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Q8SRF5

- Y823_ENCCU

UniProt

Q8SRF5 - Y823_ENCCU

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Protein

Probable cell division protein kinase ECU08_0230

Gene

ECU08_0230

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

May play a role in the control of the eukaryotic cell cycle.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei121 – 1211Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cell division protein kinase ECU08_0230 (EC:2.7.11.22)
Gene namesi
Ordered Locus Names:ECU08_0230
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VIII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU08_0230.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Probable cell division protein kinase ECU08_0230PRO_0000385505Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU08_0230.

Structurei

3D structure databases

ProteinModelPortaliQ8SRF5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 263260Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ8SRF5.
OMAiLDECGGE.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRYILGALI GSGTYGEVYE AIDTETKEKV ALKRIRLNEK EGMPGTALRE
60 70 80 90 100
ISILKKLSHR NIISLVSIIH TDALLTMVFP FIDYELKKYI GMNTGKNIME
110 120 130 140 150
LVNQLICGVH YLHRMNVVHR DLKPQNILVT SDGVLKIADF GLSRSLEIRV
160 170 180 190 200
PPYSSEVVTL WYRSPELLMG STSYRFYVDI WSLGCIIYEM ITLEPLFPGE
210 220 230 240 250
SKENQLTLIR RKAGTRRSLR GMVEQRLAVP KFVTEIIVRC LDFNYNQRIT
260
ADEIMEILEN EYGAC
Length:265
Mass (Da):30,400
Last modified:June 1, 2002 - v1
Checksum:i18E742DF03CB56D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26328.1.
RefSeqiNP_597152.1. NM_001041761.1.

Genome annotation databases

GeneIDi859574.
KEGGiecu:ECU08_0230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26328.1 .
RefSeqi NP_597152.1. NM_001041761.1.

3D structure databases

ProteinModelPortali Q8SRF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU08_0230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859574.
KEGGi ecu:ECU08_0230.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU08_0230.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q8SRF5.
OMAi LDECGGE.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J.
    BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF FUNCTION.

Entry informationi

Entry nameiY823_ENCCU
AccessioniPrimary (citable) accession number: Q8SRF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3