession number: Q8SRZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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