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Protein

Probable glycerol-3-phosphate dehydrogenase

Gene

ECU10_0870

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi57 – 8529FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase (EC:1.1.5.3)
Short name:
GPDH
Gene namesi
Ordered Locus Names:ECU10_0870
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819 Componenti: Chromosome X

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0870.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 614614Probable glycerol-3-phosphate dehydrogenasePRO_0000383045Add
BLAST

Proteomic databases

PRIDEiQ8SR40.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU10_0870.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004813.
InParanoidiQ8SR40.
KOiK00111.
OMAiAMRNELT.
OrthoDBiEOG7NSBB6.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SR40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVALVVLFL SVFMAMKFLY KRIFVASRLK MIEKPSEDWE PASREAMIER
60 70 80 90 100
LRSEVFDLVV VGGGSTGAGC ALDGATRGLK VALVDAGDFG SGTSSKSTKL
110 120 130 140 150
VHGGVRYLAK AVSNLDWSQY KLVWQALGER TTMFEISPYL TNSIKIMVPI
160 170 180 190 200
YSKILIPYYY VGLKLYDWIS GFKSLGKSYF IDRKEAVDAF PHINKKNLCG
210 220 230 240 250
AMVYFDGQQD DARNNVMIVM TAVCHGAVAA NHVSARSLMI EGGKIVGVRC
260 270 280 290 300
RDEITGSEIE IRGTGVINST GNLADDLRRM DDADAREIIV QSSGTHIVIP
310 320 330 340 350
KEYAPKEMGF LDPLTSDNRI AFFMPWMGKT IVGSTDIKTK TELSPSPTEE
360 370 380 390 400
DLEFLIHEVQ AYTSMHPKLT RDEVSAVWTG IRPLVKDPDV SDTGSIVRKH
410 420 430 440 450
FVRIEKNGLL TVTGGKWTIY RKMAEDAIDL AISAFSLKPS GPCVTKYVRI
460 470 480 490 500
LGGDGYTKNT WASIQKELGV PKNVAERLAR SYGTRALRLS SYIKKNRKKV
510 520 530 540 550
LSVKYSYLIE EVEYCIDNEM AVKVCDVLCN RLMIGLMDVK EAYQCIDKVL
560 570 580 590 600
GVFKKKHGWD ADRCNREEAD AIRMLDKYGL QILRGCGQDA SSLQMECPEE
610
KRHRGERRLP PQEK
Length:614
Mass (Da):68,640
Last modified:June 1, 2002 - v1
Checksum:i20942D4D6F7AC40E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA. Translation: CAD25806.1.
RefSeqiNP_586202.1. NM_001042035.1.

Genome annotation databases

GeneIDi859851.
KEGGiecu:ECU10_0870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA. Translation: CAD25806.1.
RefSeqiNP_586202.1. NM_001042035.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6035.ECU10_0870.

Proteomic databases

PRIDEiQ8SR40.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi859851.
KEGGiecu:ECU10_0870.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0870.

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004813.
InParanoidiQ8SR40.
KOiK00111.
OMAiAMRNELT.
OrthoDBiEOG7NSBB6.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi."
    Williams B.A.P., Cali A., Takvorian P.M., Keeling P.J.
    J. Eukaryot. Microbiol. 55:131-133(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGPDH_ENCCU
AccessioniPrimary (citable) accession number: Q8SR40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.