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Protein

Probable serine/threonine-protein phosphatase ECU05_0440

Gene

ECU05_0440

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi198Manganese 1By similarity1
Metal bindingi200Manganese 1By similarity1
Metal bindingi225Manganese 1By similarity1
Metal bindingi225Manganese 2By similarity1
Metal bindingi257Manganese 2By similarity1
Active sitei258Proton donorBy similarity1
Metal bindingi309Manganese 2By similarity1
Metal bindingi383Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein phosphatase ECU05_0440 (EC:3.1.3.16)
Short name:
PP-1G
Alternative name(s):
Protein phosphatase 1C catalytic subunit
Gene namesi
Ordered Locus Names:ECU05_0440
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0440.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817591 – 457Probable serine/threonine-protein phosphatase ECU05_0440Add BLAST457

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_597385.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SRZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0374. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000149451.
InParanoidiQ8SRZ0.
KOiK04460.
OrthoDBiEOG092C2ILY.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR11668:SF21. PTHR11668:SF21. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SRZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIREMDLKR QEANALFKKQ MIDEALEIYK TSFLEATKSV VPGTRNDLLE
60 70 80 90 100
EQLSLLAYNI SVVYYKRKNF PKSLAFGLES LKHRKSDKVL CKICAIYLRL
110 120 130 140 150
GMLREYKEMY DQMVTRSSGP EVAFLLKRMK LSEVIVEKHL EKRVTLESLH
160 170 180 190 200
ELSKEISGGR SIPADTLESI LEQGESILLG CENVVHTESS GEVLIFGDTH
210 220 230 240 250
GQYFDVVSIL NKVFDKDRMV IFNGDYVDRG SHSVENFALL LSLKILFPGR
260 270 280 290 300
VHLTRGNHEL SDINRVYGFY DEVKRKYPFS SDSVYRRFQD AFRALPISII
310 320 330 340 350
VNEKVFITHG GLPEAPVKVD NLQEIYRMTD THTDELLKGL LWSDPEEILG
360 370 380 390 400
TEESKRRAGV VFGADVTARF LERNGLDLLV RSHQAVDDGY RVHHGGKVVT
410 420 430 440 450
IFSAPEYEGS KGPGSYLVLN PSAGEADEIV EISPLTRYKA VKFGRSDGKE

VLRLLCN
Length:457
Mass (Da):51,851
Last modified:June 1, 2002 - v1
Checksum:iC9BFA5545B44AE5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26562.1.
RefSeqiNP_597385.1. NM_001041251.1.

Genome annotation databases

EnsemblFungiiCAD26562; CAD26562; CAD26562.
GeneIDi859049.
KEGGiecu:ECU05_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26562.1.
RefSeqiNP_597385.1. NM_001041251.1.

3D structure databases

ProteinModelPortaliQ8SRZ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284813.NP_597385.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAD26562; CAD26562; CAD26562.
GeneIDi859049.
KEGGiecu:ECU05_0440.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0440.

Phylogenomic databases

eggNOGiKOG0374. Eukaryota.
COG0639. LUCA.
HOGENOMiHOG000149451.
InParanoidiQ8SRZ0.
KOiK04460.
OrthoDBiEOG092C2ILY.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR11668:SF21. PTHR11668:SF21. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPP1L_ENCCU
AccessioniPrimary (citable) accession number: Q8SRZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.