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Q8SRF5 (Y823_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cell division protein kinase ECU08_0230

EC=2.7.11.22
Gene names
Ordered Locus Names:ECU08_0230
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a role in the control of the eukaryotic cell cycle By similarity. Ref.2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentNucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Probable cell division protein kinase ECU08_0230
PRO_0000385505

Regions

Domain4 – 263260Protein kinase
Nucleotide binding10 – 189ATP By similarity

Sites

Active site1211Proton acceptor By similarity
Binding site331ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SRF5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 18E742DF03CB56D1

FASTA26530,400
        10         20         30         40         50         60 
MTRYILGALI GSGTYGEVYE AIDTETKEKV ALKRIRLNEK EGMPGTALRE ISILKKLSHR 

        70         80         90        100        110        120 
NIISLVSIIH TDALLTMVFP FIDYELKKYI GMNTGKNIME LVNQLICGVH YLHRMNVVHR 

       130        140        150        160        170        180 
DLKPQNILVT SDGVLKIADF GLSRSLEIRV PPYSSEVVTL WYRSPELLMG STSYRFYVDI 

       190        200        210        220        230        240 
WSLGCIIYEM ITLEPLFPGE SKENQLTLIR RKAGTRRSLR GMVEQRLAVP KFVTEIIVRC 

       250        260 
LDFNYNQRIT ADEIMEILEN EYGAC 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J.
BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PREDICTION OF FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590448 Genomic DNA. Translation: CAD26328.1.
RefSeqNP_597152.1. NM_001041761.1.

3D structure databases

ProteinModelPortalQ8SRF5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU08_0230.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859574.
KEGGecu:ECU08_0230.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU08_0230.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
OMALDECGGE.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameY823_ENCCU
AccessionPrimary (citable) accession number: Q8SRF5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families