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Q8SRT0 (PTP2_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Polar tube protein 2
Gene names
Name:PTP2
Ordered Locus Names:ECU06_0240
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.

Subunit structure

Interacts with PTP1 and PTP3. Ref.4

Subcellular location

Spore polar tube Ref.1.

Developmental stage

Expressed in late sporogonial stages.

Ontologies

Keywords
   Biological processSporulation
   DomainRepeat
Signal
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processsporulation resulting in formation of a cellular spore

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentpolar tube

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 277259Polar tube protein 2
PRO_0000377525

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8SRT0 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 75FADFE9E706641E

FASTA27730,076
        10         20         30         40         50         60 
MLLLLAITAV VSATMVHPSA VVPQPAAPLH VVPPQQQMGM VNGCTSKKLE GAEIMRRNMI 

        70         80         90        100        110        120 
ECQKRSSEAT KAMIERANEK AVESFNKEVS KGPSQKDGGQ CIEKAVQGTD RCILAGIIDK 

       130        140        150        160        170        180 
AVNKRKYRIS DVENSTSLYR GDKLIALIVN VDYGLQPITK PKKKKSKIMA NLPQPKREMY 

       190        200        210        220        230        240 
FNQIGQLVGA RGTFPQENKE DCKPCEGPKK TVETTSEKCN LGCELKGTSA LISKAIQKKE 

       250        260        270 
VKDTKEGEKS ASQDSDGEGT AEDAEVQQPS ADGEGLE 

« Hide

References

« Hide 'large scale' references
[1]"Microsporidian invasion apparatus: identification of a novel polar tube protein and evidence for clustering of ptp1 and ptp2 genes in three Encephalitozoon species."
Delbac F., Peuvel I., Metenier G., Peyretaillade E., Vivares C.P.
Infect. Immun. 69:1016-1024(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 105-119, SUBCELLULAR LOCATION.
[2]"Microsporidium polar tube proteins, nucleic acids coding for said proteins and their uses."
Vivares C.P., Danchin A., Delbac F.
Patent number WO0001724, 13-JAN-2000
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[4]"The microsporidian polar tube: evidence for a third polar tube protein (PTP3) in Encephalitozoon cuniculi."
Peuvel I., Peyret P., Metenier G., Vivares C.P., Delbac F.
Mol. Biochem. Parasitol. 122:69-80(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH PTP1 AND PTP3.
[5]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AX007050 Genomic DNA. No translation available.
AL590446 Genomic DNA. Translation: CAD25384.1.
RefSeqNP_585780.1. NM_001041402.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859203.
KEGGecu:ECU06_0240.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU06_0240.

Phylogenomic databases

HOGENOMHOG000115779.
OrthoDBEOG708W9M.

Family and domain databases

ProtoNetSearch...

Entry information

Entry namePTP2_ENCCU
AccessionPrimary (citable) accession number: Q8SRT0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program