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Q8SR89 (G6PD_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate 1-dehydrogenase

Short name=G6PD
EC=1.1.1.49
Gene names
Name:ZWF1
Ordered Locus Names:ECU08_1850
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity. HAMAP-Rule MF_00966

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH. HAMAP-Rule MF_00966

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. HAMAP-Rule MF_00966

Developmental stage

Expressed in late sporogonial stages. HAMAP-Rule MF_00966

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Glucose-6-phosphate 1-dehydrogenase HAMAP-Rule MF_00966
PRO_0000381752

Regions

Nucleotide binding7 – 148NADP By similarity
Region137 – 1415Substrate binding By similarity

Sites

Active site1981Proton acceptor By similarity
Binding site361NADP By similarity
Binding site1121NADP; via carbonyl oxygen By similarity
Binding site1121Substrate By similarity
Binding site1751Substrate By similarity
Binding site1931Substrate By similarity
Binding site2801Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SR89 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 0FD1BE2052CF0D45

FASTA43449,544
        10         20         30         40         50         60 
MKVVIFGSSG DLAKRKLFPA LSRIDLEGVG VVGYARTKYN IEFSEVLQEV GNYSPEFLSK 

        70         80         90        100        110        120 
VTYIPGPYDD LSKLKEVSDS ETVLYFSVPS SVYTCLFREI SKLDYKVIGV EKPYGDSIES 

       130        140        150        160        170        180 
FMEIKGFDLG KTRFIDHYLL KPLVVAMPGI IRETGAIREV MSNRYVKSVE IVSKEVLGGE 

       190        200        210        220        230        240 
GRHYFDKNGI IRDMVLSHMG ELLGVVASDV TKPSRIMEAL ARMEVFKACT VDTERCIYGQ 

       250        260        270        280        290        300 
YDDYIKEIHK DSSTETFCMV PISIGTPRWS KVPFIIVAGK GMNEKRTEII LEFRRDVFAK 

       310        320        330        340        350        360 
CIELFSMPRQ SSCRIVHTNE IETVRLVFNI YPECEVFLEV LVGGEPVRYV LHDKKEIDGL 

       370        380        390        400        410        420 
MHDSYGGYHD YEIIFDSLVR GKDFSSVSSQ EAELLWKVFN PILSISKEDM LFYYSKGIDM 

       430 
PKEAEEMIRE IKDH 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590448 Genomic DNA. Translation: CAD26488.1.
RefSeqNP_597312.1. NM_001041921.1.

3D structure databases

ProteinModelPortalQ8SR89.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU08_1850.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859734.
KEGGecu:ECU08_1850.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU08_1850.

Phylogenomic databases

eggNOGCOG0364.
HOGENOMHOG000149291.
KOK00036.
OMATHLFQVA.
OrthoDBEOG7TXKRP.

Enzyme and pathway databases

UniPathwayUPA00115; UER00408.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00966. G6PD.
InterProIPR001282. G6P_DH.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23429. PTHR23429. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
ProtoNetSearch...

Entry information

Entry nameG6PD_ENCCU
AccessionPrimary (citable) accession number: Q8SR89
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways