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Q8SR86 (CDK1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 1

Short name=CDK1
Alternative name(s):
Cell division control protein 28 homolog
EC=2.7.11.22
Cell division protein kinase 1
Gene names
Name:CDC28
Synonyms:CDK1
Ordered Locus Names:ECU08_1920
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis By similarity. Ref.2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processCell cycle
Cell division
Mitosis
   Cellular componentNucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmitotic nuclear division

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cyclin-dependent protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Cyclin-dependent kinase 1
PRO_0000385503

Regions

Domain5 – 288284Protein kinase
Nucleotide binding11 – 199ATP By similarity

Sites

Active site1301Proton acceptor By similarity
Binding site341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SR86 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 053464C6D57A7359

FASTA29634,530
        10         20         30         40         50         60 
MTESFQKLEK IGEGTYGVVY KARERNTNRV VALKKIRLEN ENEGIPATTI REILLLKNLK 

        70         80         90        100        110        120 
HSTIVELSDV IYNNNKMYLV FEYVELDLRR YLDRMSDEGR LVEEGFVRKM SQQLLTAMEY 

       130        140        150        160        170        180 
CHSRNIFHRD LKPQNILVDP KENIKLADFG LGRAAGIPLR TYTTEVVTLW YRPPELLLGC 

       190        200        210        220        230        240 
KYYDASVDVW SAACIMAEVV LMRPFFPGDS EIDQLFRIFK VLGTPNNSRW SNVENFPNYK 

       250        260        270        280        290 
VEFPVWDPVD LKTIFRGDPD FVDLISKMLE YDPKMRMTAK NGLSHKYFEG MPLIME 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J.
BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PREDICTION OF FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590448 Genomic DNA. Translation: CAD26495.1.
RefSeqNP_597319.1. NM_001041928.1.

3D structure databases

ProteinModelPortalQ8SR86.
SMRQ8SR86. Positions 3-289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU08_1920.

Proteomic databases

PRIDEQ8SR86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859741.
KEGGecu:ECU08_1920.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU08_1920.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK02206.
OMARGIKHCH.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK1_ENCCU
AccessionPrimary (citable) accession number: Q8SR86
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: June 1, 2002
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families