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Q8SRR2

- RIR2_ENCCU

UniProt

Q8SRR2 - RIR2_ENCCU

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

ECU06_0730

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Iron 1PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron 1PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron 2By similarity
Metal bindingi110 – 1101Iron 1PROSITE-ProRule annotation
Active sitei114 – 1141PROSITE-ProRule annotation
Metal bindingi170 – 1701Iron 2By similarity
Metal bindingi204 – 2041Iron 2By similarity
Metal bindingi207 – 2071Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Ordered Locus Names:ECU06_0730
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU06_0730.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Ribonucleoside-diphosphate reductase small chainPRO_0000190461Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi6035.ECU06_0730.

Structurei

3D structure databases

ProteinModelPortaliQ8SRR2.
SMRiQ8SRR2. Positions 6-287.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0208.
HOGENOMiHOG000255975.
InParanoidiQ8SRR2.
KOiK10808.
OMAiTHEASFW.
OrthoDBiEOG7T1RMH.

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHGEETELL LDPKEERFVL LPIKYHDIWK MYKKAESSFW TVEEVSLDKD
60 70 80 90 100
IDDWGKLNAK ERHFISYVLA FFAASDGIVN LNLVERFSTE VKVLEARFFY
110 120 130 140 150
GFQMAIENIH SEMYSLLIDT YIRDNDEKNF LFDAIRTIPS VKEKADWAIR
160 170 180 190 200
WIEDKNSDFA TRLVAFACVE GIFFSGAFAS IFWLKKRGLM PGLTFSNELI
210 220 230 240 250
SRDEGLHCEF ACLLHYHLKK KCNRIKEVVM DAVEIEKKFL SESLPVNLIG
260 270 280 290 300
MNCNLMCRYI EFVADRLLEN LGEERVYNAT NPFDFMENIS LVGKTNFFDK
310 320
RESQYQKAFV GIENGNDSFR IDVDF
Length:325
Mass (Da):37,987
Last modified:June 1, 2002 - v1
Checksum:i79814EA716494886
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590446 Genomic DNA. Translation: CAD25433.1.
RefSeqiNP_585829.1. NM_001041451.1.

Genome annotation databases

GeneIDi859253.
KEGGiecu:ECU06_0730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590446 Genomic DNA. Translation: CAD25433.1 .
RefSeqi NP_585829.1. NM_001041451.1.

3D structure databases

ProteinModelPortali Q8SRR2.
SMRi Q8SRR2. Positions 6-287.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU06_0730.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859253.
KEGGi ecu:ECU06_0730.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU06_0730.

Phylogenomic databases

eggNOGi COG0208.
HOGENOMi HOG000255975.
InParanoidi Q8SRR2.
KOi K10808.
OMAi THEASFW.
OrthoDBi EOG7T1RMH.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiRIR2_ENCCU
AccessioniPrimary (citable) accession number: Q8SRR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3