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Q8SR89

- G6PD_ENCCU

UniProt

Q8SR89 - G6PD_ENCCU

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZWF1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361NADPBy similarity
    Binding sitei112 – 1121NADP; via carbonyl oxygenBy similarity
    Binding sitei112 – 1121SubstrateBy similarity
    Binding sitei175 – 1751SubstrateBy similarity
    Binding sitei193 – 1931SubstrateBy similarity
    Active sitei198 – 1981Proton acceptorBy similarity
    Binding sitei280 – 2801SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 148NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:ZWF1
    Ordered Locus Names:ECU08_1850
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome VIII

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU08_1850.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 434434Glucose-6-phosphate 1-dehydrogenasePRO_0000381752Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in late sporogonial stages.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU08_1850.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SR89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1415Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000149291.
    KOiK00036.
    OMAiTHLFQVA.
    OrthoDBiEOG7TXKRP.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.

    Sequencei

    Sequence statusi: Complete.

    Q8SR89-1 [UniParc]FASTAAdd to Basket

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    MKVVIFGSSG DLAKRKLFPA LSRIDLEGVG VVGYARTKYN IEFSEVLQEV    50
    GNYSPEFLSK VTYIPGPYDD LSKLKEVSDS ETVLYFSVPS SVYTCLFREI 100
    SKLDYKVIGV EKPYGDSIES FMEIKGFDLG KTRFIDHYLL KPLVVAMPGI 150
    IRETGAIREV MSNRYVKSVE IVSKEVLGGE GRHYFDKNGI IRDMVLSHMG 200
    ELLGVVASDV TKPSRIMEAL ARMEVFKACT VDTERCIYGQ YDDYIKEIHK 250
    DSSTETFCMV PISIGTPRWS KVPFIIVAGK GMNEKRTEII LEFRRDVFAK 300
    CIELFSMPRQ SSCRIVHTNE IETVRLVFNI YPECEVFLEV LVGGEPVRYV 350
    LHDKKEIDGL MHDSYGGYHD YEIIFDSLVR GKDFSSVSSQ EAELLWKVFN 400
    PILSISKEDM LFYYSKGIDM PKEAEEMIRE IKDH 434
    Length:434
    Mass (Da):49,544
    Last modified:June 1, 2002 - v1
    Checksum:i0FD1BE2052CF0D45
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590448 Genomic DNA. Translation: CAD26488.1.
    RefSeqiNP_597312.1. NM_001041921.1.

    Genome annotation databases

    GeneIDi859734.
    KEGGiecu:ECU08_1850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590448 Genomic DNA. Translation: CAD26488.1 .
    RefSeqi NP_597312.1. NM_001041921.1.

    3D structure databases

    ProteinModelPortali Q8SR89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU08_1850.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859734.
    KEGGi ecu:ECU08_1850.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU08_1850.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000149291.
    KOi K00036.
    OMAi THLFQVA.
    OrthoDBi EOG7TXKRP.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
      Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
      Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiG6PD_ENCCU
    AccessioniPrimary (citable) accession number: Q8SR89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3