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Q8SR10

- SYQ_ENCCU

UniProt

Q8SR10 - SYQ_ENCCU

Protein

Probable glutamine--tRNA ligase

Gene

ECU10_1460

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei444 – 4441ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutaminyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutamine--tRNA ligase (EC:6.1.1.18)
    Alternative name(s):
    Glutaminyl-tRNA synthetase
    Short name:
    GlnRS
    Gene namesi
    Ordered Locus Names:ECU10_1460
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome X

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU10_1460.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 697697Probable glutamine--tRNA ligasePRO_0000388381Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU10_1460.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SR10.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi204 – 21411"HIGH" regionBy similarityAdd
    BLAST
    Motifi441 – 4455"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0008.
    HOGENOMiHOG000259233.
    KOiK01886.
    OMAiRMQKRAK.
    OrthoDBiEOG7MD4ZK.

    Family and domain databases

    Gene3Di1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR10119. PTHR10119. 1 hit.
    PfamiPF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view]
    PRINTSiPR00987. TRNASYNTHGLU.
    SUPFAMiSSF50715. SSF50715. 1 hit.
    TIGRFAMsiTIGR00440. glnS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SR10-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADLEKILER LGISPEKRCQ VIKKEQVVRN MEKIFLGRDL SNRLLYTLAC    50
    IAPKNADLGL LADLVDARVI KHESMLKECL RYTEKKDVSM EEMTRFVKRN 100
    EVSSEDVRKF VAKMRSDRVA KKDMVSKARK AMPCADFRVV VEEINKVPDD 150
    VDGGDEKRPL EGGWLEEGEI KKLPKPSEIP QINEEIRQAH LRRTGGRVVT 200
    RFPPEPNGIL HIGHAKAINL NFEYAKKFGG YTYLRYDDTN PKNEEAEYFD 250
    SIYEDVRWLG FEPYKVTASS DYFDKMTEFG FQLIRKGKAY VCHLSQDEIC 300
    ERRRQYVSDG TNDRSHLSQY RDRPVSENLR LFQEMVDGKW EEGKACLRFK 350
    MDTDTKNPLM LDLVGIRILD VVHPRKNVKY TVYPTYEFAL CVSDSLEDVT 400
    HSFCTREFYT RQESYNWLLV QLEIYKPIQW EFSRLNISNT VLSKRKLLPL 450
    KKYGIELDDP RLFTIKGMRR RGFPPEAINQ FCRSLGFTFA ETTVDVKKLE 500
    NFVRDNLNRT SRRIMCVKEP LKVTIMNSTP CSISIPDLPG SSVVRDVPFT 550
    PVIYIEKSDF MEKGDKDFLR LTPEQPVGLY MLYPIRVVKV TPDGIVAERW 600
    DGVPRKFIHW VSEDSVEVEM RMYSSLWTSF SPKDATYLEE MNKDSLKVFH 650
    GLCDKRISDA RIEDRFQFQR IGYFCVDKDT TKENIVVNLT IPLKNIA 697
    Length:697
    Mass (Da):81,248
    Last modified:June 1, 2002 - v1
    Checksum:i045C9353A142AE04
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590449 Genomic DNA. Translation: CAD25865.1.
    RefSeqiNP_586261.1. NM_001042094.1.

    Genome annotation databases

    GeneIDi859911.
    KEGGiecu:ECU10_1460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590449 Genomic DNA. Translation: CAD25865.1 .
    RefSeqi NP_586261.1. NM_001042094.1.

    3D structure databases

    ProteinModelPortali Q8SR10.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU10_1460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 859911.
    KEGGi ecu:ECU10_1460.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU10_1460.

    Phylogenomic databases

    eggNOGi COG0008.
    HOGENOMi HOG000259233.
    KOi K01886.
    OMAi RMQKRAK.
    OrthoDBi EOG7MD4ZK.

    Family and domain databases

    Gene3Di 1.10.1160.10. 1 hit.
    2.40.240.10. 2 hits.
    3.40.50.620. 2 hits.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR004514. Gln-tRNA-synth.
    IPR000924. Glu/Gln-tRNA-synth.
    IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
    IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
    IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
    IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
    IPR011035. Ribosomal_L25/Gln-tRNA_synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR10119. PTHR10119. 1 hit.
    Pfami PF00749. tRNA-synt_1c. 1 hit.
    PF03950. tRNA-synt_1c_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00987. TRNASYNTHGLU.
    SUPFAMi SSF50715. SSF50715. 1 hit.
    TIGRFAMsi TIGR00440. glnS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.

    Entry informationi

    Entry nameiSYQ_ENCCU
    AccessioniPrimary (citable) accession number: Q8SR10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3