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Protein

Probable leucine--tRNA ligase, cytoplasmic

Gene

ECU06_0280

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei547ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Ordered Locus Names:ECU06_0280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0280

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003884131 – 874Probable leucine--tRNA ligase, cytoplasmicAdd BLAST874

Proteomic databases

PRIDEiQ8SRS8

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_585784.1

Structurei

3D structure databases

ProteinModelPortaliQ8SRS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 46"HIGH" regionBy similarityAdd BLAST11
Motifi544 – 548"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0437 Eukaryota
COG0495 LUCA
HOGENOMiHOG000149408
InParanoidiQ8SRS8
KOiK01869
OrthoDBiEOG092C097K

Family and domain databases

Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 2 hits
PfamiView protein in Pfam
PF00133 tRNA-synt_1, 1 hit
PF09334 tRNA-synt_1g, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SRS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERSKLRYL SMLEVERDTI SDVSEKRKFF VTFTYPYMNG RLHLGHLFSI
60 70 80 90 100
SKADFFSYYK ELQGYNVLFP FSFHCTGMPI SASAKKLAEE LSGEKVDLSV
110 120 130 140 150
KKIIEDLGFD DVKPFTDPVH WVRTFPGLCE RSLKRFHGNI DWRRSFITTD
160 170 180 190 200
INKYYDSFIK WQFNRLNELG HLSFGKRHSI FCPVDKQPCL DHDRRKGENV
210 220 230 240 250
KPVGVVLCKL RFSEGILLAR IKQGCVPSKA VVGSRCDFIG FEYCNEKYFA
260 270 280 290 300
EKDVFENVDA QASGICVRES VKGDFFGGRR FSGFGKEVVC DAIEKDVPCV
310 320 330 340 350
VKGTQDKKDP SLAEYIKNEI ELISKVESTE TQLAETKDLL KFYEPEEEVI
360 370 380 390 400
SRSGGKCIVA LTDQWYINYC DPEWKKKVKR CIENLVCTDD TRAILEDGLE
410 420 430 440 450
WIGKWGFSRS FGLGTRIPWD SEYLIDSLSD STIYMAMYTF KHFLYRDLEG
460 470 480 490 500
KDELFPSNRL SDDVWNYIFL NRSITEDLAP YEEILSNCRE SFNYFYPIDL
510 520 530 540 550
RVGGKDLLKN HLIFFLFNHV ALFEEKHWPK RMFTNGHLML NSEKMSKSSG
560 570 580 590 600
NYMTVDESLD KFGVSSTRMC LAVCGDGNED ANFVESNANA FVLKLYSYVK
610 620 630 640 650
MIEELCTGRS LNPCILDLMK GYGEMGFADR FLMQTISMNV AHATRAHEDM
660 670 680 690 700
TYRDVVKYGF YEMVHAKEMY HILGGTNNEI LFLLCKAMTQ LLYPIIPSLA
710 720 730 740 750
RYLIETYFYS NFSLPVPFLS DTAEIDGVSY LKNTLKRLVA QKRRKKRCEV
760 770 780 790 800
VEILVGVEYS EWKRKCMSII DQIACECKVL NINVSEEMKT GESQFVPKII
810 820 830 840 850
DAVREVLKEF GIPEKKGILF SMDYLNHPEN YSVKFNEYEV LKAHKYYIEN
860 870
NTGLEVIVCV SPRADPGTPL FEFK
Length:874
Mass (Da):101,082
Last modified:June 1, 2002 - v1
Checksum:i2021A5BAFA798E90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590446 Genomic DNA Translation: CAD25388.1
RefSeqiNP_585784.1, NM_001041406.1

Genome annotation databases

EnsemblFungiiCAD25388; CAD25388; CAD25388
GeneIDi859207
KEGGiecu:ECU06_0280

Similar proteinsi

Entry informationi

Entry nameiSYLC_ENCCU
AccessioniPrimary (citable) accession number: Q8SRS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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