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Q8SRI2

- GFA1_ENCCU

UniProt

Q8SRI2 - GFA1_ENCCU

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
GFA1, ECU07_1280
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins) By similarity.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
  2. carbohydrate biosynthetic process Source: InterPro
  3. glutamine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00113; UER00528.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Short name:
GFAT
Alternative name(s):
D-fructose-6-phosphate amidotransferase
Hexosephosphate aminotransferase
Gene namesi
Name:GFA1
Ordered Locus Names:ECU07_1280
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU07_1280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 699698Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
PRO_0000381745Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU07_1280.

Structurei

3D structure databases

ProteinModelPortaliQ8SRI2.
SMRiQ8SRI2. Positions 339-687.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 303302Glutamine amidotransferase type-2
Add
BLAST
Domaini377 – 516140SIS 1
Add
BLAST
Domaini544 – 689146SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258898.
KOiK00820.
OMAiSAGICTL.
OrthoDBiEOG7034RG.

Family and domain databases

Gene3Di3.60.20.10. 2 hits.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 2 hits.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SRI2-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIFGYANF SKERSKDEIA NIMINGLKRI EYRGYDSAGF CITDNTDRNF    50
ARIRAVGKVN SLYEIKNSQT SVDLTRKVLN HVSIAHTRWA THGQPSIENS 100
HPLSSDENNS FLVVHNGIIT NYKDLKVYLK KKGFTFESDT DTECAAKLAL 150
YFYREMERKK EETDFVAIVK NVVKHCEGAF AFVFASSLFP NELVTVRKSS 200
PVLIGLKPSG KMSFDFFGVN YGDPADDTPT SLLDSPLAFS KSDRHGFDQN 250
IDMMTRDVQD CTLHAHNKEP LEVFVASDAS ALIEHTRKVI FLEDNDIVHI 300
SNGNISIHRM HSKAKESGPE IREVKTIETE LAAIMKGNYD HYMIKEINEQ 350
EESVVNTMRG RINFESLTVS LGGLKDHVSG IRKSQRIIFV ACGTSYHASL 400
ANRALLEELL EIPVSVEIAS DFLDRAPPIM RSDCVFFVSQ SGETADSVMA 450
LRYCMSMGAL CVGITNTVGS TISRETACGV HINAGPEIGV ASTKAYTSQY 500
IALVLVALQL SDQNLVKQAR RREIMEGLKN ISSQINRVLE LSTSVKSLAN 550
GPMKDDASLL LIGRGYQYPT CMEGALKIKE ITYIHAEGLA AGELKHGPIA 600
LVDDKLRIIF IATKDLLYDK TRNAMEQIFA RGGRPIVICT EDISGDYAEY 650
DTFVVPKTVD CLQGILTVIP LQLLSYHLAV AKGYNADFPR NLAKSVTVE 699
Length:699
Mass (Da):77,544
Last modified:June 1, 2002 - v1
Checksum:i225F2F74C19C6B36
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590447 Genomic DNA. Translation: CAD25661.1.
RefSeqiNP_586057.1. NM_001041679.1.

Genome annotation databases

GeneIDi859487.
KEGGiecu:ECU07_1280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590447 Genomic DNA. Translation: CAD25661.1 .
RefSeqi NP_586057.1. NM_001041679.1.

3D structure databases

ProteinModelPortali Q8SRI2.
SMRi Q8SRI2. Positions 339-687.
ModBasei Search...

Protein-protein interaction databases

STRINGi 6035.ECU07_1280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859487.
KEGGi ecu:ECU07_1280.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU07_1280.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258898.
KOi K00820.
OMAi SAGICTL.
OrthoDBi EOG7034RG.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .

Family and domain databases

Gene3Di 3.60.20.10. 2 hits.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 2 hits.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiGFA1_ENCCU
AccessioniPrimary (citable) accession number: Q8SRI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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