Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

ZWF1

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (ZWF1)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (ECU05_0860)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADPBy similarity1
Binding sitei112NADP; via carbonyl oxygenBy similarity1
Binding sitei112SubstrateBy similarity1
Binding sitei175SubstrateBy similarity1
Binding sitei193SubstrateBy similarity1
Active sitei198Proton acceptorBy similarity1
Binding sitei280SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:ZWF1
Ordered Locus Names:ECU08_1850
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome VIII

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU08_1850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003817521 – 434Glucose-6-phosphate 1-dehydrogenaseAdd BLAST434

Proteomic databases

PRIDEiQ8SR89

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_597312.1

Structurei

3D structure databases

ProteinModelPortaliQ8SR89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 141Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0563 Eukaryota
COG0364 LUCA
HOGENOMiHOG000149291
InParanoidiQ8SR89
KOiK00036
OMAiSETHPPV
OrthoDBiEOG092C2MOH

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SR89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVIFGSSG DLAKRKLFPA LSRIDLEGVG VVGYARTKYN IEFSEVLQEV
60 70 80 90 100
GNYSPEFLSK VTYIPGPYDD LSKLKEVSDS ETVLYFSVPS SVYTCLFREI
110 120 130 140 150
SKLDYKVIGV EKPYGDSIES FMEIKGFDLG KTRFIDHYLL KPLVVAMPGI
160 170 180 190 200
IRETGAIREV MSNRYVKSVE IVSKEVLGGE GRHYFDKNGI IRDMVLSHMG
210 220 230 240 250
ELLGVVASDV TKPSRIMEAL ARMEVFKACT VDTERCIYGQ YDDYIKEIHK
260 270 280 290 300
DSSTETFCMV PISIGTPRWS KVPFIIVAGK GMNEKRTEII LEFRRDVFAK
310 320 330 340 350
CIELFSMPRQ SSCRIVHTNE IETVRLVFNI YPECEVFLEV LVGGEPVRYV
360 370 380 390 400
LHDKKEIDGL MHDSYGGYHD YEIIFDSLVR GKDFSSVSSQ EAELLWKVFN
410 420 430
PILSISKEDM LFYYSKGIDM PKEAEEMIRE IKDH
Length:434
Mass (Da):49,544
Last modified:June 1, 2002 - v1
Checksum:i0FD1BE2052CF0D45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590448 Genomic DNA Translation: CAD26488.1
RefSeqiNP_597312.1, NM_001041921.1

Genome annotation databases

EnsemblFungiiCAD26488; CAD26488; CAD26488
GeneIDi859734
KEGGiecu:ECU08_1850

Similar proteinsi

Entry informationi

Entry nameiG6PD_ENCCU
AccessioniPrimary (citable) accession number: Q8SR89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health