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Q8SRY1 (G6PI_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Ordered Locus Names:ECU05_0650
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Developmental stage

Expressed in late sporogonial stages. HAMAP-Rule MF_00473

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolytic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Probable glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180574

Sites

Active site3401Proton donor By similarity
Active site3651 By similarity
Active site4741 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SRY1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 65376327480E7C8E

FASTA50857,867
        10         20         30         40         50         60 
MMRTEIKSLF ENDRDRVKKL TRRASVGDEF IYYDFSKTHL TEEIVDGYLE KMKDFGEKID 

        70         80         90        100        110        120 
GMFGGERINF TENRKVLHVA LRDKEVLRMV EGHGDAKLDE DRRMVYDELM KIKAFVEDFD 

       130        140        150        160        170        180 
SGRVCGVTGK KLEIVVNIGI GGSDLGPRMV CDALGHYGRR GVETYFISNI DATDTIRVFE 

       190        200        210        220        230        240 
KIDPERALFI VVSKTFTTLE TIKNAELAMK LLERKLGRDR SEIASKHFVA VSSNVQEVGK 

       250        260        270        280        290        300 
HNISRVFSMW DFVGGRFSLW SAVGMSIALY VGFNNFMRLL KGASAVDEDF RRNRGRSNAE 

       310        320        330        340        350        360 
MIHAIAELFY SENGFNNKCI VCYDQYMEKF YLYLQQAEME SNGKQSERGD TGLIVWGGLG 

       370        380        390        400        410        420 
TNTQHSFFQL LHQGTRDVLV ELLMPLKPLH EEKEYHNMVV SNCLAQSRGL MVGKKEGSAK 

       430        440        450        460        470        480 
ESFRGNRPTI TVCYSKLTPE TLGAMIAHYE HKIFILGLYW GINSFDQPGV TLGKKIATEV 

       490        500 
LETLECRGDR KYDESTSEIL RLLGCCKK 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590445 Genomic DNA. Translation: CAD26584.1.
RefSeqNP_597407.1. NM_001041273.1.

3D structure databases

ProteinModelPortalQ8SRY1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU05_0650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859072.
KEGGecu:ECU05_0650.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU05_0650.

Phylogenomic databases

eggNOGCOG0166.
HOGENOMHOG000261371.
KOK01810.
OMAMIALTHY.
OrthoDBEOG7N0CDV.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_ENCCU
AccessionPrimary (citable) accession number: Q8SRY1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways