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Protein

Probable proteasome subunit alpha type-5

Gene

PUP2

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-5 (EC:3.4.25.1)
Alternative name(s):
26S proteasome alpha-type subunit PUP2
Multicatalytic endopeptidase complex subunit PUP2
Gene namesi
Name:PUP2
Ordered Locus Names:ECU05_1400
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_1400.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003827561 – 232Probable proteasome subunit alpha type-5Add BLAST232

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi284813.NP_597483.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SRU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176. Eukaryota.
COG0638. LUCA.
HOGENOMiHOG000091085.
InParanoidiQ8SRU3.
KOiK02729.
OMAiQMGYDRA.
OrthoDBiEOG092C47D8.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR000426. Proteasome_asu_N.
IPR001353. Proteasome_sua/b.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
SMARTiView protein in SMART
SM00948. Proteasome_A_N. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SRU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFKQSVNT YSSEGRIHQI EYAMKAMNLG TTTIGVRTKE FVILCSEKKI
60 70 80 90 100
LSTLQNPKSV VKHYKIYDHI VLGFSGISGD TKTIVKRSRD FCISHTHMYG
110 120 130 140 150
ENISVERLLK YLSSLSLRFG EEDEAKMIFR RPFGVSLIIA GFDTEPRLYS
160 170 180 190 200
LDPSGSYISY KAKAIGSGHE VVEGILENEY EEYSGLDQSL RKVLCTLSKV
210 220 230
MKDKISKDNV EVVVVTQEES KFLTPEEVSV YL
Length:232
Mass (Da):26,291
Last modified:June 1, 2002 - v1
Checksum:i9F8E7CC6EDBECF13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA. Translation: CAD26660.1.
RefSeqiNP_597483.1. NM_001041349.1.

Genome annotation databases

GeneIDi859150.
KEGGiecu:ECU05_1400.

Similar proteinsi

Entry informationi

Entry nameiPSA5_ENCCU
AccessioniPrimary (citable) accession number: Q8SRU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: November 22, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families