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Q8SRF5

- Y823_ENCCU

UniProt

Q8SRF5 - Y823_ENCCU

Protein

Probable cell division protein kinase ECU08_0230

Gene

ECU08_0230

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    May play a role in the control of the eukaryotic cell cycle.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei121 – 1211Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cell division protein kinase ECU08_0230 (EC:2.7.11.22)
    Gene namesi
    Ordered Locus Names:ECU08_0230
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome VIII

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU08_0230.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Probable cell division protein kinase ECU08_0230PRO_0000385505Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU08_0230.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SRF5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 263260Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    OMAiLDECGGE.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SRF5-1 [UniParc]FASTAAdd to Basket

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    MTRYILGALI GSGTYGEVYE AIDTETKEKV ALKRIRLNEK EGMPGTALRE    50
    ISILKKLSHR NIISLVSIIH TDALLTMVFP FIDYELKKYI GMNTGKNIME 100
    LVNQLICGVH YLHRMNVVHR DLKPQNILVT SDGVLKIADF GLSRSLEIRV 150
    PPYSSEVVTL WYRSPELLMG STSYRFYVDI WSLGCIIYEM ITLEPLFPGE 200
    SKENQLTLIR RKAGTRRSLR GMVEQRLAVP KFVTEIIVRC LDFNYNQRIT 250
    ADEIMEILEN EYGAC 265
    Length:265
    Mass (Da):30,400
    Last modified:June 1, 2002 - v1
    Checksum:i18E742DF03CB56D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590448 Genomic DNA. Translation: CAD26328.1.
    RefSeqiNP_597152.1. NM_001041761.1.

    Genome annotation databases

    GeneIDi859574.
    KEGGiecu:ECU08_0230.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590448 Genomic DNA. Translation: CAD26328.1 .
    RefSeqi NP_597152.1. NM_001041761.1.

    3D structure databases

    ProteinModelPortali Q8SRF5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU08_0230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859574.
    KEGGi ecu:ECU08_0230.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU08_0230.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    OMAi LDECGGE.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
      Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J.
      BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PREDICTION OF FUNCTION.

    Entry informationi

    Entry nameiY823_ENCCU
    AccessioniPrimary (citable) accession number: Q8SRF5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3