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Q8SRZ0

- PP1L_ENCCU

UniProt

Q8SRZ0 - PP1L_ENCCU

Protein

Probable serine/threonine-protein phosphatase ECU05_0440

Gene

ECU05_0440

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi198 – 1981Manganese 1By similarity
    Metal bindingi200 – 2001Manganese 1By similarity
    Metal bindingi225 – 2251Manganese 1By similarity
    Metal bindingi225 – 2251Manganese 2By similarity
    Metal bindingi257 – 2571Manganese 2By similarity
    Active sitei258 – 2581Proton donorBy similarity
    Metal bindingi309 – 3091Manganese 2By similarity
    Metal bindingi383 – 3831Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable serine/threonine-protein phosphatase ECU05_0440 (EC:3.1.3.16)
    Short name:
    PP-1G
    Alternative name(s):
    Protein phosphatase 1C catalytic subunit
    Gene namesi
    Ordered Locus Names:ECU05_0440
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome V

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU05_0440.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. nucleus Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Probable serine/threonine-protein phosphatase ECU05_0440PRO_0000381759Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in late sporogonial stages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU05_0440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SRZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000149451.
    KOiK04460.
    OrthoDBiEOG7QNVWD.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    IPR011236. Ser/Thr_PPase_5.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF033096. PPPtase_5. 1 hit.
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8SRZ0-1 [UniParc]FASTAAdd to Basket

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    MDIREMDLKR QEANALFKKQ MIDEALEIYK TSFLEATKSV VPGTRNDLLE    50
    EQLSLLAYNI SVVYYKRKNF PKSLAFGLES LKHRKSDKVL CKICAIYLRL 100
    GMLREYKEMY DQMVTRSSGP EVAFLLKRMK LSEVIVEKHL EKRVTLESLH 150
    ELSKEISGGR SIPADTLESI LEQGESILLG CENVVHTESS GEVLIFGDTH 200
    GQYFDVVSIL NKVFDKDRMV IFNGDYVDRG SHSVENFALL LSLKILFPGR 250
    VHLTRGNHEL SDINRVYGFY DEVKRKYPFS SDSVYRRFQD AFRALPISII 300
    VNEKVFITHG GLPEAPVKVD NLQEIYRMTD THTDELLKGL LWSDPEEILG 350
    TEESKRRAGV VFGADVTARF LERNGLDLLV RSHQAVDDGY RVHHGGKVVT 400
    IFSAPEYEGS KGPGSYLVLN PSAGEADEIV EISPLTRYKA VKFGRSDGKE 450
    VLRLLCN 457
    Length:457
    Mass (Da):51,851
    Last modified:June 1, 2002 - v1
    Checksum:iC9BFA5545B44AE5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590445 Genomic DNA. Translation: CAD26562.1.
    RefSeqiNP_597385.1. NM_001041251.1.

    Genome annotation databases

    GeneIDi859049.
    KEGGiecu:ECU05_0440.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590445 Genomic DNA. Translation: CAD26562.1 .
    RefSeqi NP_597385.1. NM_001041251.1.

    3D structure databases

    ProteinModelPortali Q8SRZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU05_0440.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859049.
    KEGGi ecu:ECU05_0440.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU05_0440.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000149451.
    KOi K04460.
    OrthoDBi EOG7QNVWD.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    IPR011236. Ser/Thr_PPase_5.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF033096. PPPtase_5. 1 hit.
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
      Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
      Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPP1L_ENCCU
    AccessioniPrimary (citable) accession number: Q8SRZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3