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Protein

Probable serine/threonine-protein phosphatase ECU05_0440

Gene

ECU05_0440

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981Manganese 1By similarity
Metal bindingi200 – 2001Manganese 1By similarity
Metal bindingi225 – 2251Manganese 1By similarity
Metal bindingi225 – 2251Manganese 2By similarity
Metal bindingi257 – 2571Manganese 2By similarity
Active sitei258 – 2581Proton donorBy similarity
Metal bindingi309 – 3091Manganese 2By similarity
Metal bindingi383 – 3831Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein phosphatase ECU05_0440 (EC:3.1.3.16)
Short name:
PP-1G
Alternative name(s):
Protein phosphatase 1C catalytic subunit
Gene namesi
Ordered Locus Names:ECU05_0440
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819 Componenti: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0440.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Probable serine/threonine-protein phosphatase ECU05_0440PRO_0000381759Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU05_0440.

Structurei

3D structure databases

ProteinModelPortaliQ8SRZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000149451.
InParanoidiQ8SRZ0.
KOiK04460.
OrthoDBiEOG7QNVWD.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SRZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIREMDLKR QEANALFKKQ MIDEALEIYK TSFLEATKSV VPGTRNDLLE
60 70 80 90 100
EQLSLLAYNI SVVYYKRKNF PKSLAFGLES LKHRKSDKVL CKICAIYLRL
110 120 130 140 150
GMLREYKEMY DQMVTRSSGP EVAFLLKRMK LSEVIVEKHL EKRVTLESLH
160 170 180 190 200
ELSKEISGGR SIPADTLESI LEQGESILLG CENVVHTESS GEVLIFGDTH
210 220 230 240 250
GQYFDVVSIL NKVFDKDRMV IFNGDYVDRG SHSVENFALL LSLKILFPGR
260 270 280 290 300
VHLTRGNHEL SDINRVYGFY DEVKRKYPFS SDSVYRRFQD AFRALPISII
310 320 330 340 350
VNEKVFITHG GLPEAPVKVD NLQEIYRMTD THTDELLKGL LWSDPEEILG
360 370 380 390 400
TEESKRRAGV VFGADVTARF LERNGLDLLV RSHQAVDDGY RVHHGGKVVT
410 420 430 440 450
IFSAPEYEGS KGPGSYLVLN PSAGEADEIV EISPLTRYKA VKFGRSDGKE

VLRLLCN
Length:457
Mass (Da):51,851
Last modified:June 1, 2002 - v1
Checksum:iC9BFA5545B44AE5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26562.1.
RefSeqiNP_597385.1. NM_001041251.1.

Genome annotation databases

GeneIDi859049.
KEGGiecu:ECU05_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26562.1.
RefSeqiNP_597385.1. NM_001041251.1.

3D structure databases

ProteinModelPortaliQ8SRZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6035.ECU05_0440.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi859049.
KEGGiecu:ECU05_0440.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0440.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000149451.
InParanoidiQ8SRZ0.
KOiK04460.
OrthoDBiEOG7QNVWD.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPP1L_ENCCU
AccessioniPrimary (citable) accession number: Q8SRZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.