Q8SRT0 (PTP2_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polar tube protein 2

Gene names

Name:	PTP2
Ordered Locus Names:	ECU06_0240

Organism

Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]

Taxonomic identifier

284813 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Microsporidia › Apansporoblastina › Unikaryonidae › Encephalitozoon › Encephalitozoon cuniculi

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.
Subunit structure	Interacts with PTP1 and PTP3. Ref.4
Subcellular location	Spore polar tube.
Developmental stage	Expressed in late sporogonial stages.

Ontologies

Keywords
Biological process	Sporulation
Domain	Repeat Signal
PTM	Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	polar tube Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 277	259	Polar tube protein 2		PRO_0000377525
Amino acid modifications
	Glycosylation	134	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8SRT0 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 75FADFE9E706641E	FASTA	277	30,076
	10 20 30 40 50 60 MLLLLAITAV VSATMVHPSA VVPQPAAPLH VVPPQQQMGM VNGCTSKKLE GAEIMRRNMI 70 80 90 100 110 120 ECQKRSSEAT KAMIERANEK AVESFNKEVS KGPSQKDGGQ CIEKAVQGTD RCILAGIIDK 130 140 150 160 170 180 AVNKRKYRIS DVENSTSLYR GDKLIALIVN VDYGLQPITK PKKKKSKIMA NLPQPKREMY 190 200 210 220 230 240 FNQIGQLVGA RGTFPQENKE DCKPCEGPKK TVETTSEKCN LGCELKGTSA LISKAIQKKE 250 260 270 VKDTKEGEKS ASQDSDGEGT AEDAEVQQPS ADGEGLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Microsporidian invasion apparatus: identification of a novel polar tube protein and evidence for clustering of ptp1 and ptp2 genes in three Encephalitozoon species." Delbac F., Peuvel I., Metenier G., Peyretaillade E., Vivares C.P. Infect. Immun. 69:1016-1024(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 105-119, SUCELLULAR LOCATION.
[2]	"Microsporidium polar tube proteins, nucleic acids coding for said proteins and their uses." Vivares C.P., Danchin A., Delbac F. Patent number WO0001724, 13-JAN-2000 Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[4]	"The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi." Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F. Mol. Biochem. Parasitol. 122:69-80(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PTP1 AND PTP3.
[5]	"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages." Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C. Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AX007050 Genomic DNA. No translation available. AL590446 Genomic DNA. Translation: CAD25384.1.
RefSeq	NP_585780.1. NM_001041402.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	859203.
KEGG	ecu:ECU06_0240.
Phylogenomic databases
HOGENOM	HOG000115779.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PTP2_ENCCU

Accession

Primary (citable) accession number: Q8SRT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program