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Q8SRY1

- G6PI_ENCCU

UniProt

Q8SRY1 - G6PI_ENCCU

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Protein

Probable glucose-6-phosphate isomerase

Gene

ECU05_0650

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei340 – 3401Proton donorBy similarity
Active sitei365 – 3651By similarity
Active sitei474 – 4741By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Ordered Locus Names:ECU05_0650
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_0650.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Probable glucose-6-phosphate isomerasePRO_0000180574Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU05_0650.

Structurei

3D structure databases

ProteinModelPortaliQ8SRY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
InParanoidiQ8SRY1.
KOiK01810.
OMAiMIALTHY.
OrthoDBiEOG7N0CDV.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRTEIKSLF ENDRDRVKKL TRRASVGDEF IYYDFSKTHL TEEIVDGYLE
60 70 80 90 100
KMKDFGEKID GMFGGERINF TENRKVLHVA LRDKEVLRMV EGHGDAKLDE
110 120 130 140 150
DRRMVYDELM KIKAFVEDFD SGRVCGVTGK KLEIVVNIGI GGSDLGPRMV
160 170 180 190 200
CDALGHYGRR GVETYFISNI DATDTIRVFE KIDPERALFI VVSKTFTTLE
210 220 230 240 250
TIKNAELAMK LLERKLGRDR SEIASKHFVA VSSNVQEVGK HNISRVFSMW
260 270 280 290 300
DFVGGRFSLW SAVGMSIALY VGFNNFMRLL KGASAVDEDF RRNRGRSNAE
310 320 330 340 350
MIHAIAELFY SENGFNNKCI VCYDQYMEKF YLYLQQAEME SNGKQSERGD
360 370 380 390 400
TGLIVWGGLG TNTQHSFFQL LHQGTRDVLV ELLMPLKPLH EEKEYHNMVV
410 420 430 440 450
SNCLAQSRGL MVGKKEGSAK ESFRGNRPTI TVCYSKLTPE TLGAMIAHYE
460 470 480 490 500
HKIFILGLYW GINSFDQPGV TLGKKIATEV LETLECRGDR KYDESTSEIL

RLLGCCKK
Length:508
Mass (Da):57,867
Last modified:June 1, 2002 - v1
Checksum:i65376327480E7C8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26584.1.
RefSeqiNP_597407.1. NM_001041273.1.

Genome annotation databases

GeneIDi859072.
KEGGiecu:ECU05_0650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26584.1 .
RefSeqi NP_597407.1. NM_001041273.1.

3D structure databases

ProteinModelPortali Q8SRY1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU05_0650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859072.
KEGGi ecu:ECU05_0650.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU05_0650.

Phylogenomic databases

eggNOGi COG0166.
HOGENOMi HOG000261371.
InParanoidi Q8SRY1.
KOi K01810.
OMAi MIALTHY.
OrthoDBi EOG7N0CDV.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiG6PI_ENCCU
AccessioniPrimary (citable) accession number: Q8SRY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3