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Protein

Probable glutamine--tRNA ligase

Gene

ECU10_1460

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei237L-glutamineBy similarity1
Binding sitei386L-glutamineBy similarity1
Binding sitei405ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi205 – 207ATPBy similarity3
Nucleotide bindingi211 – 217ATPBy similarity7
Nucleotide bindingi434 – 435ATPBy similarity2
Nucleotide bindingi442 – 444ATPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--tRNA ligase (EC:6.1.1.18By similarity)
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name:
GlnRS
Gene namesi
Ordered Locus Names:ECU10_1460
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome X

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU10_1460.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003883811 – 697Probable glutamine--tRNA ligaseAdd BLAST697

Interactioni

Protein-protein interaction databases

STRINGi284813.NP_586261.1.

Structurei

3D structure databases

ProteinModelPortaliQ8SR10.
SMRiQ8SR10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 214"HIGH" regionBy similarityAdd BLAST11
Motifi441 – 445"KMSKS" regionBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1148. Eukaryota.
COG0008. LUCA.
HOGENOMiHOG000259233.
InParanoidiQ8SR10.
KOiK01886.
OMAiVTHSICT.
OrthoDBiEOG092C0PFH.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00440. glnS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8SR10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADLEKILER LGISPEKRCQ VIKKEQVVRN MEKIFLGRDL SNRLLYTLAC
60 70 80 90 100
IAPKNADLGL LADLVDARVI KHESMLKECL RYTEKKDVSM EEMTRFVKRN
110 120 130 140 150
EVSSEDVRKF VAKMRSDRVA KKDMVSKARK AMPCADFRVV VEEINKVPDD
160 170 180 190 200
VDGGDEKRPL EGGWLEEGEI KKLPKPSEIP QINEEIRQAH LRRTGGRVVT
210 220 230 240 250
RFPPEPNGIL HIGHAKAINL NFEYAKKFGG YTYLRYDDTN PKNEEAEYFD
260 270 280 290 300
SIYEDVRWLG FEPYKVTASS DYFDKMTEFG FQLIRKGKAY VCHLSQDEIC
310 320 330 340 350
ERRRQYVSDG TNDRSHLSQY RDRPVSENLR LFQEMVDGKW EEGKACLRFK
360 370 380 390 400
MDTDTKNPLM LDLVGIRILD VVHPRKNVKY TVYPTYEFAL CVSDSLEDVT
410 420 430 440 450
HSFCTREFYT RQESYNWLLV QLEIYKPIQW EFSRLNISNT VLSKRKLLPL
460 470 480 490 500
KKYGIELDDP RLFTIKGMRR RGFPPEAINQ FCRSLGFTFA ETTVDVKKLE
510 520 530 540 550
NFVRDNLNRT SRRIMCVKEP LKVTIMNSTP CSISIPDLPG SSVVRDVPFT
560 570 580 590 600
PVIYIEKSDF MEKGDKDFLR LTPEQPVGLY MLYPIRVVKV TPDGIVAERW
610 620 630 640 650
DGVPRKFIHW VSEDSVEVEM RMYSSLWTSF SPKDATYLEE MNKDSLKVFH
660 670 680 690
GLCDKRISDA RIEDRFQFQR IGYFCVDKDT TKENIVVNLT IPLKNIA
Length:697
Mass (Da):81,248
Last modified:June 1, 2002 - v1
Checksum:i045C9353A142AE04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590449 Genomic DNA. Translation: CAD25865.1.
RefSeqiNP_586261.1. NM_001042094.1.

Genome annotation databases

EnsemblFungiiCAD25865; CAD25865; CAD25865.
GeneIDi859911.
KEGGiecu:ECU10_1460.

Similar proteinsi

Entry informationi

Entry nameiSYQ_ENCCU
AccessioniPrimary (citable) accession number: Q8SR10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: August 30, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families