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Protein

Probable proteasome subunit beta type-1

Gene

PRE3

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei11NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Protein family/group databases

MEROPSiT01.010

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit beta type-1 (EC:3.4.25.1)
Alternative name(s):
26S proteasome beta-type subunit PRE3
Multicatalytic endopeptidase complex subunit PRE3
Gene namesi
Name:PRE3
Ordered Locus Names:ECU10_1450
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_1450

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003914081 – 10Removed in mature formBy similarity10
ChainiPRO_000038276011 – 203Probable proteasome subunit beta type-1Add BLAST193

Proteomic databases

PRIDEiQ8SR11

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi284813.NP_586260.1

Structurei

3D structure databases

ProteinModelPortaliQ8SR11
SMRiQ8SR11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0174 Eukaryota
ENOG410XS23 LUCA
HOGENOMiHOG000091079
InParanoidiQ8SR11
KOiK02738
OMAiHDRIYCC
OrthoDBiEOG092C4SID

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR000243 Pept_T1A_subB
IPR037559 Proteasome_beta_Pre3
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF4 PTHR11599:SF4, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8SR11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSNEKEMTG TTIIAIKYDD GVLIGADSRT SMGAYVSSRV TDKLTQITDK
60 70 80 90 100
IFVCRSGSSA DTQMISSYLR MYLSMYSQLE DSIPQVQRAA ALASKIIYEN
110 120 130 140 150
PSLLAGLIVA GYDDKPRVFN ISLGGSLTER DWAIGGSGSA FIYGYCDVNW
160 170 180 190 200
RSGMSLEEGI RFVRNAVSCA INRDNASGGC IRMSAISRTG VQRYFYPGDK

VLQ
Length:203
Mass (Da):22,189
Last modified:June 1, 2002 - v1
Checksum:iDC82D2EAD817DA3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA Translation: CAD25864.1
RefSeqiNP_586260.1, NM_001042093.1

Genome annotation databases

EnsemblFungiiCAD25864; CAD25864; CAD25864
GeneIDi859910
KEGGiecu:ECU10_1450

Similar proteinsi

Entry informationi

Entry nameiPSB1_ENCCU
AccessioniPrimary (citable) accession number: Q8SR11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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