Q8SRF5 (Y823_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cell division protein kinase ECU08_0230
EC=2.7.11.22

Gene names

Ordered Locus Names:

ECU08_0230

Organism

Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]

Taxonomic identifier

284813 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Microsporidia › Apansporoblastina › Unikaryonidae › Encephalitozoon › Encephalitozoon cuniculi

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in the control of the eukaryotic cell cycle By similarity. Ref.2
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cyclin-dependent protein serine/threonine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Probable cell division protein kinase ECU08_0230		PRO_0000385505
Regions
	Domain	4 – 263	260	Protein kinase
	Nucleotide binding	10 – 18	9	ATP By similarity
Sites
	Active site	121	1	Proton acceptor By similarity
	Binding site	33	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8SRF5 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 18E742DF03CB56D1	FASTA	265	30,400
	10 20 30 40 50 60 MTRYILGALI GSGTYGEVYE AIDTETKEKV ALKRIRLNEK EGMPGTALRE ISILKKLSHR 70 80 90 100 110 120 NIISLVSIIH TDALLTMVFP FIDYELKKYI GMNTGKNIME LVNQLICGVH YLHRMNVVHR 130 140 150 160 170 180 DLKPQNILVT SDGVLKIADF GLSRSLEIRV PPYSSEVVTL WYRSPELLMG STSYRFYVDI 190 200 210 220 230 240 WSLGCIIYEM ITLEPLFPGE SKENQLTLIR RKAGTRRSLR GMVEQRLAVP KFVTEIIVRC 250 260 LDFNYNQRIT ADEIMEILEN EYGAC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[2]	"The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe." Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J. BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PREDICTION OF FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590448 Genomic DNA. Translation: CAD26328.1.
RefSeq	NP_597152.1. NM_001041761.1.
3D structure databases
HSSP	HSSP built from PDB template 1OIQ based on UniProtKB P24941.
ProteinModelPortal	Q8SRF5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	859574.
KEGG	ecu:ECU08_0230.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233024.
OMA	TIHTERS.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y823_ENCCU

Accession

Primary (citable) accession number: Q8SRF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program