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Q8SRS8

- SYLC_ENCCU

UniProt

Q8SRS8 - SYLC_ENCCU

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Protein

Probable leucine--tRNA ligase, cytoplasmic

Gene

ECU06_0280

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei547 – 5471ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Ordered Locus Names:ECU06_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0280.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Probable leucine--tRNA ligase, cytoplasmicPRO_0000388413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU06_0280.

Structurei

3D structure databases

ProteinModelPortaliQ8SRS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" regionBy similarityAdd
BLAST
Motifi544 – 5485"KMSKS" regionBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000149408.
InParanoidiQ8SRS8.
KOiK01869.
OMAiYSKFVEW.
OrthoDBiEOG7TTQH2.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEERSKLRYL SMLEVERDTI SDVSEKRKFF VTFTYPYMNG RLHLGHLFSI
60 70 80 90 100
SKADFFSYYK ELQGYNVLFP FSFHCTGMPI SASAKKLAEE LSGEKVDLSV
110 120 130 140 150
KKIIEDLGFD DVKPFTDPVH WVRTFPGLCE RSLKRFHGNI DWRRSFITTD
160 170 180 190 200
INKYYDSFIK WQFNRLNELG HLSFGKRHSI FCPVDKQPCL DHDRRKGENV
210 220 230 240 250
KPVGVVLCKL RFSEGILLAR IKQGCVPSKA VVGSRCDFIG FEYCNEKYFA
260 270 280 290 300
EKDVFENVDA QASGICVRES VKGDFFGGRR FSGFGKEVVC DAIEKDVPCV
310 320 330 340 350
VKGTQDKKDP SLAEYIKNEI ELISKVESTE TQLAETKDLL KFYEPEEEVI
360 370 380 390 400
SRSGGKCIVA LTDQWYINYC DPEWKKKVKR CIENLVCTDD TRAILEDGLE
410 420 430 440 450
WIGKWGFSRS FGLGTRIPWD SEYLIDSLSD STIYMAMYTF KHFLYRDLEG
460 470 480 490 500
KDELFPSNRL SDDVWNYIFL NRSITEDLAP YEEILSNCRE SFNYFYPIDL
510 520 530 540 550
RVGGKDLLKN HLIFFLFNHV ALFEEKHWPK RMFTNGHLML NSEKMSKSSG
560 570 580 590 600
NYMTVDESLD KFGVSSTRMC LAVCGDGNED ANFVESNANA FVLKLYSYVK
610 620 630 640 650
MIEELCTGRS LNPCILDLMK GYGEMGFADR FLMQTISMNV AHATRAHEDM
660 670 680 690 700
TYRDVVKYGF YEMVHAKEMY HILGGTNNEI LFLLCKAMTQ LLYPIIPSLA
710 720 730 740 750
RYLIETYFYS NFSLPVPFLS DTAEIDGVSY LKNTLKRLVA QKRRKKRCEV
760 770 780 790 800
VEILVGVEYS EWKRKCMSII DQIACECKVL NINVSEEMKT GESQFVPKII
810 820 830 840 850
DAVREVLKEF GIPEKKGILF SMDYLNHPEN YSVKFNEYEV LKAHKYYIEN
860 870
NTGLEVIVCV SPRADPGTPL FEFK
Length:874
Mass (Da):101,082
Last modified:June 1, 2002 - v1
Checksum:i2021A5BAFA798E90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590446 Genomic DNA. Translation: CAD25388.1.
RefSeqiNP_585784.1. NM_001041406.1.

Genome annotation databases

GeneIDi859207.
KEGGiecu:ECU06_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590446 Genomic DNA. Translation: CAD25388.1 .
RefSeqi NP_585784.1. NM_001041406.1.

3D structure databases

ProteinModelPortali Q8SRS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU06_0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859207.
KEGGi ecu:ECU06_0280.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU06_0280.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000149408.
InParanoidi Q8SRS8.
KOi K01869.
OMAi YSKFVEW.
OrthoDBi EOG7TTQH2.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiSYLC_ENCCU
AccessioniPrimary (citable) accession number: Q8SRS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3