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Protein

Probable phosphatidylinositol 3-kinase VPS34 homolog

Gene

VPS34

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processProtein transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 3-kinase VPS34 homolog (EC:2.7.1.137)
Short name:
PI3-kinase VPS34
Short name:
PI3K VPS34
Short name:
PtdIns-3-kinase VPS34
Gene namesi
Name:VPS34
Ordered Locus Names:ECU10_0590
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome X

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0590.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003884381 – 446Probable phosphatidylinositol 3-kinase VPS34 homologAdd BLAST446

Interactioni

Subunit structurei

Component of the autophagy-specific VPS34 PI3-kinase complex I composed; and of the VPS34 PI3-kinase complex II.By similarity

Protein-protein interaction databases

STRINGi284813.NP_586174.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SR56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 444PI3K/PI4KPROSITE-ProRule annotationAdd BLAST243

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Phylogenomic databases

eggNOGiKOG0906. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000149280.
InParanoidiQ8SR56.
OrthoDBiEOG093100GK.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR015433. PI_Kinase.
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiView protein in Pfam
PF00454. PI3_PI4_kinase. 1 hit.
SMARTiView protein in SMART
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50290. PI3_4_KINASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SR56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEWDGDVFT WNAGKEDIYT LIESILRLLK NGCKGMENMV VKYLGTGATD
60 70 80 90 100
SLYMYFPWLR GRDLESRLSV EHQIDRFWKI RFELHEERTN SMDRYEDIVS
110 120 130 140 150
SFLALDTKCG ILGKLEGQMA LVDEIRRIYS ITSQGSPRKK RLREYRLHGT
160 170 180 190 200
LCLHPGAGSM RLYASLFSLD ATVKEIIFPE IEIFPSSTFP ILVPLRTDRG
210 220 230 240 250
VSRIIYKKGD DLTRDLFVLE TIRYMSRLMG VDLVTYKVIP LSRKEGIVEV
260 270 280 290 300
VDGIDFTRIR SRKDLEMYIE EDRDPRHQES FEKRKVFVST LCGYSVACYV
310 320 330 340 350
MGIGDRNPGN MMVTRDGKFF HIDFSHVFGR DPKPISSRIT IARPIRDYLV
360 370 380 390 400
NDELIYQDFL ARSGEAFLQI RRSCRKIFVL WCILAQNRIF QFDLNEIIPF
410 420 430 440
AQARLRMEMS EQRALELFEK EIRGAVGSLK TSVAHLINRV GMFLRR
Length:446
Mass (Da):52,007
Last modified:May 29, 2013 - v2
Checksum:i1750449946A5C2F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA. Translation: CAD25778.2.
RefSeqiNP_586174.1. NM_001042007.1.

Genome annotation databases

EnsemblFungiiCAD25778; CAD25778; CAD25778.
GeneIDi859823.
KEGGiecu:ECU10_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA. Translation: CAD25778.2.
RefSeqiNP_586174.1. NM_001042007.1.

3D structure databases

ProteinModelPortaliQ8SR56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284813.NP_586174.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAD25778; CAD25778; CAD25778.
GeneIDi859823.
KEGGiecu:ECU10_0590.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0590.

Phylogenomic databases

eggNOGiKOG0906. Eukaryota.
COG5032. LUCA.
HOGENOMiHOG000149280.
InParanoidiQ8SR56.
OrthoDBiEOG093100GK.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR015433. PI_Kinase.
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiView protein in Pfam
PF00454. PI3_PI4_kinase. 1 hit.
SMARTiView protein in SMART
SM00146. PI3Kc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50290. PI3_4_KINASE_3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVPS34_ENCCU
AccessioniPrimary (citable) accession number: Q8SR56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 29, 2013
Last modified: February 15, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.