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Protein

Arginine--tRNA ligase

Gene

ECU08_0550

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Ordered Locus Names:ECU08_0550
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU08_0550.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003831421 – 563Arginine--tRNA ligaseAdd BLAST563

Proteomic databases

PRIDEiQ8SRD8.

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi284813.NP_597184.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SRD8.
SMRiQ8SRD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1195. Eukaryota.
COG0018. LUCA.
HOGENOMiHOG000247211.
InParanoidiQ8SRD8.
KOiK01887.
OMAiHVKFGRI.
OrthoDBiEOG092C0Z3M.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SRD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNELFRKVV EAISKASKFT PEEIAACMER SYQPKKPNVT LFLDRISPSP
60 70 80 90 100
QEDAKELLET LAGANIELIE NLAIRKSSVC CDINKRAILK DVLGYIQKNR
110 120 130 140 150
EIFGNNNVGK GKRMVVEYSS PNIAKIFHIG HLRTTVLGQF IVNLLRASGY
160 170 180 190 200
ETTSINYFGD WGKQFGFVLL GYSKYGSEEE LEKDPLKHLF NVYVKISADA
210 220 230 240 250
EKNPDVDSEA KEIFRMMEED KDEWCMNLWR RFRELSIEKY KVLYKRLNVE
260 270 280 290 300
FDVYSGESMY NEKGKSIVET SKQIKTDEDG SKVFDLGKAG KVLVMKNDGT
310 320 330 340 350
TLYITRDIAA AIERLEEYSP EKIIYVVSSE QNKHFEDLFG VLEMLGYDKD
360 370 380 390 400
KFQHVSYGLV AGMSTRAGKV QLLEDIIQES TEVMKNVMMS DNNKGSFTAA
410 420 430 440 450
EMDQTAEVLA ISTLLVMDFT ARRVKGYEFD IEKRARNTSG TGLYLQYAHC
460 470 480 490 500
RLRSIETKNS NVDYNDIETI DFELIHVPKV LNLVYKLLWF EHVVEKCLED
510 520 530 540 550
YEPSRIVTYL QDLASSINGA INILRVLGVD KELARARLLV LSSARIVLHN
560
GLRILGATPL NKM
Length:563
Mass (Da):64,253
Last modified:June 1, 2002 - v1
Checksum:iF6E50A60D4D4BB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26360.1.
RefSeqiNP_597184.1. NM_001041793.1.

Genome annotation databases

EnsemblFungiiCAD26360; CAD26360; CAD26360.
GeneIDi859606.
KEGGiecu:ECU08_0550.

Similar proteinsi

Entry informationi

Entry nameiSYR_ENCCU
AccessioniPrimary (citable) accession number: Q8SRD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families