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Protein

Probable cell division protein kinase ECU11_1290

Gene

ECU11_1290

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a role in the control of the eukaryotic cell cycle.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATPPROSITE-ProRule annotation
Active sitei138 – 1381Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cell division protein kinase ECU11_1290 (EC:2.7.11.22)
Gene namesi
Ordered Locus Names:ECU11_1290
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU11_1290.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Probable cell division protein kinase ECU11_1290PRO_0000385506Add
BLAST

Proteomic databases

PRIDEiQ8SQU8.

Interactioni

Protein-protein interaction databases

STRINGi6035.ECU11_1290.

Structurei

3D structure databases

ProteinModelPortaliQ8SQU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 294282Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ8SQU8.
KOiK08818.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGGRCNSI ENYEKVCRIS SGSFGNVYRV RRKTDNRVFA LKRMNPSMCY
60 70 80 90 100
DTNGFSILYI REVMILKHIR HRNIMEIEEV VEGCEINDFF IVMECCDTDL
110 120 130 140 150
RSVIHSVGKI GMKAARFLTC QMLKGLKFLH GAGIVHRDLK PSNILLMRDG
160 170 180 190 200
GLRIADFGLA RAIESQMTNL VVTLWYRPIE ILLGSETYDE SIDMWSVGCV
210 220 230 240 250
VGEMLRGEPI LAGEGEMDQL DRIFRLLGYP TDADFEGLDL PHFKNIRRPS
260 270 280 290 300
TFEASFEGDF ECYGEEAASF VRNLLSFDPR KRCTASQGLC SGFVADAEEC
310
PGELVDIVGR CTGDI
Length:315
Mass (Da):35,550
Last modified:May 29, 2013 - v2
Checksum:i6328576685C3E217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590450 Genomic DNA. Translation: CAD26039.2.
RefSeqiNP_586435.1. NM_001042268.1.

Genome annotation databases

GeneIDi860089.
KEGGiecu:ECU11_1290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590450 Genomic DNA. Translation: CAD26039.2.
RefSeqiNP_586435.1. NM_001042268.1.

3D structure databases

ProteinModelPortaliQ8SQU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6035.ECU11_1290.

Proteomic databases

PRIDEiQ8SQU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi860089.
KEGGiecu:ECU11_1290.

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU11_1290.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ8SQU8.
KOiK08818.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation."
    Peyretaillade E., Goncalves O., Terrat S., Dugat-Bony E., Wincker P., Cornman R.S., Evans J.D., Delbac F., Peyret P.
    BMC Genomics 10:607-607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: GB-M1.
  3. "The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
    Miranda-Saavedra D., Stark M.J.R., Packer J.C., Vivares C.P., Doerig C., Barton G.J.
    BMC Genomics 8:309-309(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PREDICTION OF FUNCTION.

Entry informationi

Entry nameiYBC9_ENCCU
AccessioniPrimary (citable) accession number: Q8SQU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 29, 2013
Last modified: February 4, 2015
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.