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Protein

Probable proteasome subunit alpha type-7

Gene

PRE10

Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-7 (EC:3.4.25.1)
Alternative name(s):
26S proteasome alpha-type subunit PRE10
Multicatalytic endopeptidase complex subunit PRE10
Gene namesi
Name:PRE10
Ordered Locus Names:ECU09_0330
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiFungi incertae sedisMicrosporidiaUnikaryonidaeEncephalitozoon
Proteomesi
  • UP000000819 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU09_0330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003827541 – 242Probable proteasome subunit alpha type-7Add BLAST242

Proteomic databases

PRIDEiQ8SQP9

Expressioni

Developmental stagei

Expressed in late sporogonial stages.1 Publication

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi284813.XP_955585.1

Structurei

3D structure databases

ProteinModelPortaliQ8SQP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0184 Eukaryota
ENOG410XP01 LUCA
HOGENOMiHOG000149185
InParanoidiQ8SQP9
KOiK02727
OMAiNGQHCIN
OrthoDBiEOG092C47D8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR037555 Proteasome_alpha_3
IPR001353 Proteasome_sua/b
PANTHERiPTHR11599:SF10 PTHR11599:SF10, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8SQP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLDFCTIY TTTGQIDQLS YAQKAADSGD TCIGMKSKHG VVLLAEKPRV
60 70 80 90 100
SPLYILESDE KIRKIGNTIG VVCTGMSSDT FYVGCAIKDY VFHHKENFNE
110 120 130 140 150
DPTPGMMKVY LNDIFHYFTR GINLRVLGAN TLTSVYKDGS FSLLHTDCSG
160 170 180 190 200
KTLSYKAACI GKGTRRIKTE LEKLDIDTMT IEEMVDVGVK VLYMAHDPSK
210 220 230 240
DKEFDIEIGI ASMETGGDLR KLENHEIRPL VGKYKHISVD ED
Length:242
Mass (Da):26,999
Last modified:June 1, 2002 - v1
Checksum:iE61FDC0E5AC3050E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590451 Genomic DNA Translation: CAD27004.1
RefSeqiXP_955585.1, XM_950492.1

Genome annotation databases

EnsemblFungiiCAD27004; CAD27004; CAD27004
GeneIDi860369
KEGGiecu:ECU09_0330

Similar proteinsi

Entry informationi

Entry nameiPSA7_ENCCU
AccessioniPrimary (citable) accession number: Q8SQP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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