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Q8SQP9

- PSA7_ENCCU

UniProt

Q8SQP9 - PSA7_ENCCU

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Protein

Probable proteasome subunit alpha type-7

Gene
PRE10, ECU09_0330
Organism
Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity By similarity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable proteasome subunit alpha type-7 (EC:3.4.25.1)
Alternative name(s):
26S proteasome alpha-type subunit PRE10
Multicatalytic endopeptidase complex subunit PRE10
Gene namesi
Name:PRE10
Ordered Locus Names:ECU09_0330
OrganismiEncephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)
Taxonomic identifieri284813 [NCBI]
Taxonomic lineageiEukaryotaFungiMicrosporidiaUnikaryonidaeEncephalitozoon
ProteomesiUP000000819: Chromosome IX

Organism-specific databases

EuPathDBiMicrosporidiaDB:ECU09_0330.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. proteasome core complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Probable proteasome subunit alpha type-7PRO_0000382754Add
BLAST

Expressioni

Developmental stagei

Expressed in late sporogonial stages.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel By similarity.

Protein-protein interaction databases

STRINGi6035.ECU09_0330.

Structurei

3D structure databases

ProteinModelPortaliQ8SQP9.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000149185.
KOiK02727.
OMAiVYLNDIF.
OrthoDBiEOG7SBP0C.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8SQP9-1 [UniParc]FASTAAdd to Basket

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MSNLDFCTIY TTTGQIDQLS YAQKAADSGD TCIGMKSKHG VVLLAEKPRV    50
SPLYILESDE KIRKIGNTIG VVCTGMSSDT FYVGCAIKDY VFHHKENFNE 100
DPTPGMMKVY LNDIFHYFTR GINLRVLGAN TLTSVYKDGS FSLLHTDCSG 150
KTLSYKAACI GKGTRRIKTE LEKLDIDTMT IEEMVDVGVK VLYMAHDPSK 200
DKEFDIEIGI ASMETGGDLR KLENHEIRPL VGKYKHISVD ED 242
Length:242
Mass (Da):26,999
Last modified:June 1, 2002 - v1
Checksum:iE61FDC0E5AC3050E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590451 Genomic DNA. Translation: CAD27004.1.
RefSeqiXP_955585.1. XM_950492.1.

Genome annotation databases

GeneIDi860369.
KEGGiecu:ECU09_0330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL590451 Genomic DNA. Translation: CAD27004.1 .
RefSeqi XP_955585.1. XM_950492.1.

3D structure databases

ProteinModelPortali Q8SQP9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6035.ECU09_0330.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 860369.
KEGGi ecu:ECU09_0330.

Organism-specific databases

EuPathDBi MicrosporidiaDB:ECU09_0330.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000149185.
KOi K02727.
OMAi VYLNDIF.
OrthoDBi EOG7SBP0C.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: GB-M1.
  2. "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a reference map for proteins expressed in late sporogonial stages."
    Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.
    Proteomics 6:3625-3635(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPSA7_ENCCU
AccessioniPrimary (citable) accession number: Q8SQP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: June 1, 2002
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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