Q8SRY1 (G6PI_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Ordered Locus Names:

ECU05_0650

Organism

Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

Taxonomic identifier

284813 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Microsporidia › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subcellular location	Cytoplasm By similarity.
Developmental stage	Expressed in late sporogonial stages. Ref.2
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Probable glucose-6-phosphate isomerase		PRO_0000180574
Sites
	Active site	340	1	Proton donor By similarity
	Active site	365	1	By similarity
	Active site	474	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8SRY1 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 65376327480E7C8E	FASTA	508	57,867
	10 20 30 40 50 60 MMRTEIKSLF ENDRDRVKKL TRRASVGDEF IYYDFSKTHL TEEIVDGYLE KMKDFGEKID 70 80 90 100 110 120 GMFGGERINF TENRKVLHVA LRDKEVLRMV EGHGDAKLDE DRRMVYDELM KIKAFVEDFD 130 140 150 160 170 180 SGRVCGVTGK KLEIVVNIGI GGSDLGPRMV CDALGHYGRR GVETYFISNI DATDTIRVFE 190 200 210 220 230 240 KIDPERALFI VVSKTFTTLE TIKNAELAMK LLERKLGRDR SEIASKHFVA VSSNVQEVGK 250 260 270 280 290 300 HNISRVFSMW DFVGGRFSLW SAVGMSIALY VGFNNFMRLL KGASAVDEDF RRNRGRSNAE 310 320 330 340 350 360 MIHAIAELFY SENGFNNKCI VCYDQYMEKF YLYLQQAEME SNGKQSERGD TGLIVWGGLG 370 380 390 400 410 420 TNTQHSFFQL LHQGTRDVLV ELLMPLKPLH EEKEYHNMVV SNCLAQSRGL MVGKKEGSAK 430 440 450 460 470 480 ESFRGNRPTI TVCYSKLTPE TLGAMIAHYE HKIFILGLYW GINSFDQPGV TLGKKIATEV 490 500 LETLECRGDR KYDESTSEIL RLLGCCKK

References

[1]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed: 11719806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[2]	"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages." Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C. Proteomics 6:3625-3635(2006) [PubMed: 16691553] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590445 Genomic DNA. Translation: CAD26584.1.
RefSeq	NP_597407.1. NM_001041273.1.
3D structure databases
ProteinModelPortal	Q8SRY1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8SRY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	859072.
GenomeReviews	Gene locus ECU05_0650 in contig AL590445_GR.
KEGG	ecu:ECU05_0650.
NMPDR	fig|6035.1.peg.554.
Organism-specific databases
EuPathDB	EupathDB:ECU05_0650.
Phylogenomic databases
eggNOG	fuNOG04321.
HOGENOM	HBG352954.
OMA	NDFLKGA.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ENCCU

Accession

Primary (citable) accession number: Q8SRY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program