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Q8SQV6

- SYIC_ENCCU

UniProt

Q8SQV6 - SYIC_ENCCU

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Protein
Probable isoleucine--tRNA ligase, cytoplasmic
Gene
ECU11_1100
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei612 – 6121ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable isoleucine--tRNA ligase, cytoplasmic (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
Ordered Locus Names:ECU11_1100
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome XI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU11_1100.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10171017Probable isoleucine--tRNA ligase, cytoplasmic
PRO_0000388378Add
BLAST

Proteomic databases

PRIDEiQ8SQV6.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU11_1100.

Structurei

3D structure databases

ProteinModelPortaliQ8SQV6.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 5511"HIGH" region By similarity
Add
BLAST
Motifi609 – 6135"KMSKS" region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0060.
HOGENOMiHOG000246403.
KOiK01870.
OMAiNESINWI.
OrthoDBiEOG7FNCGS.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQV6-1 [UniParc]FASTAAdd to Basket

« Hide

MYRKNANFVE CEEEVLEYWR RNKSFERSCE RSRGREKFTF YDGPPFATGL     50
PHYGHLLSGT IKDTVTRFFY QQGYDVDRRF GWDCHGLPVE YEIDKKLGIS 100
SRAEVLEMGI GKYNAECRGI VMKYSSEWEA VVERLGRWVS FRDGYRTMDM 150
TFMESVWNIF KELFSRGLIY RGFRVMPFST ACSTPLSNFE SNQNYKDVSD 200
PSVLIAFPLL KPLGGYMLSL VAWTTTPWTL PSNCGLAVNP GFLYGVFEHK 250
EKFYLMHVDR IGEYFKDARI LQRVSGRELE GLEYEQPFDY FEEYRKKGFF 300
RVLASGFVTD TDGTGVVHCA PGFGECDYNA FVEKGLIREN DLVPCPVDEN 350
GRYTSEVRRY AGRYVKDCDK AILSDIRDKV LMNQRIVHKY PFCWRSDTPL 400
LYKLVPNWFV KVKDHVDSLL RNNEKINWVP PDIKYKRFHN WLENARDWSI 450
SRNRFWGTPI PLWVTEDYSD MICIGSVGEL EELSGRKIDD IHREFIDGIV 500
IHRNGREYRR VEEVLDCWFE SGSMPYAQDH WPFCKESGVD LGSLSVSGGE 550
ERNKKLVKEN FPAHFIGEGL DQTRGWFYTL HVISSLLFGQ PAFLNVVVNG 600
IVLAEDGRKM SKRLRNYPDP SHIFNTYGAD SLRMYLISSP VVEAENLKFS 650
EGGVKEVLKT LIIPWYNSLG FYLENRDVEP DGRSLPMDGW ITASFDNFAW 700
SLTRKMRKYE LSSVLTLALR FIDDLSNWYI RMYRKEIRAG HHAVLGEILK 750
KFSIVMGPFT PFFSEYSYQS LNPGESVHFQ EYPVCKNGTH PFEMAKSIIA 800
AVRRLRETNS ISLKTPLKSA TLMSSSSLYE GIKDYIDAIK TECNVLELLY 850
KEEDRSMFDI TVKPNFLSLK KDKATMKKKM KVIQGLTGDQ AYSLLSSPLV 900
VDGLEILRDD VLIVKKIRCE GIAQEFGDFS IIIDNTLDEG MVKMKIAREF 950
HSYIQKLRKS AGLRVGDDVV VDIQCPDLKG IVSKYFDISF GSLGALSGRG 1000
EYEFDGTLYP VSLYKKL 1017
Length:1,017
Mass (Da):117,392
Last modified:June 1, 2002 - v1
Checksum:i21B076581AA563B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590450 Genomic DNA. Translation: CAD26020.1.
RefSeqiNP_586416.1. NM_001042249.1.

Genome annotation databases

GeneIDi860069.
KEGGiecu:ECU11_1100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590450 Genomic DNA. Translation: CAD26020.1 .
RefSeqi NP_586416.1. NM_001042249.1.

3D structure databases

ProteinModelPortali Q8SQV6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU11_1100.

Proteomic databases

PRIDEi Q8SQV6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860069.
KEGGi ecu:ECU11_1100.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU11_1100.

Phylogenomic databases

eggNOGi COG0060.
HOGENOMi HOG000246403.
KOi K01870.
OMAi NESINWI.
OrthoDBi EOG7FNCGS.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.

Entry informationi

Entry nameiSYIC_ENCCU
AccessioniPrimary (citable) accession number: Q8SQV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 1, 2002
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi