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Q8SQV6

- SYIC_ENCCU

UniProt

Q8SQV6 - SYIC_ENCCU

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Protein

Probable isoleucine--tRNA ligase, cytoplasmic

Gene

ECU11_1100

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei612 – 6121ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
Ordered Locus Names:ECU11_1100
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome XI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU11_1100.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10171017Probable isoleucine--tRNA ligase, cytoplasmicPRO_0000388378Add
BLAST

Proteomic databases

PRIDEiQ8SQV6.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU11_1100.

Structurei

3D structure databases

ProteinModelPortaliQ8SQV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" regionBy similarityAdd
BLAST
Motifi609 – 6135"KMSKS" regionBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0060.
HOGENOMiHOG000246403.
InParanoidiQ8SQV6.
KOiK01870.
OMAiNESINWI.
OrthoDBiEOG7FNCGS.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYRKNANFVE CEEEVLEYWR RNKSFERSCE RSRGREKFTF YDGPPFATGL
60 70 80 90 100
PHYGHLLSGT IKDTVTRFFY QQGYDVDRRF GWDCHGLPVE YEIDKKLGIS
110 120 130 140 150
SRAEVLEMGI GKYNAECRGI VMKYSSEWEA VVERLGRWVS FRDGYRTMDM
160 170 180 190 200
TFMESVWNIF KELFSRGLIY RGFRVMPFST ACSTPLSNFE SNQNYKDVSD
210 220 230 240 250
PSVLIAFPLL KPLGGYMLSL VAWTTTPWTL PSNCGLAVNP GFLYGVFEHK
260 270 280 290 300
EKFYLMHVDR IGEYFKDARI LQRVSGRELE GLEYEQPFDY FEEYRKKGFF
310 320 330 340 350
RVLASGFVTD TDGTGVVHCA PGFGECDYNA FVEKGLIREN DLVPCPVDEN
360 370 380 390 400
GRYTSEVRRY AGRYVKDCDK AILSDIRDKV LMNQRIVHKY PFCWRSDTPL
410 420 430 440 450
LYKLVPNWFV KVKDHVDSLL RNNEKINWVP PDIKYKRFHN WLENARDWSI
460 470 480 490 500
SRNRFWGTPI PLWVTEDYSD MICIGSVGEL EELSGRKIDD IHREFIDGIV
510 520 530 540 550
IHRNGREYRR VEEVLDCWFE SGSMPYAQDH WPFCKESGVD LGSLSVSGGE
560 570 580 590 600
ERNKKLVKEN FPAHFIGEGL DQTRGWFYTL HVISSLLFGQ PAFLNVVVNG
610 620 630 640 650
IVLAEDGRKM SKRLRNYPDP SHIFNTYGAD SLRMYLISSP VVEAENLKFS
660 670 680 690 700
EGGVKEVLKT LIIPWYNSLG FYLENRDVEP DGRSLPMDGW ITASFDNFAW
710 720 730 740 750
SLTRKMRKYE LSSVLTLALR FIDDLSNWYI RMYRKEIRAG HHAVLGEILK
760 770 780 790 800
KFSIVMGPFT PFFSEYSYQS LNPGESVHFQ EYPVCKNGTH PFEMAKSIIA
810 820 830 840 850
AVRRLRETNS ISLKTPLKSA TLMSSSSLYE GIKDYIDAIK TECNVLELLY
860 870 880 890 900
KEEDRSMFDI TVKPNFLSLK KDKATMKKKM KVIQGLTGDQ AYSLLSSPLV
910 920 930 940 950
VDGLEILRDD VLIVKKIRCE GIAQEFGDFS IIIDNTLDEG MVKMKIAREF
960 970 980 990 1000
HSYIQKLRKS AGLRVGDDVV VDIQCPDLKG IVSKYFDISF GSLGALSGRG
1010
EYEFDGTLYP VSLYKKL
Length:1,017
Mass (Da):117,392
Last modified:June 1, 2002 - v1
Checksum:i21B076581AA563B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590450 Genomic DNA. Translation: CAD26020.1.
RefSeqiNP_586416.1. NM_001042249.1.

Genome annotation databases

GeneIDi860069.
KEGGiecu:ECU11_1100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590450 Genomic DNA. Translation: CAD26020.1 .
RefSeqi NP_586416.1. NM_001042249.1.

3D structure databases

ProteinModelPortali Q8SQV6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU11_1100.

Proteomic databases

PRIDEi Q8SQV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860069.
KEGGi ecu:ECU11_1100.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU11_1100.

Phylogenomic databases

eggNOGi COG0060.
HOGENOMi HOG000246403.
InParanoidi Q8SQV6.
KOi K01870.
OMAi NESINWI.
OrthoDBi EOG7FNCGS.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiSYIC_ENCCU
AccessioniPrimary (citable) accession number: Q8SQV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3