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Q8SRD8 (SYR_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Ordered Locus Names:ECU08_0550
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length563 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

Subunit structure

Monomer By similarity.

Developmental stage

Expressed in late sporogonial stages.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 563563Arginine--tRNA ligase
PRO_0000383142

Sequences

Sequence LengthMass (Da)Tools
Q8SRD8 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: F6E50A60D4D4BB50

FASTA56364,253
        10         20         30         40         50         60 
MFNELFRKVV EAISKASKFT PEEIAACMER SYQPKKPNVT LFLDRISPSP QEDAKELLET 

        70         80         90        100        110        120 
LAGANIELIE NLAIRKSSVC CDINKRAILK DVLGYIQKNR EIFGNNNVGK GKRMVVEYSS 

       130        140        150        160        170        180 
PNIAKIFHIG HLRTTVLGQF IVNLLRASGY ETTSINYFGD WGKQFGFVLL GYSKYGSEEE 

       190        200        210        220        230        240 
LEKDPLKHLF NVYVKISADA EKNPDVDSEA KEIFRMMEED KDEWCMNLWR RFRELSIEKY 

       250        260        270        280        290        300 
KVLYKRLNVE FDVYSGESMY NEKGKSIVET SKQIKTDEDG SKVFDLGKAG KVLVMKNDGT 

       310        320        330        340        350        360 
TLYITRDIAA AIERLEEYSP EKIIYVVSSE QNKHFEDLFG VLEMLGYDKD KFQHVSYGLV 

       370        380        390        400        410        420 
AGMSTRAGKV QLLEDIIQES TEVMKNVMMS DNNKGSFTAA EMDQTAEVLA ISTLLVMDFT 

       430        440        450        460        470        480 
ARRVKGYEFD IEKRARNTSG TGLYLQYAHC RLRSIETKNS NVDYNDIETI DFELIHVPKV 

       490        500        510        520        530        540 
LNLVYKLLWF EHVVEKCLED YEPSRIVTYL QDLASSINGA INILRVLGVD KELARARLLV 

       550        560 
LSSARIVLHN GLRILGATPL NKM 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590448 Genomic DNA. Translation: CAD26360.1.
RefSeqNP_597184.1. NM_001041793.1.

3D structure databases

ProteinModelPortalQ8SRD8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU08_0550.

Proteomic databases

PRIDEQ8SRD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859606.
KEGGecu:ECU08_0550.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU08_0550.

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247211.
KOK01887.
OMACEDRGAL.
OrthoDBEOG7NKKV8.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_ENCCU
AccessionPrimary (citable) accession number: Q8SRD8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries