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Q8SRS8

- SYLC_ENCCU

UniProt

Q8SRS8 - SYLC_ENCCU

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Protein
Probable leucine--tRNA ligase, cytoplasmic
Gene
ECU06_0280
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei547 – 5471ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. leucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tRNA aminoacylation for protein translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Ordered Locus Names:ECU06_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0280.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Probable leucine--tRNA ligase, cytoplasmic
PRO_0000388413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU06_0280.

Structurei

3D structure databases

ProteinModelPortaliQ8SRS8.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi36 – 4611"HIGH" region By similarity
Add
BLAST
Motifi544 – 5485"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000149408.
KOiK01869.
OMAiYSKFVEW.
OrthoDBiEOG7TTQH2.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRS8-1 [UniParc]FASTAAdd to Basket

« Hide

MEERSKLRYL SMLEVERDTI SDVSEKRKFF VTFTYPYMNG RLHLGHLFSI    50
SKADFFSYYK ELQGYNVLFP FSFHCTGMPI SASAKKLAEE LSGEKVDLSV 100
KKIIEDLGFD DVKPFTDPVH WVRTFPGLCE RSLKRFHGNI DWRRSFITTD 150
INKYYDSFIK WQFNRLNELG HLSFGKRHSI FCPVDKQPCL DHDRRKGENV 200
KPVGVVLCKL RFSEGILLAR IKQGCVPSKA VVGSRCDFIG FEYCNEKYFA 250
EKDVFENVDA QASGICVRES VKGDFFGGRR FSGFGKEVVC DAIEKDVPCV 300
VKGTQDKKDP SLAEYIKNEI ELISKVESTE TQLAETKDLL KFYEPEEEVI 350
SRSGGKCIVA LTDQWYINYC DPEWKKKVKR CIENLVCTDD TRAILEDGLE 400
WIGKWGFSRS FGLGTRIPWD SEYLIDSLSD STIYMAMYTF KHFLYRDLEG 450
KDELFPSNRL SDDVWNYIFL NRSITEDLAP YEEILSNCRE SFNYFYPIDL 500
RVGGKDLLKN HLIFFLFNHV ALFEEKHWPK RMFTNGHLML NSEKMSKSSG 550
NYMTVDESLD KFGVSSTRMC LAVCGDGNED ANFVESNANA FVLKLYSYVK 600
MIEELCTGRS LNPCILDLMK GYGEMGFADR FLMQTISMNV AHATRAHEDM 650
TYRDVVKYGF YEMVHAKEMY HILGGTNNEI LFLLCKAMTQ LLYPIIPSLA 700
RYLIETYFYS NFSLPVPFLS DTAEIDGVSY LKNTLKRLVA QKRRKKRCEV 750
VEILVGVEYS EWKRKCMSII DQIACECKVL NINVSEEMKT GESQFVPKII 800
DAVREVLKEF GIPEKKGILF SMDYLNHPEN YSVKFNEYEV LKAHKYYIEN 850
NTGLEVIVCV SPRADPGTPL FEFK 874
Length:874
Mass (Da):101,082
Last modified:June 1, 2002 - v1
Checksum:i2021A5BAFA798E90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590446 Genomic DNA. Translation: CAD25388.1.
RefSeqiNP_585784.1. NM_001041406.1.

Genome annotation databases

GeneIDi859207.
KEGGiecu:ECU06_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590446 Genomic DNA. Translation: CAD25388.1 .
RefSeqi NP_585784.1. NM_001041406.1.

3D structure databases

ProteinModelPortali Q8SRS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU06_0280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859207.
KEGGi ecu:ECU06_0280.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU06_0280.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000149408.
KOi K01869.
OMAi YSKFVEW.
OrthoDBi EOG7TTQH2.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiSYLC_ENCCU
AccessioniPrimary (citable) accession number: Q8SRS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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