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Q8SR10 (SYQ_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glutamine--tRNA ligase

EC=6.1.1.18
Alternative name(s):
Glutaminyl-tRNA synthetase
Short name=GlnRS
Gene names
Ordered Locus Names:ECU10_1460
OrganismEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]
Taxonomic identifier284813 [NCBI]
Taxonomic lineageEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon

Protein attributes

Sequence length697 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln).

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglutaminyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 697697Probable glutamine--tRNA ligase
PRO_0000388381

Regions

Motif204 – 21411"HIGH" region By similarity
Motif441 – 4455"KMSKS" region By similarity

Sites

Binding site4441ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8SR10 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: 045C9353A142AE04

FASTA69781,248
        10         20         30         40         50         60 
MADLEKILER LGISPEKRCQ VIKKEQVVRN MEKIFLGRDL SNRLLYTLAC IAPKNADLGL 

        70         80         90        100        110        120 
LADLVDARVI KHESMLKECL RYTEKKDVSM EEMTRFVKRN EVSSEDVRKF VAKMRSDRVA 

       130        140        150        160        170        180 
KKDMVSKARK AMPCADFRVV VEEINKVPDD VDGGDEKRPL EGGWLEEGEI KKLPKPSEIP 

       190        200        210        220        230        240 
QINEEIRQAH LRRTGGRVVT RFPPEPNGIL HIGHAKAINL NFEYAKKFGG YTYLRYDDTN 

       250        260        270        280        290        300 
PKNEEAEYFD SIYEDVRWLG FEPYKVTASS DYFDKMTEFG FQLIRKGKAY VCHLSQDEIC 

       310        320        330        340        350        360 
ERRRQYVSDG TNDRSHLSQY RDRPVSENLR LFQEMVDGKW EEGKACLRFK MDTDTKNPLM 

       370        380        390        400        410        420 
LDLVGIRILD VVHPRKNVKY TVYPTYEFAL CVSDSLEDVT HSFCTREFYT RQESYNWLLV 

       430        440        450        460        470        480 
QLEIYKPIQW EFSRLNISNT VLSKRKLLPL KKYGIELDDP RLFTIKGMRR RGFPPEAINQ 

       490        500        510        520        530        540 
FCRSLGFTFA ETTVDVKKLE NFVRDNLNRT SRRIMCVKEP LKVTIMNSTP CSISIPDLPG 

       550        560        570        580        590        600 
SSVVRDVPFT PVIYIEKSDF MEKGDKDFLR LTPEQPVGLY MLYPIRVVKV TPDGIVAERW 

       610        620        630        640        650        660 
DGVPRKFIHW VSEDSVEVEM RMYSSLWTSF SPKDATYLEE MNKDSLKVFH GLCDKRISDA 

       670        680        690 
RIEDRFQFQR IGYFCVDKDT TKENIVVNLT IPLKNIA 

« Hide

References

[1]"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi."
Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P.
Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GB-M1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL590449 Genomic DNA. Translation: CAD25865.1.
RefSeqNP_586261.1. NM_001042094.1.

3D structure databases

ProteinModelPortalQ8SR10.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6035.ECU10_1460.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID859911.
KEGGecu:ECU10_1460.

Organism-specific databases

EuPathDBMicrosporidiaDB:ECU10_1460.

Phylogenomic databases

eggNOGCOG0008.
HOGENOMHOG000259233.
KOK01886.
OMAWIGESPA.
OrthoDBEOG7MD4ZK.

Family and domain databases

Gene3D1.10.1160.10. 1 hit.
2.40.240.10. 2 hits.
3.40.50.620. 2 hits.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR004514. Gln-tRNA-synth.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR020056. Rbsml_L25/Gln-tRNA_synth_b-brl.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR10119. PTHR10119. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF50715. SSF50715. 1 hit.
TIGRFAMsTIGR00440. glnS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYQ_ENCCU
AccessionPrimary (citable) accession number: Q8SR10
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: November 13, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries