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Q8SR56

- VPS34_ENCCU

UniProt

Q8SR56 - VPS34_ENCCU

Protein

Probable phosphatidylinositol 3-kinase VPS34 homolog

Gene

VPS34

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 2 (29 May 2013)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II By similarity.By similarity

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phosphatidylinositol-mediated signaling Source: InterPro
    2. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phosphatidylinositol 3-kinase VPS34 homolog (EC:2.7.1.137)
    Short name:
    PI3-kinase VPS34
    Short name:
    PI3K VPS34
    Short name:
    PtdIns-3-kinase VPS34
    Gene namesi
    Name:VPS34
    Ordered Locus Names:ECU10_0590
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome X

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU10_0590.

    Subcellular locationi

    GO - Cellular componenti

    1. endosome membrane Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Probable phosphatidylinositol 3-kinase VPS34 homologPRO_0000388438Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the autophagy-specific VPS34 PI3-kinase complex I composed; and of the VPS34 PI3-kinase complex II.By similarity

    Protein-protein interaction databases

    STRINGi6035.ECU10_0590.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini202 – 444243PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.Curated
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.
    HOGENOMiHOG000149280.
    OrthoDBiEOG7H79BZ.

    Family and domain databases

    Gene3Di1.10.1070.11. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR015433. PI_Kinase.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    [Graphical view]
    SMARTiSM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SR56-1 [UniParc]FASTAAdd to Basket

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    MEEWDGDVFT WNAGKEDIYT LIESILRLLK NGCKGMENMV VKYLGTGATD    50
    SLYMYFPWLR GRDLESRLSV EHQIDRFWKI RFELHEERTN SMDRYEDIVS 100
    SFLALDTKCG ILGKLEGQMA LVDEIRRIYS ITSQGSPRKK RLREYRLHGT 150
    LCLHPGAGSM RLYASLFSLD ATVKEIIFPE IEIFPSSTFP ILVPLRTDRG 200
    VSRIIYKKGD DLTRDLFVLE TIRYMSRLMG VDLVTYKVIP LSRKEGIVEV 250
    VDGIDFTRIR SRKDLEMYIE EDRDPRHQES FEKRKVFVST LCGYSVACYV 300
    MGIGDRNPGN MMVTRDGKFF HIDFSHVFGR DPKPISSRIT IARPIRDYLV 350
    NDELIYQDFL ARSGEAFLQI RRSCRKIFVL WCILAQNRIF QFDLNEIIPF 400
    AQARLRMEMS EQRALELFEK EIRGAVGSLK TSVAHLINRV GMFLRR 446
    Length:446
    Mass (Da):52,007
    Last modified:May 29, 2013 - v2
    Checksum:i1750449946A5C2F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590449 Genomic DNA. Translation: CAD25778.2.
    RefSeqiNP_586174.1. NM_001042007.1.

    Genome annotation databases

    GeneIDi859823.
    KEGGiecu:ECU10_0590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590449 Genomic DNA. Translation: CAD25778.2 .
    RefSeqi NP_586174.1. NM_001042007.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU10_0590.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859823.
    KEGGi ecu:ECU10_0590.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU10_0590.

    Phylogenomic databases

    eggNOGi COG5032.
    HOGENOMi HOG000149280.
    OrthoDBi EOG7H79BZ.

    Family and domain databases

    Gene3Di 1.10.1070.11. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR015433. PI_Kinase.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    [Graphical view ]
    SMARTi SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50290. PI3_4_KINASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
      Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
      BMC Genomics 10:607-607(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: GB-M1.

    Entry informationi

    Entry nameiVPS34_ENCCU
    AccessioniPrimary (citable) accession number: Q8SR56
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: May 29, 2013
    Last modified: October 1, 2014
    This is version 75 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3