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Q8SR40

- GPDH_ENCCU

UniProt

Q8SR40 - GPDH_ENCCU

Protein

Probable glycerol-3-phosphate dehydrogenase

Gene

ECU10_0870

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi57 – 8529FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycerol-3-phosphate dehydrogenase (EC:1.1.5.3)
    Short name:
    GPDH
    Gene namesi
    Ordered Locus Names:ECU10_0870
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome X

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU10_0870.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 614614Probable glycerol-3-phosphate dehydrogenasePRO_0000383045Add
    BLAST

    Proteomic databases

    PRIDEiQ8SR40.

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU10_0870.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SR40.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0578.
    HOGENOMiHOG000004813.
    KOiK00111.
    OMAiASGAFCD.
    OrthoDBiEOG7NSBB6.

    Family and domain databases

    InterProiIPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SR40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLVALVVLFL SVFMAMKFLY KRIFVASRLK MIEKPSEDWE PASREAMIER    50
    LRSEVFDLVV VGGGSTGAGC ALDGATRGLK VALVDAGDFG SGTSSKSTKL 100
    VHGGVRYLAK AVSNLDWSQY KLVWQALGER TTMFEISPYL TNSIKIMVPI 150
    YSKILIPYYY VGLKLYDWIS GFKSLGKSYF IDRKEAVDAF PHINKKNLCG 200
    AMVYFDGQQD DARNNVMIVM TAVCHGAVAA NHVSARSLMI EGGKIVGVRC 250
    RDEITGSEIE IRGTGVINST GNLADDLRRM DDADAREIIV QSSGTHIVIP 300
    KEYAPKEMGF LDPLTSDNRI AFFMPWMGKT IVGSTDIKTK TELSPSPTEE 350
    DLEFLIHEVQ AYTSMHPKLT RDEVSAVWTG IRPLVKDPDV SDTGSIVRKH 400
    FVRIEKNGLL TVTGGKWTIY RKMAEDAIDL AISAFSLKPS GPCVTKYVRI 450
    LGGDGYTKNT WASIQKELGV PKNVAERLAR SYGTRALRLS SYIKKNRKKV 500
    LSVKYSYLIE EVEYCIDNEM AVKVCDVLCN RLMIGLMDVK EAYQCIDKVL 550
    GVFKKKHGWD ADRCNREEAD AIRMLDKYGL QILRGCGQDA SSLQMECPEE 600
    KRHRGERRLP PQEK 614
    Length:614
    Mass (Da):68,640
    Last modified:June 1, 2002 - v1
    Checksum:i20942D4D6F7AC40E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590449 Genomic DNA. Translation: CAD25806.1.
    RefSeqiNP_586202.1. NM_001042035.1.

    Genome annotation databases

    GeneIDi859851.
    KEGGiecu:ECU10_0870.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590449 Genomic DNA. Translation: CAD25806.1 .
    RefSeqi NP_586202.1. NM_001042035.1.

    3D structure databases

    ProteinModelPortali Q8SR40.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU10_0870.

    Proteomic databases

    PRIDEi Q8SR40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859851.
    KEGGi ecu:ECU10_0870.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU10_0870.

    Phylogenomic databases

    eggNOGi COG0578.
    HOGENOMi HOG000004813.
    KOi K00111.
    OMAi ASGAFCD.
    OrthoDBi EOG7NSBB6.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .

    Family and domain databases

    InterProi IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.
    2. "Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi."
      Williams B.A.P., Cali A., Takvorian P.M., Keeling P.J.
      J. Eukaryot. Microbiol. 55:131-133(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGPDH_ENCCU
    AccessioniPrimary (citable) accession number: Q8SR40
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3