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Q8SRH6

- PSB6_ENCCU

UniProt

Q8SRH6 - PSB6_ENCCU

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Protein

Probable proteasome subunit beta type-6

Gene
PRE7, ECU07_1420
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-6 (EC:3.4.25.1)
Alternative name(s):
26S proteasome beta-type subunit PRE7
Multicatalytic endopeptidase complex subunit PRE7
Gene namesi
Name:PRE7
Ordered Locus Names:ECU07_1420
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU07_1420.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Probable proteasome subunit beta type-6PRO_0000382757Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Protein-protein interaction databases

STRINGi6035.ECU07_1420.

Structurei

3D structure databases

ProteinModelPortaliQ8SRH6.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000149343.
KOiK02732.
OMAiGIRINII.
OrthoDBiEOG7VMPGM.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRH6-1 [UniParc]FASTAAdd to Basket

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MLSNKRGIHS ASGGIDLRTL REYCLFEDFD VCMPFNPMGV PGGKGNRGSD    50
GAIRGMLPLG DAMGDLFTAG KAGSTKMEDK ERFDPYEDNS GTTICLKQGD 100
FIVVAGDTRH SSSMVINSRE MSKIFQVGDF LLTGTGFYAD THEVYVKMVY 150
EIRQYEVDDS INIHSAANLL SKILYSKRFF PYYSFCVLSG FEKGKPYVYS 200
YDPIGSFGSV TCVCSGSGRS MIQPLLDSFI DKKNWNNAEE TQLSQEDCIR 250
LVVKAFNSAA ERDVKTKDNL EVCVMRENQV MRETFPLRRD 290
Length:290
Mass (Da):32,454
Last modified:June 1, 2002 - v1
Checksum:i75C6A630EAFEA0D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590447 Genomic DNA. Translation: CAD25674.1.
RefSeqiNP_586070.1. NM_001041692.1.

Genome annotation databases

GeneIDi859500.
KEGGiecu:ECU07_1420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590447 Genomic DNA. Translation: CAD25674.1 .
RefSeqi NP_586070.1. NM_001041692.1.

3D structure databases

ProteinModelPortali Q8SRH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU07_1420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859500.
KEGGi ecu:ECU07_1420.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU07_1420.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000149343.
KOi K02732.
OMAi GIRINII.
OrthoDBi EOG7VMPGM.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPSB6_ENCCU
AccessioniPrimary (citable) accession number: Q8SRH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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