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Protein

Probable proteasome subunit alpha type-5

Gene

PUP2

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-5 (EC:3.4.25.1)
Alternative name(s):
26S proteasome alpha-type subunit PUP2
Multicatalytic endopeptidase complex subunit PUP2
Gene namesi
Name:PUP2
Ordered Locus Names:ECU05_1400
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome V

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU05_1400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003827561 – 232Probable proteasome subunit alpha type-5Add BLAST232

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi284813.NP_597483.1

Structurei

3D structure databases

ProteinModelPortaliQ8SRU3
SMRiQ8SRU3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0176 Eukaryota
COG0638 LUCA
HOGENOMiHOG000091085
InParanoidiQ8SRU3
KOiK02729
OMAiFQVEYAR
OrthoDBiEOG092C47D8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR000426 Proteasome_asu_N
IPR001353 Proteasome_sua/b
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SRU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDFKQSVNT YSSEGRIHQI EYAMKAMNLG TTTIGVRTKE FVILCSEKKI
60 70 80 90 100
LSTLQNPKSV VKHYKIYDHI VLGFSGISGD TKTIVKRSRD FCISHTHMYG
110 120 130 140 150
ENISVERLLK YLSSLSLRFG EEDEAKMIFR RPFGVSLIIA GFDTEPRLYS
160 170 180 190 200
LDPSGSYISY KAKAIGSGHE VVEGILENEY EEYSGLDQSL RKVLCTLSKV
210 220 230
MKDKISKDNV EVVVVTQEES KFLTPEEVSV YL
Length:232
Mass (Da):26,291
Last modified:June 1, 2002 - v1
Checksum:i9F8E7CC6EDBECF13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590445 Genomic DNA Translation: CAD26660.1
RefSeqiNP_597483.1, NM_001041349.1

Genome annotation databases

EnsemblFungiiCAD26660; CAD26660; CAD26660
GeneIDi859150
KEGGiecu:ECU05_1400

Similar proteinsi

Entry informationi

Entry nameiPSA5_ENCCU
AccessioniPrimary (citable) accession number: Q8SRU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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