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Protein

Polar tube protein 2

Gene

PTP2

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

GO - Biological processi

  1. sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Sporulation

Names & Taxonomyi

Protein namesi
Recommended name:
Polar tube protein 2
Gene namesi
Name:PTP2
Ordered Locus Names:ECU06_0240
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0240.

Subcellular locationi

  1. Spore polar tube 1 Publication

GO - Cellular componenti

  1. polar tube Source: CACAO
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 277259Polar tube protein 2PRO_0000377525Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Interacts with PTP1 and PTP3.1 Publication

Family & Domainsi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOGENOMiHOG000115779.
InParanoidiQ8SRT0.
OrthoDBiEOG708W9M.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SRT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLLAITAV VSATMVHPSA VVPQPAAPLH VVPPQQQMGM VNGCTSKKLE
60 70 80 90 100
GAEIMRRNMI ECQKRSSEAT KAMIERANEK AVESFNKEVS KGPSQKDGGQ
110 120 130 140 150
CIEKAVQGTD RCILAGIIDK AVNKRKYRIS DVENSTSLYR GDKLIALIVN
160 170 180 190 200
VDYGLQPITK PKKKKSKIMA NLPQPKREMY FNQIGQLVGA RGTFPQENKE
210 220 230 240 250
DCKPCEGPKK TVETTSEKCN LGCELKGTSA LISKAIQKKE VKDTKEGEKS
260 270
ASQDSDGEGT AEDAEVQQPS ADGEGLE
Length:277
Mass (Da):30,076
Last modified:June 1, 2002 - v1
Checksum:i75FADFE9E706641E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AX007050 Genomic DNA. No translation available.
AL590446 Genomic DNA. Translation: CAD25384.1.
RefSeqiNP_585780.1. NM_001041402.1.

Genome annotation databases

GeneIDi859203.
KEGGiecu:ECU06_0240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AX007050 Genomic DNA. No translation available.
AL590446 Genomic DNA. Translation: CAD25384.1.
RefSeqiNP_585780.1. NM_001041402.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi859203.
KEGGiecu:ECU06_0240.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0240.

Phylogenomic databases

HOGENOMiHOG000115779.
InParanoidiQ8SRT0.
OrthoDBiEOG708W9M.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Microsporidian invasion apparatus: identification of a novel polar tube protein and evidence for clustering of ptp1 and ptp2 genes in three Encephalitozoon species."
    Delbac F., Peuvel I., Metenier G., Peyretaillade E., Vivares C.P.
    Infect. Immun. 69:1016-1024(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 105-119, SUBCELLULAR LOCATION.
  2. "Microsporidium polar tube proteins, nucleic acids coding for said proteins and their uses."
    Vivares C.P., Danchin A., Delbac F.
    Patent number WO0001724, 13-JAN-2000
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  4. "The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi."
    Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.
    Mol. Biochem. Parasitol. 122:69-80(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTP1 AND PTP3.
  5. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPTP2_ENCCU
AccessioniPrimary (citable) accession number: Q8SRT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 2002
Last modified: April 29, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.