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Q8SR56

- VPS34_ENCCU

UniProt

Q8SR56 - VPS34_ENCCU

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Protein

Probable phosphatidylinositol 3-kinase VPS34 homolog

Gene

VPS34

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 3-kinase VPS34 homolog (EC:2.7.1.137)
Short name:
PI3-kinase VPS34
Short name:
PI3K VPS34
Short name:
PtdIns-3-kinase VPS34
Gene namesi
Name:VPS34
Ordered Locus Names:ECU10_0590
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome X

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0590.

Subcellular locationi

GO - Cellular componenti

  1. endosome Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable phosphatidylinositol 3-kinase VPS34 homologPRO_0000388438Add
BLAST

Interactioni

Subunit structurei

Component of the autophagy-specific VPS34 PI3-kinase complex I composed; and of the VPS34 PI3-kinase complex II.By similarity

Protein-protein interaction databases

STRINGi6035.ECU10_0590.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 444243PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000149280.
InParanoidiQ8SR56.
OrthoDBiEOG7H79BZ.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SR56-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEWDGDVFT WNAGKEDIYT LIESILRLLK NGCKGMENMV VKYLGTGATD
60 70 80 90 100
SLYMYFPWLR GRDLESRLSV EHQIDRFWKI RFELHEERTN SMDRYEDIVS
110 120 130 140 150
SFLALDTKCG ILGKLEGQMA LVDEIRRIYS ITSQGSPRKK RLREYRLHGT
160 170 180 190 200
LCLHPGAGSM RLYASLFSLD ATVKEIIFPE IEIFPSSTFP ILVPLRTDRG
210 220 230 240 250
VSRIIYKKGD DLTRDLFVLE TIRYMSRLMG VDLVTYKVIP LSRKEGIVEV
260 270 280 290 300
VDGIDFTRIR SRKDLEMYIE EDRDPRHQES FEKRKVFVST LCGYSVACYV
310 320 330 340 350
MGIGDRNPGN MMVTRDGKFF HIDFSHVFGR DPKPISSRIT IARPIRDYLV
360 370 380 390 400
NDELIYQDFL ARSGEAFLQI RRSCRKIFVL WCILAQNRIF QFDLNEIIPF
410 420 430 440
AQARLRMEMS EQRALELFEK EIRGAVGSLK TSVAHLINRV GMFLRR
Length:446
Mass (Da):52,007
Last modified:May 29, 2013 - v2
Checksum:i1750449946A5C2F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590449 Genomic DNA. Translation: CAD25778.2.
RefSeqiNP_586174.1. NM_001042007.1.

Genome annotation databases

GeneIDi859823.
KEGGiecu:ECU10_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590449 Genomic DNA. Translation: CAD25778.2 .
RefSeqi NP_586174.1. NM_001042007.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU10_0590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859823.
KEGGi ecu:ECU10_0590.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU10_0590.

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000149280.
InParanoidi Q8SR56.
OrthoDBi EOG7H79BZ.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR015433. PI_Kinase.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
    Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
    BMC Genomics 10:607-607(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GB-M1.

Entry informationi

Entry nameiVPS34_ENCCU
AccessioniPrimary (citable) accession number: Q8SR56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 29, 2013
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3