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Q8SR86

- CDK1_ENCCU

UniProt

Q8SR86 - CDK1_ENCCU

Protein

Cyclin-dependent kinase 1

Gene

CDC28

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei34 – 341ATPPROSITE-ProRule annotation
    Active sitei130 – 1301Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase 1
    Short name:
    CDK1
    Alternative name(s):
    Cell division control protein 28 homolog (EC:2.7.11.22)
    Cell division protein kinase 1
    Gene namesi
    Name:CDC28
    Synonyms:CDK1
    Ordered Locus Names:ECU08_1920
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome VIII

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU08_1920.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Cyclin-dependent kinase 1PRO_0000385503Add
    BLAST

    Proteomic databases

    PRIDEiQ8SR86.

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU08_1920.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SR86.
    SMRiQ8SR86. Positions 3-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini5 – 288284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    KOiK02206.
    OMAiRGIKHCH.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SR86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTESFQKLEK IGEGTYGVVY KARERNTNRV VALKKIRLEN ENEGIPATTI    50
    REILLLKNLK HSTIVELSDV IYNNNKMYLV FEYVELDLRR YLDRMSDEGR 100
    LVEEGFVRKM SQQLLTAMEY CHSRNIFHRD LKPQNILVDP KENIKLADFG 150
    LGRAAGIPLR TYTTEVVTLW YRPPELLLGC KYYDASVDVW SAACIMAEVV 200
    LMRPFFPGDS EIDQLFRIFK VLGTPNNSRW SNVENFPNYK VEFPVWDPVD 250
    LKTIFRGDPD FVDLISKMLE YDPKMRMTAK NGLSHKYFEG MPLIME 296
    Length:296
    Mass (Da):34,530
    Last modified:June 1, 2002 - v1
    Checksum:i053464C6D57A7359
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590448 Genomic DNA. Translation: CAD26495.1.
    RefSeqiNP_597319.1. NM_001041928.1.

    Genome annotation databases

    GeneIDi859741.
    KEGGiecu:ECU08_1920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590448 Genomic DNA. Translation: CAD26495.1 .
    RefSeqi NP_597319.1. NM_001041928.1.

    3D structure databases

    ProteinModelPortali Q8SR86.
    SMRi Q8SR86. Positions 3-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU08_1920.

    Proteomic databases

    PRIDEi Q8SR86.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859741.
    KEGGi ecu:ECU08_1920.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU08_1920.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    KOi K02206.
    OMAi RGIKHCH.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
      Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J.
      BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PREDICTION OF FUNCTION.

    Entry informationi

    Entry nameiCDK1_ENCCU
    AccessioniPrimary (citable) accession number: Q8SR86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3