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Protein

Thymidylate synthase 3

Gene

TS-3

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

Pathwayi: dTTP biosynthesis

This protein is involved in the pathway dTTP biosynthesis, which is part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the pathway dTTP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei29dUMPBy similarity1
Active sitei174NucleophileBy similarity1
Binding sitei1975,10-methylenetetrahydrofolateBy similarity1
Binding sitei205dUMPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 155dUMP; shared with dimeric partnerBy similarity2
Nucleotide bindingi194 – 197dUMPBy similarity4
Nucleotide bindingi235 – 237dUMPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase 3 (EC:2.1.1.45)
Short name:
TS 3
Short name:
TSase 3
Gene namesi
Name:TS-3
Ordered Locus Names:ECU08_0090
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU08_0090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001409071 – 294Thymidylate synthase 3Add BLAST294

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_597138.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SRG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family.Curated

Phylogenomic databases

eggNOGiKOG0673. Eukaryota.
COG0207. LUCA.
HOGENOMiHOG000257899.
InParanoidiQ8SRG2.
KOiK00560.
OMAiPHKTIAM.
OrthoDBiEOG092C3QQ6.

Family and domain databases

CDDicd00351. TS_Pyrimidine_HMase. 1 hit.
Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact. 1 hit.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQDPRHPEH QYLDLVKHIL ENGARRMDRT GTGTLSVFGA TMRFSLEDNT
60 70 80 90 100
FPLLTTRRVF YRGVVEELLF FLRGETDSKV LEKKGVRIWE KNGAKQFLQS
110 120 130 140 150
VGIDREEGDL GPIYGFQWRH FGARYETSAS SYEGKGVDQI ASAIAAIRAN
160 170 180 190 200
PASRRIVVSA WNPTDLGSMA LPPCHVLFQF NVTDGKLSCA MYQRSGDMGL
210 220 230 240 250
GVPFNIASYS LLTILVAHLT GLQPGEFVHF LGDAHVYLDH VDSLRQQVQR
260 270 280 290
PPRAFPKLFV SPKGPRTEPE HFQYEDFELV GYDPHPAIKM NMSA
Length:294
Mass (Da):33,098
Last modified:June 1, 2002 - v1
Checksum:iB2521707E86C157E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26314.1.
RefSeqiNP_597138.1. NM_001041747.1.

Genome annotation databases

EnsemblFungiiCAD26314; CAD26314; CAD26314.
GeneIDi859560.
KEGGiecu:ECU08_0090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26314.1.
RefSeqiNP_597138.1. NM_001041747.1.

3D structure databases

ProteinModelPortaliQ8SRG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284813.NP_597138.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAD26314; CAD26314; CAD26314.
GeneIDi859560.
KEGGiecu:ECU08_0090.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU08_0090.

Phylogenomic databases

eggNOGiKOG0673. Eukaryota.
COG0207. LUCA.
HOGENOMiHOG000257899.
InParanoidiQ8SRG2.
KOiK00560.
OMAiPHKTIAM.
OrthoDBiEOG092C3QQ6.

Enzyme and pathway databases

UniPathwayiUPA00575.

Family and domain databases

CDDicd00351. TS_Pyrimidine_HMase. 1 hit.
Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact. 1 hit.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYS3_ENCCU
AccessioniPrimary (citable) accession number: Q8SRG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 1, 2002
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.