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Q8SRY1

- G6PI_ENCCU

UniProt

Q8SRY1 - G6PI_ENCCU

Protein

Probable glucose-6-phosphate isomerase

Gene

ECU05_0650

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei340 – 3401Proton donorBy similarity
    Active sitei365 – 3651By similarity
    Active sitei474 – 4741By similarity

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glucose-6-phosphate isomerase (EC:5.3.1.9)
    Short name:
    GPI
    Alternative name(s):
    Phosphoglucose isomerase
    Short name:
    PGI
    Phosphohexose isomerase
    Short name:
    PHI
    Gene namesi
    Ordered Locus Names:ECU05_0650
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome V

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU05_0650.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Probable glucose-6-phosphate isomerasePRO_0000180574Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in late sporogonial stages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU05_0650.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SRY1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.Curated

    Phylogenomic databases

    eggNOGiCOG0166.
    HOGENOMiHOG000261371.
    KOiK01810.
    OMAiMIALTHY.
    OrthoDBiEOG7N0CDV.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SRY1-1 [UniParc]FASTAAdd to Basket

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    MMRTEIKSLF ENDRDRVKKL TRRASVGDEF IYYDFSKTHL TEEIVDGYLE    50
    KMKDFGEKID GMFGGERINF TENRKVLHVA LRDKEVLRMV EGHGDAKLDE 100
    DRRMVYDELM KIKAFVEDFD SGRVCGVTGK KLEIVVNIGI GGSDLGPRMV 150
    CDALGHYGRR GVETYFISNI DATDTIRVFE KIDPERALFI VVSKTFTTLE 200
    TIKNAELAMK LLERKLGRDR SEIASKHFVA VSSNVQEVGK HNISRVFSMW 250
    DFVGGRFSLW SAVGMSIALY VGFNNFMRLL KGASAVDEDF RRNRGRSNAE 300
    MIHAIAELFY SENGFNNKCI VCYDQYMEKF YLYLQQAEME SNGKQSERGD 350
    TGLIVWGGLG TNTQHSFFQL LHQGTRDVLV ELLMPLKPLH EEKEYHNMVV 400
    SNCLAQSRGL MVGKKEGSAK ESFRGNRPTI TVCYSKLTPE TLGAMIAHYE 450
    HKIFILGLYW GINSFDQPGV TLGKKIATEV LETLECRGDR KYDESTSEIL 500
    RLLGCCKK 508
    Length:508
    Mass (Da):57,867
    Last modified:June 1, 2002 - v1
    Checksum:i65376327480E7C8E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590445 Genomic DNA. Translation: CAD26584.1.
    RefSeqiNP_597407.1. NM_001041273.1.

    Genome annotation databases

    GeneIDi859072.
    KEGGiecu:ECU05_0650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590445 Genomic DNA. Translation: CAD26584.1 .
    RefSeqi NP_597407.1. NM_001041273.1.

    3D structure databases

    ProteinModelPortali Q8SRY1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU05_0650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859072.
    KEGGi ecu:ECU05_0650.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU05_0650.

    Phylogenomic databases

    eggNOGi COG0166.
    HOGENOMi HOG000261371.
    KOi K01810.
    OMAi MIALTHY.
    OrthoDBi EOG7N0CDV.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
      Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
      Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiG6PI_ENCCU
    AccessioniPrimary (citable) accession number: Q8SRY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3