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Q8SRZ0

- PP1L_ENCCU

UniProt

Q8SRZ0 - PP1L_ENCCU

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Protein
Probable serine/threonine-protein phosphatase ECU05_0440
Gene
ECU05_0440
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi198 – 1981Manganese 1 By similarity
Metal bindingi200 – 2001Manganese 1 By similarity
Metal bindingi225 – 2251Manganese 1 By similarity
Metal bindingi225 – 2251Manganese 2 By similarity
Metal bindingi257 – 2571Manganese 2 By similarity
Active sitei258 – 2581Proton donor By similarity
Metal bindingi309 – 3091Manganese 2 By similarity
Metal bindingi383 – 3831Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein phosphatase ECU05_0440 (EC:3.1.3.16)
Short name:
PP-1G
Alternative name(s):
Protein phosphatase 1C catalytic subunit
Gene namesi
Ordered Locus Names:ECU05_0440
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0440.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Probable serine/threonine-protein phosphatase ECU05_0440
PRO_0000381759Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU05_0440.

Structurei

3D structure databases

ProteinModelPortaliQ8SRZ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000149451.
KOiK04460.
OrthoDBiEOG7QNVWD.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR011990. TPR-like_helical.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF033096. PPPtase_5. 1 hit.
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SRZ0-1 [UniParc]FASTAAdd to Basket

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MDIREMDLKR QEANALFKKQ MIDEALEIYK TSFLEATKSV VPGTRNDLLE    50
EQLSLLAYNI SVVYYKRKNF PKSLAFGLES LKHRKSDKVL CKICAIYLRL 100
GMLREYKEMY DQMVTRSSGP EVAFLLKRMK LSEVIVEKHL EKRVTLESLH 150
ELSKEISGGR SIPADTLESI LEQGESILLG CENVVHTESS GEVLIFGDTH 200
GQYFDVVSIL NKVFDKDRMV IFNGDYVDRG SHSVENFALL LSLKILFPGR 250
VHLTRGNHEL SDINRVYGFY DEVKRKYPFS SDSVYRRFQD AFRALPISII 300
VNEKVFITHG GLPEAPVKVD NLQEIYRMTD THTDELLKGL LWSDPEEILG 350
TEESKRRAGV VFGADVTARF LERNGLDLLV RSHQAVDDGY RVHHGGKVVT 400
IFSAPEYEGS KGPGSYLVLN PSAGEADEIV EISPLTRYKA VKFGRSDGKE 450
VLRLLCN 457
Length:457
Mass (Da):51,851
Last modified:June 1, 2002 - v1
Checksum:iC9BFA5545B44AE5A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590445 Genomic DNA. Translation: CAD26562.1.
RefSeqiNP_597385.1. NM_001041251.1.

Genome annotation databases

GeneIDi859049.
KEGGiecu:ECU05_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590445 Genomic DNA. Translation: CAD26562.1 .
RefSeqi NP_597385.1. NM_001041251.1.

3D structure databases

ProteinModelPortali Q8SRZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU05_0440.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859049.
KEGGi ecu:ECU05_0440.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU05_0440.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000149451.
KOi K04460.
OrthoDBi EOG7QNVWD.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR011236. Ser/Thr_PPase_5.
IPR011990. TPR-like_helical.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PIRSFi PIRSF033096. PPPtase_5. 1 hit.
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPP1L_ENCCU
AccessioniPrimary (citable) accession number: Q8SRZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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