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Protein

Probable glycerol-3-phosphate dehydrogenase

Gene

ECU10_0870

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FADBy similarity

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable glycerol-3-phosphate dehydrogenase (ECU10_0870)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi57 – 85FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycerol-3-phosphate dehydrogenase (EC:1.1.5.3)
Short name:
GPDH
Gene namesi
Ordered Locus Names:ECU10_0870
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome X

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_0870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003830451 – 614Probable glycerol-3-phosphate dehydrogenaseAdd BLAST614

Proteomic databases

PRIDEiQ8SR40

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_586202.1

Structurei

3D structure databases

ProteinModelPortaliQ8SR40
SMRiQ8SR40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0042 Eukaryota
COG0578 LUCA
HOGENOMiHOG000004813
InParanoidiQ8SR40
KOiK00111
OMAiVPYYWVG
OrthoDBiEOG092C1H88

Family and domain databases

Gene3Di1.10.8.870, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR031656 DAO_C
IPR038299 DAO_C_sf
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR000447 G3P_DH_FAD-dep
PANTHERiPTHR11985 PTHR11985, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16901 DAO_C, 1 hit
PRINTSiPR01001 FADG3PDH
SUPFAMiSSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS00977 FAD_G3PDH_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SR40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVALVVLFL SVFMAMKFLY KRIFVASRLK MIEKPSEDWE PASREAMIER
60 70 80 90 100
LRSEVFDLVV VGGGSTGAGC ALDGATRGLK VALVDAGDFG SGTSSKSTKL
110 120 130 140 150
VHGGVRYLAK AVSNLDWSQY KLVWQALGER TTMFEISPYL TNSIKIMVPI
160 170 180 190 200
YSKILIPYYY VGLKLYDWIS GFKSLGKSYF IDRKEAVDAF PHINKKNLCG
210 220 230 240 250
AMVYFDGQQD DARNNVMIVM TAVCHGAVAA NHVSARSLMI EGGKIVGVRC
260 270 280 290 300
RDEITGSEIE IRGTGVINST GNLADDLRRM DDADAREIIV QSSGTHIVIP
310 320 330 340 350
KEYAPKEMGF LDPLTSDNRI AFFMPWMGKT IVGSTDIKTK TELSPSPTEE
360 370 380 390 400
DLEFLIHEVQ AYTSMHPKLT RDEVSAVWTG IRPLVKDPDV SDTGSIVRKH
410 420 430 440 450
FVRIEKNGLL TVTGGKWTIY RKMAEDAIDL AISAFSLKPS GPCVTKYVRI
460 470 480 490 500
LGGDGYTKNT WASIQKELGV PKNVAERLAR SYGTRALRLS SYIKKNRKKV
510 520 530 540 550
LSVKYSYLIE EVEYCIDNEM AVKVCDVLCN RLMIGLMDVK EAYQCIDKVL
560 570 580 590 600
GVFKKKHGWD ADRCNREEAD AIRMLDKYGL QILRGCGQDA SSLQMECPEE
610
KRHRGERRLP PQEK
Length:614
Mass (Da):68,640
Last modified:June 1, 2002 - v1
Checksum:i20942D4D6F7AC40E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA Translation: CAD25806.1
RefSeqiNP_586202.1, NM_001042035.1

Genome annotation databases

EnsemblFungiiCAD25806; CAD25806; CAD25806
GeneIDi859851
KEGGiecu:ECU10_0870

Similar proteinsi

Entry informationi

Entry nameiGPDH_ENCCU
AccessioniPrimary (citable) accession number: Q8SR40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health