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Q8SRR2

- RIR2_ENCCU

UniProt

Q8SRR2 - RIR2_ENCCU

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

ECU06_0730

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi76 – 761Iron 1PROSITE-ProRule annotation
    Metal bindingi107 – 1071Iron 1PROSITE-ProRule annotation
    Metal bindingi107 – 1071Iron 2By similarity
    Metal bindingi110 – 1101Iron 1PROSITE-ProRule annotation
    Active sitei114 – 1141PROSITE-ProRule annotation
    Metal bindingi170 – 1701Iron 2By similarity
    Metal bindingi204 – 2041Iron 2By similarity
    Metal bindingi207 – 2071Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Ordered Locus Names:ECU06_0730
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome VI

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU06_0730.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 325325Ribonucleoside-diphosphate reductase small chainPRO_0000190461Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of a large and a small subunit.By similarity

    Protein-protein interaction databases

    STRINGi6035.ECU06_0730.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SRR2.
    SMRiQ8SRR2. Positions 6-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0208.
    HOGENOMiHOG000255975.
    KOiK10808.
    OMAiTHEASFW.
    OrthoDBiEOG7T1RMH.

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SRR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHGEETELL LDPKEERFVL LPIKYHDIWK MYKKAESSFW TVEEVSLDKD    50
    IDDWGKLNAK ERHFISYVLA FFAASDGIVN LNLVERFSTE VKVLEARFFY 100
    GFQMAIENIH SEMYSLLIDT YIRDNDEKNF LFDAIRTIPS VKEKADWAIR 150
    WIEDKNSDFA TRLVAFACVE GIFFSGAFAS IFWLKKRGLM PGLTFSNELI 200
    SRDEGLHCEF ACLLHYHLKK KCNRIKEVVM DAVEIEKKFL SESLPVNLIG 250
    MNCNLMCRYI EFVADRLLEN LGEERVYNAT NPFDFMENIS LVGKTNFFDK 300
    RESQYQKAFV GIENGNDSFR IDVDF 325
    Length:325
    Mass (Da):37,987
    Last modified:June 1, 2002 - v1
    Checksum:i79814EA716494886
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590446 Genomic DNA. Translation: CAD25433.1.
    RefSeqiNP_585829.1. NM_001041451.1.

    Genome annotation databases

    GeneIDi859253.
    KEGGiecu:ECU06_0730.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590446 Genomic DNA. Translation: CAD25433.1 .
    RefSeqi NP_585829.1. NM_001041451.1.

    3D structure databases

    ProteinModelPortali Q8SRR2.
    SMRi Q8SRR2. Positions 6-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU06_0730.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859253.
    KEGGi ecu:ECU06_0730.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU06_0730.

    Phylogenomic databases

    eggNOGi COG0208.
    HOGENOMi HOG000255975.
    KOi K10808.
    OMAi THEASFW.
    OrthoDBi EOG7T1RMH.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.

    Entry informationi

    Entry nameiRIR2_ENCCU
    AccessioniPrimary (citable) accession number: Q8SRR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3