Q8SRK8 (KAPC_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cAMP-dependent protein kinase catalytic subunit
EC=2.7.11.11

Gene names

Ordered Locus Names:

ECU07_0520

Organism

Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

Taxonomic identifier

284813 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Microsporidia › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cAMP-dependent protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 322	322	Probable cAMP-dependent protein kinase catalytic subunit		PRO_0000086070
Regions
	Domain	7 – 261	255	Protein kinase
	Domain	262 – 322	61	AGC-kinase C-terminal
	Nucleotide binding	13 – 21	9	ATP By similarity
Sites
	Active site	132	1	Proton acceptor By similarity
	Binding site	37	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8SRK8 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: A6548FF96A4B4DE5	FASTA	322	36,415
	10 20 30 40 50 60 MLKIQDFEFV KVVGVGAFGK VHLVRLKSSP TSVFAMKMLD FGEILRQRLA DQLENEISIL 70 80 90 100 110 120 KRIYGCPFVA KLYSTDFHGG KVGLIMEYVG GGELFYWLKK CGRFDEQMAR FYAAEIISAL 130 140 150 160 170 180 RFIHGRGILY RDLKPENILI TSTGHIKLID FGFSVYESEN IYMISGTPEY MSPEKLRSED 190 200 210 220 230 240 DGRASDYWGL GVMIYEMLCG DPPFYDSSAD AIYHKILESN VVFPHYVSPV ARCLITGLLD 250 260 270 280 290 300 KNRATRLGTK GICEIMGHPF FKGIDWHEVE SRRIEPPFIP NPNTVLSSLA SSGELKGTDD 310 320 AETVVLKPYK HIKHLYKVSK GL

References

[1]

"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed: 11719806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590447 Genomic DNA. Translation: CAD25584.1.
RefSeq	NP_585980.1. NM_001041602.1.
3D structure databases
ProteinModelPortal	Q8SRK8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	859409.
GenomeReviews	Gene locus ECU07_0520 in contig AL590447_GR.
KEGG	ecu:ECU07_0520.
NMPDR	fig|6035.1.peg.883.
Organism-specific databases
EuPathDB	EupathDB:ECU07_0520.
Phylogenomic databases
eggNOG	fuNOG09673.
HOGENOM	HBG755340.
OMA	HEVESRR.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
KO	K04345.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAPC_ENCCU

Accession

Primary (citable) accession number: Q8SRK8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	June 1, 2002
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program