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Q8SRR2 (RIR2_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Ordered Locus Names:ECU06_0730
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length325 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small subunit By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 325325Ribonucleoside-diphosphate reductase small chain
PRO_0000190461

Sites

Active site1141 By similarity
Metal binding761Iron 1 By similarity
Metal binding1071Iron 1 By similarity
Metal binding1071Iron 2 By similarity
Metal binding1101Iron 1 By similarity
Metal binding1701Iron 2 By similarity
Metal binding2041Iron 2 By similarity
Metal binding2071Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SRR2 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 79814EA716494886

FASTA32537,987
        10         20         30         40         50         60 
MSHGEETELL LDPKEERFVL LPIKYHDIWK MYKKAESSFW TVEEVSLDKD IDDWGKLNAK 

        70         80         90        100        110        120 
ERHFISYVLA FFAASDGIVN LNLVERFSTE VKVLEARFFY GFQMAIENIH SEMYSLLIDT 

       130        140        150        160        170        180 
YIRDNDEKNF LFDAIRTIPS VKEKADWAIR WIEDKNSDFA TRLVAFACVE GIFFSGAFAS 

       190        200        210        220        230        240 
IFWLKKRGLM PGLTFSNELI SRDEGLHCEF ACLLHYHLKK KCNRIKEVVM DAVEIEKKFL 

       250        260        270        280        290        300 
SESLPVNLIG MNCNLMCRYI EFVADRLLEN LGEERVYNAT NPFDFMENIS LVGKTNFFDK 

       310        320 
RESQYQKAFV GIENGNDSFR IDVDF 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590446 Genomic DNA. Translation: CAD25433.1.
RefSeqNP_585829.1. NM_001041451.1.

3D structure databases

ProteinModelPortalQ8SRR2.
SMRQ8SRR2. Positions 6-287.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU06_0730.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859253.
KEGGecu:ECU06_0730.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU06_0730.

Phylogenomic databases

eggNOGCOG0208.
HOGENOMHOG000255975.
KOK10808.
OMATHEASFW.
OrthoDBEOG7T1RMH.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_ENCCU
AccessionPrimary (citable) accession number: Q8SRR2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways