Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8SR40 (GPDH_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycerol-3-phosphate dehydrogenase

Short name=GPDH
EC=1.1.5.3
Gene names
Ordered Locus Names:ECU10_0870
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length614 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactor

FAD By similarity.

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.

Subcellular location

Cytoplasm Ref.2.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 614614Probable glycerol-3-phosphate dehydrogenase
PRO_0000383045

Regions

Nucleotide binding57 – 8529FAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q8SR40 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 20942D4D6F7AC40E

FASTA61468,640
        10         20         30         40         50         60 
MLVALVVLFL SVFMAMKFLY KRIFVASRLK MIEKPSEDWE PASREAMIER LRSEVFDLVV 

        70         80         90        100        110        120 
VGGGSTGAGC ALDGATRGLK VALVDAGDFG SGTSSKSTKL VHGGVRYLAK AVSNLDWSQY 

       130        140        150        160        170        180 
KLVWQALGER TTMFEISPYL TNSIKIMVPI YSKILIPYYY VGLKLYDWIS GFKSLGKSYF 

       190        200        210        220        230        240 
IDRKEAVDAF PHINKKNLCG AMVYFDGQQD DARNNVMIVM TAVCHGAVAA NHVSARSLMI 

       250        260        270        280        290        300 
EGGKIVGVRC RDEITGSEIE IRGTGVINST GNLADDLRRM DDADAREIIV QSSGTHIVIP 

       310        320        330        340        350        360 
KEYAPKEMGF LDPLTSDNRI AFFMPWMGKT IVGSTDIKTK TELSPSPTEE DLEFLIHEVQ 

       370        380        390        400        410        420 
AYTSMHPKLT RDEVSAVWTG IRPLVKDPDV SDTGSIVRKH FVRIEKNGLL TVTGGKWTIY 

       430        440        450        460        470        480 
RKMAEDAIDL AISAFSLKPS GPCVTKYVRI LGGDGYTKNT WASIQKELGV PKNVAERLAR 

       490        500        510        520        530        540 
SYGTRALRLS SYIKKNRKKV LSVKYSYLIE EVEYCIDNEM AVKVCDVLCN RLMIGLMDVK 

       550        560        570        580        590        600 
EAYQCIDKVL GVFKKKHGWD ADRCNREEAD AIRMLDKYGL QILRGCGQDA SSLQMECPEE 

       610 
KRHRGERRLP PQEK 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.
[2]"Distinct localization patterns of two putative mitochondrial proteins in the microsporidian Encephalitozoon cuniculi."
Williams B.A.P., Cali A., Takvorian P.M., Keeling P.J.
J. Eukaryot. Microbiol. 55:131-133(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590449 Genomic DNA. Translation: CAD25806.1.
RefSeqNP_586202.1. NM_001042035.1.

3D structure databases

ProteinModelPortalQ8SR40.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU10_0870.

Proteomic databases

PRIDEQ8SR40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859851.
KEGGecu:ECU10_0870.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU10_0870.

Phylogenomic databases

eggNOGCOG0578.
HOGENOMHOG000004813.
KOK00111.
OMAANRFGSN.
OrthoDBEOG7NSBB6.

Enzyme and pathway databases

UniPathwayUPA00618; UER00673.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamPF01266. DAO. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
PROSITEPS00977. FAD_G3PDH_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPDH_ENCCU
AccessionPrimary (citable) accession number: Q8SR40
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: November 13, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways