Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8SRX1 (Q8SRX1_ENCCU) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:ECU05_0860
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryota › Fungi › Microsporidia › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region126 – 1283Substrate binding By similarity PIRSR PIRSR000109-2
Region185 – 1862Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1821Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1891Proton donor By similarity PIRSR PIRSR000109-1
Binding site1041Substrate By similarity PIRSR PIRSR000109-2
Binding site1901Substrate By similarity PIRSR PIRSR000109-2
Binding site2571Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2841Substrate By similarity PIRSR PIRSR000109-2
Binding site4361Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4421Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q8SRX1 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 3EF6F52A68EB0DE3

FASTA45851,172
        10         20         30         40         50         60 
MPQTPKMEIG LIGLGVMGHS LALNIVSRGY RLHVFNRTSS KTDDLVRERR DICPHYSVED 

        70         80         90        100        110        120 
LVVGIKTSPR VILLMLTSGK VVDVFLEELS RYLGKDDVVI DGGNSSYKDT IRRNRYKFGF 

       130        140        150        160        170        180 
VGCGISGGEE GARYGPSIMV GCDKDSWEKV QGFLTDISAV EVSGSKRCCV WLGEGGAGHF 

       190        200        210        220        230        240 
VKMVHNGIEY GDMAIISETY LVLKSLGLSN MEISSLFDSW NGMESESYLL RISCSILRME 

       250        260        270        280        290        300 
NERGSVLDQI ADVSGQKGTG MEAVVSSMEM GQPIPAIMEA VASRMVSYAK KKRCWLSERL 

       310        320        330        340        350        360 
EGGKGRREMS LDAARRGFYL ARMVSCVQGF NLLMRARKKH GWPYTIEDIS QVWSNGCILR 

       370        380        390        400        410        420 
GKLLDVVRSM GKERQDDFEL TSEFVSLCNE YYQDLKEMVL YSTECEVPTP TISSCLMYLN 

       430        440        450 
GMKKEEGGGN MIQAMRDYFG AHMVTMKGED EAVHVRWN

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed: 11719806] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL590445 Genomic DNA. Translation: CAD26605.1.
RefSeqNP_597428.1. NM_001041294.1.

3D structure databases

HSSPHSSP built from PDB template 2PGD based on UniProtKB P00349.
ProteinModelPortalQ8SRX1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8SRX1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859093.
GenomeReviewsGene locus ECU05_0860 in contig AL590445_GR.
KEGGecu:ECU05_0860.
NMPDRfig|6035.1.peg.575.

Organism-specific databases

EuPathDBEupathDB:ECU05_0860.

Phylogenomic databases

eggNOGfuNOG05795.
HOGENOMHBG286913.
OMASNYPDTN.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ8SRX1_ENCCU
AccessionPrimary (citable) accession number: Q8SRX1
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: December 14, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info