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Q8SQV6

- SYIC_ENCCU

UniProt

Q8SQV6 - SYIC_ENCCU

Protein

Probable isoleucine--tRNA ligase, cytoplasmic

Gene

ECU11_1100

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei612 – 6121ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    Gene namesi
    Ordered Locus Names:ECU11_1100
    OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
    Taxonomic identifieri284813 [NCBI]
    Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
    ProteomesiUP000000819: Chromosome XI

    Organism-specific databases

    EuPathDBiMicrosporidiaDB:ECU11_1100.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10171017Probable isoleucine--tRNA ligase, cytoplasmicPRO_0000388378Add
    BLAST

    Proteomic databases

    PRIDEiQ8SQV6.

    Interactioni

    Protein-protein interaction databases

    STRINGi6035.ECU11_1100.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8SQV6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 5511"HIGH" regionBy similarityAdd
    BLAST
    Motifi609 – 6135"KMSKS" regionBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0060.
    HOGENOMiHOG000246403.
    KOiK01870.
    OMAiNESINWI.
    OrthoDBiEOG7FNCGS.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00392. ileS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8SQV6-1 [UniParc]FASTAAdd to Basket

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    MYRKNANFVE CEEEVLEYWR RNKSFERSCE RSRGREKFTF YDGPPFATGL     50
    PHYGHLLSGT IKDTVTRFFY QQGYDVDRRF GWDCHGLPVE YEIDKKLGIS 100
    SRAEVLEMGI GKYNAECRGI VMKYSSEWEA VVERLGRWVS FRDGYRTMDM 150
    TFMESVWNIF KELFSRGLIY RGFRVMPFST ACSTPLSNFE SNQNYKDVSD 200
    PSVLIAFPLL KPLGGYMLSL VAWTTTPWTL PSNCGLAVNP GFLYGVFEHK 250
    EKFYLMHVDR IGEYFKDARI LQRVSGRELE GLEYEQPFDY FEEYRKKGFF 300
    RVLASGFVTD TDGTGVVHCA PGFGECDYNA FVEKGLIREN DLVPCPVDEN 350
    GRYTSEVRRY AGRYVKDCDK AILSDIRDKV LMNQRIVHKY PFCWRSDTPL 400
    LYKLVPNWFV KVKDHVDSLL RNNEKINWVP PDIKYKRFHN WLENARDWSI 450
    SRNRFWGTPI PLWVTEDYSD MICIGSVGEL EELSGRKIDD IHREFIDGIV 500
    IHRNGREYRR VEEVLDCWFE SGSMPYAQDH WPFCKESGVD LGSLSVSGGE 550
    ERNKKLVKEN FPAHFIGEGL DQTRGWFYTL HVISSLLFGQ PAFLNVVVNG 600
    IVLAEDGRKM SKRLRNYPDP SHIFNTYGAD SLRMYLISSP VVEAENLKFS 650
    EGGVKEVLKT LIIPWYNSLG FYLENRDVEP DGRSLPMDGW ITASFDNFAW 700
    SLTRKMRKYE LSSVLTLALR FIDDLSNWYI RMYRKEIRAG HHAVLGEILK 750
    KFSIVMGPFT PFFSEYSYQS LNPGESVHFQ EYPVCKNGTH PFEMAKSIIA 800
    AVRRLRETNS ISLKTPLKSA TLMSSSSLYE GIKDYIDAIK TECNVLELLY 850
    KEEDRSMFDI TVKPNFLSLK KDKATMKKKM KVIQGLTGDQ AYSLLSSPLV 900
    VDGLEILRDD VLIVKKIRCE GIAQEFGDFS IIIDNTLDEG MVKMKIAREF 950
    HSYIQKLRKS AGLRVGDDVV VDIQCPDLKG IVSKYFDISF GSLGALSGRG 1000
    EYEFDGTLYP VSLYKKL 1017
    Length:1,017
    Mass (Da):117,392
    Last modified:June 1, 2002 - v1
    Checksum:i21B076581AA563B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590450 Genomic DNA. Translation: CAD26020.1.
    RefSeqiNP_586416.1. NM_001042249.1.

    Genome annotation databases

    GeneIDi860069.
    KEGGiecu:ECU11_1100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL590450 Genomic DNA. Translation: CAD26020.1 .
    RefSeqi NP_586416.1. NM_001042249.1.

    3D structure databases

    ProteinModelPortali Q8SQV6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6035.ECU11_1100.

    Proteomic databases

    PRIDEi Q8SQV6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 860069.
    KEGGi ecu:ECU11_1100.

    Organism-specific databases

    EuPathDBi MicrosporidiaDB:ECU11_1100.

    Phylogenomic databases

    eggNOGi COG0060.
    HOGENOMi HOG000246403.
    KOi K01870.
    OMAi NESINWI.
    OrthoDBi EOG7FNCGS.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00392. ileS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: GB-M1.

    Entry informationi

    Entry nameiSYIC_ENCCU
    AccessioniPrimary (citable) accession number: Q8SQV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3