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Q8SR56

- VPS34_ENCCU

UniProt

Q8SR56 - VPS34_ENCCU

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Protein
Probable phosphatidylinositol 3-kinase VPS34 homolog
Gene
VPS34, ECU10_0590
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II By similarity.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidylinositol 3-kinase VPS34 homolog (EC:2.7.1.137)
Short name:
PI3-kinase VPS34
Short name:
PI3K VPS34
Short name:
PtdIns-3-kinase VPS34
Gene namesi
Name:VPS34
Ordered Locus Names:ECU10_0590
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome X

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0590.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Probable phosphatidylinositol 3-kinase VPS34 homolog
PRO_0000388438Add
BLAST

Interactioni

Subunit structurei

Component of the autophagy-specific VPS34 PI3-kinase complex I composed; and of the VPS34 PI3-kinase complex II By similarity.

Protein-protein interaction databases

STRINGi6035.ECU10_0590.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 444243PI3K/PI4K
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 PI3K/PI4K domain.

Phylogenomic databases

eggNOGiCOG5032.
HOGENOMiHOG000149280.
OrthoDBiEOG7H79BZ.

Family and domain databases

Gene3Di1.10.1070.11. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR015433. PI_Kinase.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
SMARTiSM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SR56-1 [UniParc]FASTAAdd to Basket

« Hide

MEEWDGDVFT WNAGKEDIYT LIESILRLLK NGCKGMENMV VKYLGTGATD    50
SLYMYFPWLR GRDLESRLSV EHQIDRFWKI RFELHEERTN SMDRYEDIVS 100
SFLALDTKCG ILGKLEGQMA LVDEIRRIYS ITSQGSPRKK RLREYRLHGT 150
LCLHPGAGSM RLYASLFSLD ATVKEIIFPE IEIFPSSTFP ILVPLRTDRG 200
VSRIIYKKGD DLTRDLFVLE TIRYMSRLMG VDLVTYKVIP LSRKEGIVEV 250
VDGIDFTRIR SRKDLEMYIE EDRDPRHQES FEKRKVFVST LCGYSVACYV 300
MGIGDRNPGN MMVTRDGKFF HIDFSHVFGR DPKPISSRIT IARPIRDYLV 350
NDELIYQDFL ARSGEAFLQI RRSCRKIFVL WCILAQNRIF QFDLNEIIPF 400
AQARLRMEMS EQRALELFEK EIRGAVGSLK TSVAHLINRV GMFLRR 446
Length:446
Mass (Da):52,007
Last modified:May 29, 2013 - v2
Checksum:i1750449946A5C2F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590449 Genomic DNA. Translation: CAD25778.2.
RefSeqiNP_586174.1. NM_001042007.1.

Genome annotation databases

GeneIDi859823.
KEGGiecu:ECU10_0590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590449 Genomic DNA. Translation: CAD25778.2 .
RefSeqi NP_586174.1. NM_001042007.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU10_0590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 859823.
KEGGi ecu:ECU10_0590.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU10_0590.

Phylogenomic databases

eggNOGi COG5032.
HOGENOMi HOG000149280.
OrthoDBi EOG7H79BZ.

Family and domain databases

Gene3Di 1.10.1070.11. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR015433. PI_Kinase.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
[Graphical view ]
SMARTi SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50290. PI3_4_KINASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
    Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
    BMC Genomics 10:607-607(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GB-M1.

Entry informationi

Entry nameiVPS34_ENCCU
AccessioniPrimary (citable) accession number: Q8SR56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: May 29, 2013
Last modified: July 9, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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