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Q8SRD8

- SYR_ENCCU

UniProt

Q8SRD8 - SYR_ENCCU

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Protein

Arginine--tRNA ligase

Gene

ECU08_0550

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Ordered Locus Names:ECU08_0550
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome VIII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU08_0550.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Arginine--tRNA ligasePRO_0000383142Add
BLAST

Proteomic databases

PRIDEiQ8SRD8.

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi6035.ECU08_0550.

Structurei

3D structure databases

ProteinModelPortaliQ8SRD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247211.
InParanoidiQ8SRD8.
KOiK01887.
OMAiCEDRGAL.
OrthoDBiEOG7NKKV8.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SRD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFNELFRKVV EAISKASKFT PEEIAACMER SYQPKKPNVT LFLDRISPSP
60 70 80 90 100
QEDAKELLET LAGANIELIE NLAIRKSSVC CDINKRAILK DVLGYIQKNR
110 120 130 140 150
EIFGNNNVGK GKRMVVEYSS PNIAKIFHIG HLRTTVLGQF IVNLLRASGY
160 170 180 190 200
ETTSINYFGD WGKQFGFVLL GYSKYGSEEE LEKDPLKHLF NVYVKISADA
210 220 230 240 250
EKNPDVDSEA KEIFRMMEED KDEWCMNLWR RFRELSIEKY KVLYKRLNVE
260 270 280 290 300
FDVYSGESMY NEKGKSIVET SKQIKTDEDG SKVFDLGKAG KVLVMKNDGT
310 320 330 340 350
TLYITRDIAA AIERLEEYSP EKIIYVVSSE QNKHFEDLFG VLEMLGYDKD
360 370 380 390 400
KFQHVSYGLV AGMSTRAGKV QLLEDIIQES TEVMKNVMMS DNNKGSFTAA
410 420 430 440 450
EMDQTAEVLA ISTLLVMDFT ARRVKGYEFD IEKRARNTSG TGLYLQYAHC
460 470 480 490 500
RLRSIETKNS NVDYNDIETI DFELIHVPKV LNLVYKLLWF EHVVEKCLED
510 520 530 540 550
YEPSRIVTYL QDLASSINGA INILRVLGVD KELARARLLV LSSARIVLHN
560
GLRILGATPL NKM
Length:563
Mass (Da):64,253
Last modified:June 1, 2002 - v1
Checksum:iF6E50A60D4D4BB50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26360.1.
RefSeqiNP_597184.1. NM_001041793.1.

Genome annotation databases

GeneIDi859606.
KEGGiecu:ECU08_0550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA. Translation: CAD26360.1 .
RefSeqi NP_597184.1. NM_001041793.1.

3D structure databases

ProteinModelPortali Q8SRD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU08_0550.

Proteomic databases

PRIDEi Q8SRD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859606.
KEGGi ecu:ECU08_0550.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU08_0550.

Phylogenomic databases

eggNOGi COG0018.
HOGENOMi HOG000247211.
InParanoidi Q8SRD8.
KOi K01887.
OMAi CEDRGAL.
OrthoDBi EOG7NKKV8.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR11956. PTHR11956. 1 hit.
Pfami PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view ]
PRINTSi PR01038. TRNASYNTHARG.
SMARTi SM00836. DALR_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00456. argS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSYR_ENCCU
AccessioniPrimary (citable) accession number: Q8SRD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3