Q8SQW2 (CTK1_ENCCU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable CTD kinase subunit alpha homolog
Short name=CTDK-I subunit alpha
EC=2.7.11.23

Alternative name(s):
CTD kinase subunit 1

Gene names

Name:	CTK1
Ordered Locus Names:	ECU11_0960

Organism

Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) [Reference proteome]

Taxonomic identifier

284813 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Microsporidia › Apansporoblastina › Unikaryonidae › Encephalitozoon › Encephalitozoon cuniculi

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing By similarity. Ref.2
Catalytic activity	ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
Subunit structure	Component of the CTDK-I complex By similarity.
Subcellular location	Nucleus › nucleolus By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Transcription mRNA processing
Cellular component	Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II carboxy-terminal domain kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Probable CTD kinase subunit alpha homolog		PRO_0000385504
Regions
	Domain	22 – 297	276	Protein kinase
	Nucleotide binding	28 – 36	9	ATP By similarity
Sites
	Active site	139	1	Proton acceptor By similarity
	Binding site	49	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8SQW2 [UniParc]. Last modified June 1, 2002. Version 1. Checksum: 6E0D80A2ABFEED68	FASTA	329	37,291
	10 20 30 40 50 60 MEPAEEGEIL AHRRFTATKM EYEKIRIIGE GTFGQVILAR KGRARYALKK VSKEKEGLSV 70 80 90 100 110 120 TTIREVQVLR AMGHPSIVRL IEVVVEPGGD IYMVFPYFPY DLNRFIRSNK MTCSEIKHIF 130 140 150 160 170 180 YQIAQGVCYI HSKGIMHRDL KSANILLDQK LNASIADFGM ARYTTKTGAY TPGMVTLWYR 190 200 210 220 230 240 APEILLGSSS YTYAVDIWSL GCILTEMYLG HMIFQGSTEM LQLEMVIHAC GSINENSYPG 250 260 270 280 290 300 VQDLPGFRNF RLPQSPRRIE GIIRKHDASA VELVSKMLCL DPSKRITVEQ VVGSKYFEHE 310 320 ARRDASSAGL QGCSYREDRL SLSKRKNVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence and gene compaction of the eukaryote parasite Encephalitozoon cuniculi." Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F., Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P., Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J., Vivares C.P. Nature 414:450-453(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: GB-M1.
[2]	"The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe." Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J. BMC Genomics 8:309-309(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PREDICTION OF FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL590450 Genomic DNA. Translation: CAD26006.1.
RefSeq	NP_586402.1. NM_001042235.1.
3D structure databases
HSSP	HSSP built from PDB template 1XO2 based on UniProtKB Q00534.
ProteinModelPortal	Q8SQW2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	860055.
KEGG	ecu:ECU11_0960.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000233024.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CTK1_ENCCU

Accession

Primary (citable) accession number: Q8SQW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	June 1, 2002
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program